Understanding complex functional wiring patterns in major depressive disorder through brain functional connectome
Abstract Brain function relies on efficient communications between distinct brain systems. The pathology of major depressive disorder (MDD) damages functional brain networks, resulting in cognitive impairment. Here, we reviewed the associations between brain functional connectome changes and MDD pat...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2021-10-01
|
| Series: | Translational Psychiatry |
| Online Access: | https://doi.org/10.1038/s41398-021-01646-7 |
| _version_ | 1819043343111290880 |
|---|---|
| author | Zhiyun Yang Lingyu Jian Hui Qiu Chaoqing Zhang Song Cheng Junjun Ji Ting Li Yu Wang Junfeng Li Kefeng Li |
| author_facet | Zhiyun Yang Lingyu Jian Hui Qiu Chaoqing Zhang Song Cheng Junjun Ji Ting Li Yu Wang Junfeng Li Kefeng Li |
| author_sort | Zhiyun Yang |
| collection | DOAJ |
| description | Abstract Brain function relies on efficient communications between distinct brain systems. The pathology of major depressive disorder (MDD) damages functional brain networks, resulting in cognitive impairment. Here, we reviewed the associations between brain functional connectome changes and MDD pathogenesis. We also highlighted the utility of brain functional connectome for differentiating MDD from other similar psychiatric disorders, predicting recurrence and suicide attempts in MDD, and evaluating treatment responses. Converging evidence has now linked aberrant brain functional network organization in MDD to the dysregulation of neurotransmitter signaling and neuroplasticity, providing insights into the neurobiological mechanisms of the disease and antidepressant efficacy. Widespread connectome dysfunctions in MDD patients include multiple, large-scale brain networks as well as local disturbances in brain circuits associated with negative and positive valence systems and cognitive functions. Although the clinical utility of the brain functional connectome remains to be realized, recent findings provide further promise that research in this area may lead to improved diagnosis, treatments, and clinical outcomes of MDD. |
| first_indexed | 2024-12-21T09:55:16Z |
| format | Article |
| id | doaj.art-0fd996b790014e3197e4a2618c4d1ab0 |
| institution | Directory Open Access Journal |
| issn | 2158-3188 |
| language | English |
| last_indexed | 2024-12-21T09:55:16Z |
| publishDate | 2021-10-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Translational Psychiatry |
| spelling | doaj.art-0fd996b790014e3197e4a2618c4d1ab02022-12-21T19:08:05ZengNature Publishing GroupTranslational Psychiatry2158-31882021-10-0111111410.1038/s41398-021-01646-7Understanding complex functional wiring patterns in major depressive disorder through brain functional connectomeZhiyun Yang0Lingyu Jian1Hui Qiu2Chaoqing Zhang3Song Cheng4Junjun Ji5Ting Li6Yu Wang7Junfeng Li8Kefeng Li9Department of Radiology, Heping Hospital Affiliated to Changzhi Medical CollegeDepartment of Radiology, Heping Hospital Affiliated to Changzhi Medical CollegeHuaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan UniversityDepartment of Radiology, Heping Hospital Affiliated to Changzhi Medical CollegeDepartment of Radiology, Heping Hospital Affiliated to Changzhi Medical CollegeDepartment of Radiology, Heping Hospital Affiliated to Changzhi Medical CollegeDepartment of Radiology, Heping Hospital Affiliated to Changzhi Medical CollegeDepartment of Psychiatry, Changzhi Mental Health CenterDepartment of Radiology, Heping Hospital Affiliated to Changzhi Medical CollegeSchool of Medicine, University of CaliforniaAbstract Brain function relies on efficient communications between distinct brain systems. The pathology of major depressive disorder (MDD) damages functional brain networks, resulting in cognitive impairment. Here, we reviewed the associations between brain functional connectome changes and MDD pathogenesis. We also highlighted the utility of brain functional connectome for differentiating MDD from other similar psychiatric disorders, predicting recurrence and suicide attempts in MDD, and evaluating treatment responses. Converging evidence has now linked aberrant brain functional network organization in MDD to the dysregulation of neurotransmitter signaling and neuroplasticity, providing insights into the neurobiological mechanisms of the disease and antidepressant efficacy. Widespread connectome dysfunctions in MDD patients include multiple, large-scale brain networks as well as local disturbances in brain circuits associated with negative and positive valence systems and cognitive functions. Although the clinical utility of the brain functional connectome remains to be realized, recent findings provide further promise that research in this area may lead to improved diagnosis, treatments, and clinical outcomes of MDD.https://doi.org/10.1038/s41398-021-01646-7 |
| spellingShingle | Zhiyun Yang Lingyu Jian Hui Qiu Chaoqing Zhang Song Cheng Junjun Ji Ting Li Yu Wang Junfeng Li Kefeng Li Understanding complex functional wiring patterns in major depressive disorder through brain functional connectome Translational Psychiatry |
| title | Understanding complex functional wiring patterns in major depressive disorder through brain functional connectome |
| title_full | Understanding complex functional wiring patterns in major depressive disorder through brain functional connectome |
| title_fullStr | Understanding complex functional wiring patterns in major depressive disorder through brain functional connectome |
| title_full_unstemmed | Understanding complex functional wiring patterns in major depressive disorder through brain functional connectome |
| title_short | Understanding complex functional wiring patterns in major depressive disorder through brain functional connectome |
| title_sort | understanding complex functional wiring patterns in major depressive disorder through brain functional connectome |
| url | https://doi.org/10.1038/s41398-021-01646-7 |
| work_keys_str_mv | AT zhiyunyang understandingcomplexfunctionalwiringpatternsinmajordepressivedisorderthroughbrainfunctionalconnectome AT lingyujian understandingcomplexfunctionalwiringpatternsinmajordepressivedisorderthroughbrainfunctionalconnectome AT huiqiu understandingcomplexfunctionalwiringpatternsinmajordepressivedisorderthroughbrainfunctionalconnectome AT chaoqingzhang understandingcomplexfunctionalwiringpatternsinmajordepressivedisorderthroughbrainfunctionalconnectome AT songcheng understandingcomplexfunctionalwiringpatternsinmajordepressivedisorderthroughbrainfunctionalconnectome AT junjunji understandingcomplexfunctionalwiringpatternsinmajordepressivedisorderthroughbrainfunctionalconnectome AT tingli understandingcomplexfunctionalwiringpatternsinmajordepressivedisorderthroughbrainfunctionalconnectome AT yuwang understandingcomplexfunctionalwiringpatternsinmajordepressivedisorderthroughbrainfunctionalconnectome AT junfengli understandingcomplexfunctionalwiringpatternsinmajordepressivedisorderthroughbrainfunctionalconnectome AT kefengli understandingcomplexfunctionalwiringpatternsinmajordepressivedisorderthroughbrainfunctionalconnectome |