Disruption of Claudin-1 Expression by miRNA-182 Alters the Susceptibility to Viral Infectivity in HCV Cell Models

Disruption of Claudin-1 Expression by miRNA-182 Alters the Susceptibility to Viral Infectivity in HCV Cell Models

HCV entry involves a complex interplay between viral and host molecules. During post-binding interactions, the viral E2 complexes with CD81 receptor for delivery to the tight junction proteins CLDN1 and OCLN, which aid in viral internalization. Targeting HCV entry receptors represents an appealing a...

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Bibliographic Details
Main Authors: Sarah E. Riad, Dalia S. Elhelw, Heba Shawer, Nada El-Ekiaby, Ayman Salah, Abdelrahman Zekri, Gamal Esmat, Asma Amleh, Ahmed I. Abdelaziz
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-03-01
Series:Frontiers in Genetics
Subjects:
hepatitis C virus
microRNA
entry inhibitors
Claudin-1
infection
Online Access:http://journal.frontiersin.org/article/10.3389/fgene.2018.00093/full

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