The effect of intermittent versus continuous enteral feeding for critically ill patients: a meta-analysis of randomized controlled trials
ObjectivesThe appropriate strategy for enteral feeding in critically ill patients still remains controversial. Therefore, we conducted this meta-analysis to compare the effect of intermittent versus continuous enteral feeding method for critically ill patients.MethodsElectronic databases including P...
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Frontiers Media S.A.
2023-08-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2023.1214774/full |
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| author | Jing Qu Xiaoya Xu Chaobo Xu Xuzhong Ding Kai Zhang Leshuang Hu |
| author_facet | Jing Qu Xiaoya Xu Chaobo Xu Xuzhong Ding Kai Zhang Leshuang Hu |
| author_sort | Jing Qu |
| collection | DOAJ |
| description | ObjectivesThe appropriate strategy for enteral feeding in critically ill patients still remains controversial. Therefore, we conducted this meta-analysis to compare the effect of intermittent versus continuous enteral feeding method for critically ill patients.MethodsElectronic databases including PubMed, Embase, Scopus, and Cochrane Library were searched up to April 10th, 2023 for randomized controlled trials evaluating the effect of intermittent versus continuous enteral feeding for critically ill patients. The primary outcomes were feeding intolerances, including diarrhea, vomiting, distension, constipation, gastric retention, and aspiration pneumonia. The secondary outcomes were mortality in intensive care unit (ICU), length of stay in ICU, and achievement of nutritional goal.ResultsThirteen studies with a total of 884 patients were analyzed in this meta-analysis. Overall, the use of intermittent enteral feeding was associated with higher incidence of diarrhea (OR 1.66, 95%CI 1.13 to 2.43, I2 = 16%) and distension (OR 2.29, 95%CI 1.16 to 4.51, I2 = 0%), lower incidence of constipation (OR 0.58, 95%CI 0.37 to 0.90, I2 = 0%), and longer length of ICU stay (MD 1.09, 95%CI 0.53 to 1.64, I2 = 0%). Moreover, no significant difference was identified for other outcome measures.ConclusionIn critically ill patients, the implementation of intermittent enteral feeding was associated with higher incidence of diarrhea and distension, longer length of ICU stay, but lower occurrence of constipation. Nevertheless, the absence of sufficient high-quality randomized controlled clinical trials precludes any definitive conclusions regarding the optimal approach to enteral feeding in this population. There is an imperative need for more studies to further assess the efficacy of the two enteral feeding strategies. |
| first_indexed | 2024-03-12T14:09:20Z |
| format | Article |
| id | doaj.art-0fd99db7620c4bde973becc1c6698827 |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-03-12T14:09:20Z |
| publishDate | 2023-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj.art-0fd99db7620c4bde973becc1c66988272023-08-21T09:05:14ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2023-08-011010.3389/fnut.2023.12147741214774The effect of intermittent versus continuous enteral feeding for critically ill patients: a meta-analysis of randomized controlled trialsJing Qu0Xiaoya Xu1Chaobo Xu2Xuzhong Ding3Kai Zhang4Leshuang Hu5Department of General Surgery, Lishui People’s Hospital, Lishui, ChinaDepartment of General Surgery, Lishui People’s Hospital, Lishui, ChinaDepartment of General Surgery, Lishui People’s Hospital, Lishui, ChinaDepartment of General Surgery, Lishui People’s Hospital, Lishui, ChinaDepartment of Critical Care Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of General Surgery, Lishui People’s Hospital, Lishui, ChinaObjectivesThe appropriate strategy for enteral feeding in critically ill patients still remains controversial. Therefore, we conducted this meta-analysis to compare the effect of intermittent versus continuous enteral feeding method for critically ill patients.MethodsElectronic databases including PubMed, Embase, Scopus, and Cochrane Library were searched up to April 10th, 2023 for randomized controlled trials evaluating the effect of intermittent versus continuous enteral feeding for critically ill patients. The primary outcomes were feeding intolerances, including diarrhea, vomiting, distension, constipation, gastric retention, and aspiration pneumonia. The secondary outcomes were mortality in intensive care unit (ICU), length of stay in ICU, and achievement of nutritional goal.ResultsThirteen studies with a total of 884 patients were analyzed in this meta-analysis. Overall, the use of intermittent enteral feeding was associated with higher incidence of diarrhea (OR 1.66, 95%CI 1.13 to 2.43, I2 = 16%) and distension (OR 2.29, 95%CI 1.16 to 4.51, I2 = 0%), lower incidence of constipation (OR 0.58, 95%CI 0.37 to 0.90, I2 = 0%), and longer length of ICU stay (MD 1.09, 95%CI 0.53 to 1.64, I2 = 0%). Moreover, no significant difference was identified for other outcome measures.ConclusionIn critically ill patients, the implementation of intermittent enteral feeding was associated with higher incidence of diarrhea and distension, longer length of ICU stay, but lower occurrence of constipation. Nevertheless, the absence of sufficient high-quality randomized controlled clinical trials precludes any definitive conclusions regarding the optimal approach to enteral feeding in this population. There is an imperative need for more studies to further assess the efficacy of the two enteral feeding strategies.https://www.frontiersin.org/articles/10.3389/fnut.2023.1214774/fullintermittent feeding strategycontinuous feeding strategyenteral nutritioncritically illmeta - analysis |
| spellingShingle | Jing Qu Xiaoya Xu Chaobo Xu Xuzhong Ding Kai Zhang Leshuang Hu The effect of intermittent versus continuous enteral feeding for critically ill patients: a meta-analysis of randomized controlled trials Frontiers in Nutrition intermittent feeding strategy continuous feeding strategy enteral nutrition critically ill meta - analysis |
| title | The effect of intermittent versus continuous enteral feeding for critically ill patients: a meta-analysis of randomized controlled trials |
| title_full | The effect of intermittent versus continuous enteral feeding for critically ill patients: a meta-analysis of randomized controlled trials |
| title_fullStr | The effect of intermittent versus continuous enteral feeding for critically ill patients: a meta-analysis of randomized controlled trials |
| title_full_unstemmed | The effect of intermittent versus continuous enteral feeding for critically ill patients: a meta-analysis of randomized controlled trials |
| title_short | The effect of intermittent versus continuous enteral feeding for critically ill patients: a meta-analysis of randomized controlled trials |
| title_sort | effect of intermittent versus continuous enteral feeding for critically ill patients a meta analysis of randomized controlled trials |
| topic | intermittent feeding strategy continuous feeding strategy enteral nutrition critically ill meta - analysis |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2023.1214774/full |
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