Intraneural stimulation elicits discrimination of textural features by artificial fingertip in intact and amputee humans
Restoration of touch after hand amputation is a desirable feature of ideal prostheses. Here, we show that texture discrimination can be artificially provided in human subjects by implementing a neuromorphic real-time mechano-neuro-transduction (MNT), which emulates to some extent the firing dynamics...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2016-03-01
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| Series: | eLife |
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| Online Access: | https://elifesciences.org/articles/09148 |
| _version_ | 1811227396852940800 |
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| author | Calogero Maria Oddo Stanisa Raspopovic Fiorenzo Artoni Alberto Mazzoni Giacomo Spigler Francesco Petrini Federica Giambattistelli Fabrizio Vecchio Francesca Miraglia Loredana Zollo Giovanni Di Pino Domenico Camboni Maria Chiara Carrozza Eugenio Guglielmelli Paolo Maria Rossini Ugo Faraguna Silvestro Micera |
| author_facet | Calogero Maria Oddo Stanisa Raspopovic Fiorenzo Artoni Alberto Mazzoni Giacomo Spigler Francesco Petrini Federica Giambattistelli Fabrizio Vecchio Francesca Miraglia Loredana Zollo Giovanni Di Pino Domenico Camboni Maria Chiara Carrozza Eugenio Guglielmelli Paolo Maria Rossini Ugo Faraguna Silvestro Micera |
| author_sort | Calogero Maria Oddo |
| collection | DOAJ |
| description | Restoration of touch after hand amputation is a desirable feature of ideal prostheses. Here, we show that texture discrimination can be artificially provided in human subjects by implementing a neuromorphic real-time mechano-neuro-transduction (MNT), which emulates to some extent the firing dynamics of SA1 cutaneous afferents. The MNT process was used to modulate the temporal pattern of electrical spikes delivered to the human median nerve via percutaneous microstimulation in four intact subjects and via implanted intrafascicular stimulation in one transradial amputee. Both approaches allowed the subjects to reliably discriminate spatial coarseness of surfaces as confirmed also by a hybrid neural model of the median nerve. Moreover, MNT-evoked EEG activity showed physiologically plausible responses that were superimposable in time and topography to the ones elicited by a natural mechanical tactile stimulation. These findings can open up novel opportunities for sensory restoration in the next generation of neuro-prosthetic hands. |
| first_indexed | 2024-04-12T09:41:51Z |
| format | Article |
| id | doaj.art-0fd6c4ec66814a4986cf775982e95e22 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-12T09:41:51Z |
| publishDate | 2016-03-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-0fd6c4ec66814a4986cf775982e95e222022-12-22T03:38:03ZengeLife Sciences Publications LtdeLife2050-084X2016-03-01510.7554/eLife.09148Intraneural stimulation elicits discrimination of textural features by artificial fingertip in intact and amputee humansCalogero Maria Oddo0https://orcid.org/0000-0002-1489-5701Stanisa Raspopovic1Fiorenzo Artoni2Alberto Mazzoni3Giacomo Spigler4Francesco Petrini5Federica Giambattistelli6Fabrizio Vecchio7Francesca Miraglia8Loredana Zollo9Giovanni Di Pino10Domenico Camboni11Maria Chiara Carrozza12Eugenio Guglielmelli13Paolo Maria Rossini14Ugo Faraguna15Silvestro Micera16https://orcid.org/0000-0003-4396-8217The BioRobotics Institute, Scuola Superiore Sant'Anna, Pisa, ItalyThe BioRobotics Institute, Scuola Superiore Sant'Anna, Pisa, Italy; Bertarelli Foundation Chair in Translational NeuroEngineering, Institute of Bioengineering, School of Engineering, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland; Center for Neuroprosthetics, École Polytechnique Fédérale de Lausanne, Lausanne, SwitzerlandThe BioRobotics Institute, Scuola Superiore Sant'Anna, Pisa, Italy; Bertarelli Foundation Chair in Translational NeuroEngineering, Institute of Bioengineering, School of Engineering, École Polytechnique Fédérale de Lausanne, Lausanne, SwitzerlandThe BioRobotics Institute, Scuola Superiore Sant'Anna, Pisa, ItalyThe BioRobotics Institute, Scuola Superiore Sant'Anna, Pisa, ItalyBertarelli Foundation Chair in Translational NeuroEngineering, Institute of Bioengineering, School of Engineering, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland; Center for Neuroprosthetics, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland; Laboratory