Pseudomonas aeruginosa infections: factors relating to mortality with emphasis on resistance pattern and antimicrobial treatment
A retrospective case-control study was conducted to investigate the risk factors for death among intensive care unit patients with Pseudomonas aeruginosa infection. Out of 131 patients investigated, 67 (51.1%) died within 30 days of being diagnosed with this infection. The mean duration of hospital...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
|
| Series: | Brazilian Journal of Infectious Diseases |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000600013&lng=en&tlng=en |
| _version_ | 1818272562791055360 |
|---|---|
| author | Millena R.S. Pinheiro Heloisa R. Lacerda Renata G.L. Melo Mª Amélia Maciel |
| author_facet | Millena R.S. Pinheiro Heloisa R. Lacerda Renata G.L. Melo Mª Amélia Maciel |
| author_sort | Millena R.S. Pinheiro |
| collection | DOAJ |
| description | A retrospective case-control study was conducted to investigate the risk factors for death among intensive care unit patients with Pseudomonas aeruginosa infection. Out of 131 patients investigated, 67 (51.1%) died within 30 days of being diagnosed with this infection. The mean duration of hospital stay before this diagnosis was 28.5 ± 26.5 days. No association was found between bacterial resistance and death in this study (multiresistant p= 0.26; panresistant p= 0.42), but the adequacy of the initial treatment was inversely proportional to the degree of resistance. There was a tendency towards greater mortality among patients who received combination therapy (empirical p= 0.09; definitive p= 0.08), despite the greater frequency of appropriate treatment in these patients and the similar degree of severity in the two groups. This finding may be explained by pharmacodynamic parameters that were not studied or by the extensive use of aminoglycosides in the combination therapy, which play a controversial role in combination therapy due to their potential for renal toxicity. The multivariate analysis in our study demonstrated that age [odds ratio (OR) 1.04], septic shock (OR 15.4) and hypoalbuminemia (OR 0.32) were independent risk factors for death. |
| first_indexed | 2024-12-12T21:44:03Z |
| format | Article |
| id | doaj.art-0fd93ca7add549b3bf6e03d8b5d12f57 |
| institution | Directory Open Access Journal |
| issn | 1678-4391 |
| language | English |
| last_indexed | 2024-12-12T21:44:03Z |
| publisher | Elsevier |
| record_format | Article |
| series | Brazilian Journal of Infectious Diseases |
| spelling | doaj.art-0fd93ca7add549b3bf6e03d8b5d12f572022-12-22T00:10:58ZengElsevierBrazilian Journal of Infectious Diseases1678-439112650951510.1590/S1413-86702008000600013S1413-86702008000600013Pseudomonas aeruginosa infections: factors relating to mortality with emphasis on resistance pattern and antimicrobial treatmentMillena R.S. Pinheiro0Heloisa R. Lacerda1Renata G.L. Melo2Mª Amélia Maciel3Universidade Federal de PernambucoUniversidade Federal de PernambucoHospital ProntolindaUniversidade Federal de PernambucoA retrospective case-control study was conducted to investigate the risk factors for death among intensive care unit patients with Pseudomonas aeruginosa infection. Out of 131 patients investigated, 67 (51.1%) died within 30 days of being diagnosed with this infection. The mean duration of hospital stay before this diagnosis was 28.5 ± 26.5 days. No association was found between bacterial resistance and death in this study (multiresistant p= 0.26; panresistant p= 0.42), but the adequacy of the initial treatment was inversely proportional to the degree of resistance. There was a tendency towards greater mortality among patients who received combination therapy (empirical p= 0.09; definitive p= 0.08), despite the greater frequency of appropriate treatment in these patients and the similar degree of severity in the two groups. This finding may be explained by pharmacodynamic parameters that were not studied or by the extensive use of aminoglycosides in the combination therapy, which play a controversial role in combination therapy due to their potential for renal toxicity. The multivariate analysis in our study demonstrated that age [odds ratio (OR) 1.04], septic shock (OR 15.4) and hypoalbuminemia (OR 0.32) were independent risk factors for death.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000600013&lng=en&tlng=enRisk factorsCase-control studyPseudomonas aeruginosaDeath |
| spellingShingle | Millena R.S. Pinheiro Heloisa R. Lacerda Renata G.L. Melo Mª Amélia Maciel Pseudomonas aeruginosa infections: factors relating to mortality with emphasis on resistance pattern and antimicrobial treatment Brazilian Journal of Infectious Diseases Risk factors Case-control study Pseudomonas aeruginosa Death |
| title | Pseudomonas aeruginosa infections: factors relating to mortality with emphasis on resistance pattern and antimicrobial treatment |
| title_full | Pseudomonas aeruginosa infections: factors relating to mortality with emphasis on resistance pattern and antimicrobial treatment |
| title_fullStr | Pseudomonas aeruginosa infections: factors relating to mortality with emphasis on resistance pattern and antimicrobial treatment |
| title_full_unstemmed | Pseudomonas aeruginosa infections: factors relating to mortality with emphasis on resistance pattern and antimicrobial treatment |
| title_short | Pseudomonas aeruginosa infections: factors relating to mortality with emphasis on resistance pattern and antimicrobial treatment |
| title_sort | pseudomonas aeruginosa infections factors relating to mortality with emphasis on resistance pattern and antimicrobial treatment |
| topic | Risk factors Case-control study Pseudomonas aeruginosa Death |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000600013&lng=en&tlng=en |
| work_keys_str_mv | AT millenarspinheiro pseudomonasaeruginosainfectionsfactorsrelatingtomortalitywithemphasisonresistancepatternandantimicrobialtreatment AT heloisarlacerda pseudomonasaeruginosainfectionsfactorsrelatingtomortalitywithemphasisonresistancepatternandantimicrobialtreatment AT renataglmelo pseudomonasaeruginosainfectionsfactorsrelatingtomortalitywithemphasisonresistancepatternandantimicrobialtreatment AT maameliamaciel pseudomonasaeruginosainfectionsfactorsrelatingtomortalitywithemphasisonresistancepatternandantimicrobialtreatment |