Application of Electrospun Drug-Loaded Nanofibers in Cancer Therapy
In the 21st century, chemotherapy stands as a primary treatment method for prevalent diseases, yet drug resistance remains a pressing challenge. Utilizing electrospinning to support chemotherapy drugs offers sustained and controlled release methods in contrast to oral and implantable drug delivery m...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-02-01
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| Series: | Polymers |
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| Online Access: | https://www.mdpi.com/2073-4360/16/4/504 |
| _version_ | 1797297115229061120 |
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| author | Yaoyao Yang Rui Zhang Zhiyuan Liang Junli Guo Bingying Chen Shengwei Zhou Dengguang Yu |
| author_facet | Yaoyao Yang Rui Zhang Zhiyuan Liang Junli Guo Bingying Chen Shengwei Zhou Dengguang Yu |
| author_sort | Yaoyao Yang |
| collection | DOAJ |
| description | In the 21st century, chemotherapy stands as a primary treatment method for prevalent diseases, yet drug resistance remains a pressing challenge. Utilizing electrospinning to support chemotherapy drugs offers sustained and controlled release methods in contrast to oral and implantable drug delivery modes, which enable localized treatment of distinct tumor types. Moreover, the core–sheath structure in electrospinning bears advantages in dual-drug loading: the core and sheath layers can carry different drugs, facilitating collaborative treatment to counter chemotherapy drug resistance. This approach minimizes patient discomfort associated with multiple-drug administration. Electrospun fibers not only transport drugs but can also integrate metal particles and targeted compounds, enabling combinations of chemotherapy with magnetic and heat therapies for comprehensive cancer treatment. This review delves into electrospinning preparation techniques and drug delivery methods tailored to various cancers, foreseeing their promising roles in cancer treatment. |
| first_indexed | 2024-03-07T22:16:33Z |
| format | Article |
| id | doaj.art-0fd96c7c59a84e0c8c956048568938b7 |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-03-07T22:16:33Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polymers |
| spelling | doaj.art-0fd96c7c59a84e0c8c956048568938b72024-02-23T15:32:17ZengMDPI AGPolymers2073-43602024-02-0116450410.3390/polym16040504Application of Electrospun Drug-Loaded Nanofibers in Cancer TherapyYaoyao Yang0Rui Zhang1Zhiyuan Liang2Junli Guo3Bingying Chen4Shengwei Zhou5Dengguang Yu6School of Materials and Chemistry, University of Shanghai for Science and Technology, 516 Jungong Road, Shanghai 200093, ChinaSchool of Materials and Chemistry, University of Shanghai for Science and Technology, 516 Jungong Road, Shanghai 200093, ChinaSchool of Materials and Chemistry, University of Shanghai for Science and Technology, 516 Jungong Road, Shanghai 200093, ChinaSchool of Materials and Chemistry, University of Shanghai for Science and Technology, 516 Jungong Road, Shanghai 200093, ChinaSchool of Materials and Chemistry, University of Shanghai for Science and Technology, 516 Jungong Road, Shanghai 200093, ChinaSchool of Materials and Chemistry, University of Shanghai for Science and Technology, 516 Jungong Road, Shanghai 200093, ChinaSchool of Materials and Chemistry, University of Shanghai for Science and Technology, 516 Jungong Road, Shanghai 200093, ChinaIn the 21st century, chemotherapy stands as a primary treatment method for prevalent diseases, yet drug resistance remains a pressing challenge. Utilizing electrospinning to support chemotherapy drugs offers sustained and controlled release methods in contrast to oral and implantable drug delivery modes, which enable localized treatment of distinct tumor types. Moreover, the core–sheath structure in electrospinning bears advantages in dual-drug loading: the core and sheath layers can carry different drugs, facilitating collaborative treatment to counter chemotherapy drug resistance. This approach minimizes patient discomfort associated with multiple-drug administration. Electrospun fibers not only transport drugs but can also integrate metal particles and targeted compounds, enabling combinations of chemotherapy with magnetic and heat therapies for comprehensive cancer treatment. This review delves into electrospinning preparation techniques and drug delivery methods tailored to various cancers, foreseeing their promising roles in cancer treatment.https://www.mdpi.com/2073-4360/16/4/504electrospinningnanofibersnanostructuredrug releasecancer therapy |
| spellingShingle | Yaoyao Yang Rui Zhang Zhiyuan Liang Junli Guo Bingying Chen Shengwei Zhou Dengguang Yu Application of Electrospun Drug-Loaded Nanofibers in Cancer Therapy Polymers electrospinning nanofibers nanostructure drug release cancer therapy |
| title | Application of Electrospun Drug-Loaded Nanofibers in Cancer Therapy |
| title_full | Application of Electrospun Drug-Loaded Nanofibers in Cancer Therapy |
| title_fullStr | Application of Electrospun Drug-Loaded Nanofibers in Cancer Therapy |
| title_full_unstemmed | Application of Electrospun Drug-Loaded Nanofibers in Cancer Therapy |
| title_short | Application of Electrospun Drug-Loaded Nanofibers in Cancer Therapy |
| title_sort | application of electrospun drug loaded nanofibers in cancer therapy |
| topic | electrospinning nanofibers nanostructure drug release cancer therapy |
| url | https://www.mdpi.com/2073-4360/16/4/504 |
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