of Biomedical Robotics & Biomicrosystems, Università Campus Bio-Medico di Roma, Roma, Italy; Brain Connectivity Laboratory, IRCCS San Raffaele Pisana, Roma, ItalyInstitute of Neurology, Università Campus Bio-Medico di Roma, Roma, ItalyBrain Connectivity Laboratory, IRCCS San Raffaele Pisana, Roma, ItalyBrain Connectivity Laboratory, IRCCS San Raffaele Pisana, Roma, ItalyLaboratory of Biomedical Robotics & Biomicrosystems, Università Campus Bio-Medico di Roma, Roma, ItalyLaboratory of Biomedical Robotics & Biomicrosystems, Università Campus Bio-Medico di Roma, Roma, Italy; Institute of Neurology, Università Campus Bio-Medico di Roma, Roma, ItalyThe BioRobotics Institute, Scuola Superiore Sant'Anna, Pisa, ItalyThe BioRobotics Institute, Scuola Superiore Sant'Anna, Pisa, ItalyLaboratory of Biomedical Robotics & Biomicrosystems, Università Campus Bio-Medico di Roma, Roma, ItalyBrain Connectivity Laboratory, IRCCS San Raffaele Pisana, Roma, Italy; Institute of Neurology, Catholic University of The Sacred Heart, Roma, ItalyAzienda Ospedaliero-Universitaria Pisana, Pisa, Italy; IRCCS Stella Maris Foundation, Pisa, Italy; Dipartimento di Ricerca Traslazionale e delle Nuove Tecnologie in Medicina e Chirurgia, Università di Pisa, Pisa, ItalyThe BioRobotics Institute, Scuola Superiore Sant'Anna, Pisa, Italy; Center for Neuroprosthetics, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland; Bertarelli Foundation Chair in Translational NeuroEngineering, Institute of Bioengineering, School of Engineering, École Polytechnique Fédérale de Lausanne, Lausanne, SwitzerlandRestoration of touch after hand amputation is a desirable feature of ideal prostheses. Here, we show that texture discrimination can be artificially provided in human subjects by implementing a neuromorphic real-time mechano-neuro-transduction (MNT), which emulates to some extent the firing dynamics of SA1 cutaneous afferents. The MNT process was used to modulate the temporal pattern of electrical spikes delivered to the human median nerve via percutaneous microstimulation in four intact subjects and via implanted intrafascicular stimulation in one transradial amputee. Both approaches allowed the subjects to reliably discriminate spatial coarseness of surfaces as confirmed also by a hybrid neural model of the median nerve. Moreover, MNT-evoked EEG activity showed physiologically plausible responses that were superimposable in time and topography to the ones elicited by a natural mechanical tactile stimulation. These findings can open up novel opportunities for sensory restoration in the next generation of neuro-prosthetic hands.https://elifesciences.org/articles/09148intraneural stimulationtouch restorationartificial touchhand neuroprostheticstactile codeneuromorphic stimuli |
| spellingShingle | Calogero Maria Oddo Stanisa Raspopovic Fiorenzo Artoni Alberto Mazzoni Giacomo Spigler Francesco Petrini Federica Giambattistelli Fabrizio Vecchio Francesca Miraglia Loredana Zollo Giovanni Di Pino Domenico Camboni Maria Chiara Carrozza Eugenio Guglielmelli Paolo Maria Rossini Ugo Faraguna Silvestro Micera Intraneural stimulation elicits discrimination of textural features by artificial fingertip in intact and amputee humans eLife intraneural stimulation touch restoration artificial touch hand neuroprosthetics tactile code neuromorphic stimuli |
| title | Intraneural stimulation elicits discrimination of textural features by artificial fingertip in intact and amputee humans |
| title_full | Intraneural stimulation elicits discrimination of textural features by artificial fingertip in intact and amputee humans |
| title_fullStr | Intraneural stimulation elicits discrimination of textural features by artificial fingertip in intact and amputee humans |
| title_full_unstemmed | Intraneural stimulation elicits discrimination of textural features by artificial fingertip in intact and amputee humans |
| title_short | Intraneural stimulation elicits discrimination of textural features by artificial fingertip in intact and amputee humans |
| title_sort | intraneural stimulation elicits discrimination of textural features by artificial fingertip in intact and amputee humans |
| topic | intraneural stimulation touch restoration artificial touch hand neuroprosthetics tactile code neuromorphic stimuli |
| url | https://elifesciences.org/articles/09148 |
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