Digoxin protects against intervertebral disc degeneration via TNF/NF-κB and LRP4 signaling

Digoxin protects against intervertebral disc degeneration via TNF/NF-κB and LRP4 signaling

BackgroundIntervertebral disc degeneration (IVDD) is a leading cause of low back pain (LBP). The pathological process of IVDD is associated with inflammatory reactions and extracellular matrix (ECM) disorders. Digoxin is widely used for treating heart failure, and it has been reported to have anti-i...

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Bibliographic Details
Main Authors: Qunbo Meng, Kaiwen Liu, Zhenchuan Liu, Jinbo Liu, Ziyu Tian, Shanshan Qin, Jianlu Wei, Lei Cheng
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-09-01
Series:Frontiers in Immunology
Subjects:
digoxin
intervertebral disc degeneration
TNF
LRP4
inflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1251517/full

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