SARS-Cov2 acute and post-active infection in the context of autoimmune and chronic inflammatory diseases
The clinical and immunological spectrum of acute and post-active COVID-19 syndrome overlaps with criteria used to characterize autoimmune diseases such as rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). Indeed, following SARS-Cov2 infection, the innate immune response is altered wi...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-01-01
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| Series: | Journal of Translational Autoimmunity |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589909022000156 |
| _version_ | 1797980785828954112 |
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| author | Regina Larionova K. Byvaltsev Оlga Kravtsova Elena Takha Sergei Petrov Gevorg Kazarian Anna Valeeva Eduard Shuralev Malik Mukminov Yves Renaudineau Marina Arleevskaya |
| author_facet | Regina Larionova K. Byvaltsev Оlga Kravtsova Elena Takha Sergei Petrov Gevorg Kazarian Anna Valeeva Eduard Shuralev Malik Mukminov Yves Renaudineau Marina Arleevskaya |
| author_sort | Regina Larionova |
| collection | DOAJ |
| description | The clinical and immunological spectrum of acute and post-active COVID-19 syndrome overlaps with criteria used to characterize autoimmune diseases such as rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). Indeed, following SARS-Cov2 infection, the innate immune response is altered with an initial delayed production of interferon type I (IFN–I), while the NF-kappa B and inflammasome pathways are activated. In lung and digestive tissues, an alternative and extrafollicular immune response against SARS-Cov2 takes place with, consequently, an altered humoral and memory T cell response leading to breakdown of tolerance with the emergence of autoantibodies. However, the risk of developing severe COVID-19 among SLE and RA patients did not exceed the general population except in those having pre-existing neutralizing autoantibodies against IFN-I. Treatment discontinuation rather than COVID-19 infection or vaccination increases the risk of developing flares. Last but not least, a limited number of case reports of individuals having developed SLE or RA following COVID-19 infection/vaccination have been reported. Altogether, the SARS-Cov2 pandemic represents an unique opportunity to investigate the dangerous interplay between the immune response against infectious agents and autoimmunity, and to better understand the triggering role of infection as a risk factor in autoimmune and chronic inflammatory disease development. |
| first_indexed | 2024-04-11T06:00:29Z |
| format | Article |
| id | doaj.art-0fd7fd7a2146472e9a5a2072d5e0bc9f |
| institution | Directory Open Access Journal |
| issn | 2589-9090 |
| language | English |
| last_indexed | 2024-04-11T06:00:29Z |
| publishDate | 2022-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Translational Autoimmunity |
| spelling | doaj.art-0fd7fd7a2146472e9a5a2072d5e0bc9f2022-12-22T04:41:43ZengElsevierJournal of Translational Autoimmunity2589-90902022-01-015100154SARS-Cov2 acute and post-active infection in the context of autoimmune and chronic inflammatory diseasesRegina Larionova0K. Byvaltsev1Оlga Kravtsova2Elena Takha3Sergei Petrov4Gevorg Kazarian5Anna Valeeva6Eduard Shuralev7Malik Mukminov8Yves Renaudineau9Marina Arleevskaya10Central Research Laboratory, Kazan State Medical Academy, Kazan, Russia; Institute of Fundamental Medicine and Biology, Kazan (Volga Region) Federal University, Kazan, RussiaInstitute of Fundamental Medicine, Kazan (Volga Region) Federal University, Kazan, RussiaInstitute of Fundamental Medicine and Biology, Kazan (Volga Region) Federal University, Kazan, RussiaCentral Research Laboratory, Kazan State Medical Academy, Kazan, RussiaCentral Research Laboratory, Kazan State Medical Academy, Kazan, Russia; Institute of Environmental Sciences, Kazan (Volga Region) Federal University, Kazan, RussiaCentral Research Laboratory, Kazan State Medical Academy, Kazan, RussiaCentral Research Laboratory, Kazan State Medical Academy, Kazan, RussiaCentral Research Laboratory, Kazan State Medical Academy, Kazan, Russia; Institute of Environmental Sciences, Kazan (Volga Region) Federal University, Kazan, Russia; Kazan State Academy of Veterinary Medicine Named After N.E. Bauman, Kazan, RussiaCentral Research Laboratory, Kazan State Medical Academy, Kazan, Russia; Institute of Environmental Sciences, Kazan (Volga Region) Federal University, Kazan, RussiaCentral Research Laboratory, Kazan State Medical Academy, Kazan, Russia; Laboratory of Immunology, CHU Purpan Toulouse, INSERM U1291, CNRS U5051, University Toulouse III, Toulouse, France; Corresponding author. Institut Fédératif de Biologie, Laboratoire d'immunologie, CHU Purpan, 330 avenue de Grande Bretagne, 31000, Toulouse, France.Central Research Laboratory, Kazan State Medical Academy, Kazan, Russia; Institute of Fundamental Medicine and Biology, Kazan (Volga Region) Federal University, Kazan, RussiaThe clinical and immunological spectrum of acute and post-active COVID-19 syndrome overlaps with criteria used to characterize autoimmune diseases such as rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). Indeed, following SARS-Cov2 infection, the innate immune response is altered with an initial delayed production of interferon type I (IFN–I), while the NF-kappa B and inflammasome pathways are activated. In lung and digestive tissues, an alternative and extrafollicular immune response against SARS-Cov2 takes place with, consequently, an altered humoral and memory T cell response leading to breakdown of tolerance with the emergence of autoantibodies. However, the risk of developing severe COVID-19 among SLE and RA patients did not exceed the general population except in those having pre-existing neutralizing autoantibodies against IFN-I. Treatment discontinuation rather than COVID-19 infection or vaccination increases the risk of developing flares. Last but not least, a limited number of case reports of individuals having developed SLE or RA following COVID-19 infection/vaccination have been reported. Altogether, the SARS-Cov2 pandemic represents an unique opportunity to investigate the dangerous interplay between the immune response against infectious agents and autoimmunity, and to better understand the triggering role of infection as a risk factor in autoimmune and chronic inflammatory disease development.http://www.sciencedirect.com/science/article/pii/S2589909022000156SARS-Cov2InfectionRheumatoid arthritisSystemic lupus erythematosusRisk factorsInflammation |
| spellingShingle | Regina Larionova K. Byvaltsev Оlga Kravtsova Elena Takha Sergei Petrov Gevorg Kazarian Anna Valeeva Eduard Shuralev Malik Mukminov Yves Renaudineau Marina Arleevskaya SARS-Cov2 acute and post-active infection in the context of autoimmune and chronic inflammatory diseases Journal of Translational Autoimmunity SARS-Cov2 Infection Rheumatoid arthritis Systemic lupus erythematosus Risk factors Inflammation |
| title | SARS-Cov2 acute and post-active infection in the context of autoimmune and chronic inflammatory diseases |
| title_full | SARS-Cov2 acute and post-active infection in the context of autoimmune and chronic inflammatory diseases |
| title_fullStr | SARS-Cov2 acute and post-active infection in the context of autoimmune and chronic inflammatory diseases |
| title_full_unstemmed | SARS-Cov2 acute and post-active infection in the context of autoimmune and chronic inflammatory diseases |
| title_short | SARS-Cov2 acute and post-active infection in the context of autoimmune and chronic inflammatory diseases |
| title_sort | sars cov2 acute and post active infection in the context of autoimmune and chronic inflammatory diseases |
| topic | SARS-Cov2 Infection Rheumatoid arthritis Systemic lupus erythematosus Risk factors Inflammation |
| url | http://www.sciencedirect.com/science/article/pii/S2589909022000156 |
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