Clinical management and acute exacerbations in patients with idiopathic pulmonary fibrosis in Spain: results from the OASIS study
Abstract Background Idiopathic pulmonary fibrosis (IPF) is a progressive disease associated with decline in lung function and poor prognosis entailing significant impairment in quality of life and high socioeconomic burden. The aim of this study was to characterize clinical management and resources...
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| Format: | Article |
| Language: | English |
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BMC
2022-09-01
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| Series: | Respiratory Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12931-022-02154-y |
| _version_ | 1811211760827367424 |
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| author | Esteban Cano-Jiménez Ana Dolores Romero Ortiz Ana Villar María Jesús Rodríguez-Nieto Alba Ramon Silvia Armengol |
| author_facet | Esteban Cano-Jiménez Ana Dolores Romero Ortiz Ana Villar María Jesús Rodríguez-Nieto Alba Ramon Silvia Armengol |
| author_sort | Esteban Cano-Jiménez |
| collection | DOAJ |
| description | Abstract Background Idiopathic pulmonary fibrosis (IPF) is a progressive disease associated with decline in lung function and poor prognosis entailing significant impairment in quality of life and high socioeconomic burden. The aim of this study was to characterize clinical management and resources utilization of patients with IPF in Spain, according to predicted forced vital capacity (FVC) % at baseline. Methods Prospective, non-interventional, multicentric real-world data study in patients with IPF in Spain with 12-months follow-up. Clinical management and resources utilization during study period were recorded and compared between groups. FVC decline and acute exacerbations occurrence and associated healthcare resource use were also analysed. FVC decline after 12 months was estimated as relative change. Results 204 consecutive patients with IPF were included and divided according to baseline FVC % predicted value. At baseline, patients with FVC < 50% received significantly more pharmacological and non-pharmacological treatments, and more help from caregiver. During the 12-months follow-up, patients with FVC < 50% required more specialized care visits, emergency visits, hospitalizations, pulmonary functions tests, non-health resource use (special transportation), and pharmacological treatments (p < 0.05 for all comparisons). Moreover, patients with FVC < 50% at baseline experienced more AE-IPF (p < 0.05), requiring more health-related resources use (primary care visits, p < 0.05). FVC decline was observed in all groups over the 12 months. FVC decreased on average by 2.50% (95% CI: − 5.98 to 0.98) along the year. More patients experienced an FVC decline > 10% in the more preserved lung function groups than in the FVC < 50% group, because of their already deteriorated condition. Conclusions We observed a significantly higher annual IPF-related resource use in patients with more impaired lung function at baseline. Since FVC decreases irrespective of FVC% predicted at baseline, slowing IPF progression to maintain patients at early disease stages is relevant to improve IPF management and to optimize resource use. Trial registration: EU PAS register number EUPAS19387 [June 01, 2017]. |
| first_indexed | 2024-04-12T05:17:42Z |
| format | Article |
| id | doaj.art-0fde410d6f4a40ac91788a13c62b5638 |
| institution | Directory Open Access Journal |
| issn | 1465-993X |
| language | English |
| last_indexed | 2024-04-12T05:17:42Z |
| publishDate | 2022-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Respiratory Research |
| spelling | doaj.art-0fde410d6f4a40ac91788a13c62b56382022-12-22T03:46:35ZengBMCRespiratory Research1465-993X2022-09-0123111310.1186/s12931-022-02154-yClinical management and acute exacerbations in patients with idiopathic pulmonary fibrosis in Spain: results from the OASIS studyEsteban Cano-Jiménez0Ana Dolores Romero Ortiz1Ana Villar2María Jesús Rodríguez-Nieto3Alba Ramon4Silvia Armengol5Servicio de Neumología, ILD Unit, Hospital Universitario Lucus AugustiServicio de Neumología, Hospital Universitario Virgen de Las NievesServei de Pneumologia, Hospital Universitari Vall d’HebronServicio de Neumología, IIS Fundación Jiménez Diaz, CIBERESBoehringer Ingelheim EspañaBoehringer Ingelheim EspañaAbstract Background Idiopathic pulmonary fibrosis (IPF) is a progressive disease associated with decline in lung function and poor prognosis entailing significant impairment in quality of life and high socioeconomic burden. The aim of this study was to characterize clinical management and resources utilization of patients with IPF in Spain, according to predicted forced vital capacity (FVC) % at baseline. Methods Prospective, non-interventional, multicentric real-world data study in patients with IPF in Spain with 12-months follow-up. Clinical management and resources utilization during study period were recorded and compared between groups. FVC decline and acute exacerbations occurrence and associated healthcare resource use were also analysed. FVC decline after 12 months was estimated as relative change. Results 204 consecutive patients with IPF were included and divided according to baseline FVC % predicted value. At baseline, patients with FVC < 50% received significantly more pharmacological and non-pharmacological treatments, and more help from caregiver. During the 12-months follow-up, patients with FVC < 50% required more specialized care visits, emergency visits, hospitalizations, pulmonary functions tests, non-health resource use (special transportation), and pharmacological treatments (p < 0.05 for all comparisons). Moreover, patients with FVC < 50% at baseline experienced more AE-IPF (p < 0.05), requiring more health-related resources use (primary care visits, p < 0.05). FVC decline was observed in all groups over the 12 months. FVC decreased on average by 2.50% (95% CI: − 5.98 to 0.98) along the year. More patients experienced an FVC decline > 10% in the more preserved lung function groups than in the FVC < 50% group, because of their already deteriorated condition. Conclusions We observed a significantly higher annual IPF-related resource use in patients with more impaired lung function at baseline. Since FVC decreases irrespective of FVC% predicted at baseline, slowing IPF progression to maintain patients at early disease stages is relevant to improve IPF management and to optimize resource use. Trial registration: EU PAS register number EUPAS19387 [June 01, 2017].https://doi.org/10.1186/s12931-022-02154-yIdiopathic pulmonary fibrosis (IPF)Clinical managementIPF acute exacerbationsIPF managementIPF progressionEarly treatment |
| spellingShingle | Esteban Cano-Jiménez Ana Dolores Romero Ortiz Ana Villar María Jesús Rodríguez-Nieto Alba Ramon Silvia Armengol Clinical management and acute exacerbations in patients with idiopathic pulmonary fibrosis in Spain: results from the OASIS study Respiratory Research Idiopathic pulmonary fibrosis (IPF) Clinical management IPF acute exacerbations IPF management IPF progression Early treatment |
| title | Clinical management and acute exacerbations in patients with idiopathic pulmonary fibrosis in Spain: results from the OASIS study |
| title_full | Clinical management and acute exacerbations in patients with idiopathic pulmonary fibrosis in Spain: results from the OASIS study |
| title_fullStr | Clinical management and acute exacerbations in patients with idiopathic pulmonary fibrosis in Spain: results from the OASIS study |
| title_full_unstemmed | Clinical management and acute exacerbations in patients with idiopathic pulmonary fibrosis in Spain: results from the OASIS study |
| title_short | Clinical management and acute exacerbations in patients with idiopathic pulmonary fibrosis in Spain: results from the OASIS study |
| title_sort | clinical management and acute exacerbations in patients with idiopathic pulmonary fibrosis in spain results from the oasis study |
| topic | Idiopathic pulmonary fibrosis (IPF) Clinical management IPF acute exacerbations IPF management IPF progression Early treatment |
| url | https://doi.org/10.1186/s12931-022-02154-y |
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