Does Therapeutic Exercise Support Improvement in Cognitive Function and Instrumental Activities of Daily Living in Patients with Mild Alzheimer’s Disease? A Randomized Controlled Trial
This randomized controlled trial aims to investigate the effect of 12 weeks of therapeutic exercise on cognitive function and daily activities in patients with mild Alzheimer’s disease (AD). A total of 171 patients with mild AD from the Amarousion Day Care Center of the Alzheimer Society of Athens a...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-07-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/13/7/1112 |
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| author | Vasileios Papatsimpas Sotiria Vrouva George Papathanasiou Marianna Papadopoulou Christina Bouzineki Sophia Kanellopoulou Dimitra Moutafi Daphne Bakalidou |
| author_facet | Vasileios Papatsimpas Sotiria Vrouva George Papathanasiou Marianna Papadopoulou Christina Bouzineki Sophia Kanellopoulou Dimitra Moutafi Daphne Bakalidou |
| author_sort | Vasileios Papatsimpas |
| collection | DOAJ |
| description | This randomized controlled trial aims to investigate the effect of 12 weeks of therapeutic exercise on cognitive function and daily activities in patients with mild Alzheimer’s disease (AD). A total of 171 patients with mild AD from the Amarousion Day Care Center of the Alzheimer Society of Athens and the Athens General Hospital “G. Gennimatas” were randomly divided into three groups. Group A (aerobic and resistance exercise, <i>n</i> = 57), group B (resistance exercise, <i>n</i> = 57), and group C (control group, <i>n</i> = 57). Group A followed a weekly program consisting of 5 days with 30 min walking and 3 days with resistance exercises for about 45 min. Group B followed only a resistance exercise program, the same as group A. Group C did not participate in any exercise program. After the intervention, cognitive function was assessed with the Cognitive Examination-Revised (ACE-R), Trail Making Test A-B (TMT A-B), and Digit Span Test Forward and Backward (DST F-B) and daily activities with the instrumental activities of daily living scale (IADLs). A significant intervention effect was observed for all outcome measures (global cognitive function and instrumental activities of daily living). ANCOVA Bonferroni corrected post hoc tests revealed that the aerobic and resistance group improved compared to the control group on all measurement scales. The resistance group also showed an improvement compared to the control group. No significant effects were found between the aerobic and resistance group and the resistance group in any of the outcome measures. |
| first_indexed | 2024-03-11T01:14:15Z |
| format | Article |
| id | doaj.art-0fe219737608485f94290fedf8b78782 |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-11T01:14:15Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-0fe219737608485f94290fedf8b787822023-11-18T18:35:33ZengMDPI AGBrain Sciences2076-34252023-07-01137111210.3390/brainsci13071112Does Therapeutic Exercise Support Improvement in Cognitive Function and Instrumental Activities of Daily Living in Patients with Mild Alzheimer’s Disease? A Randomized Controlled TrialVasileios Papatsimpas0Sotiria Vrouva1George Papathanasiou2Marianna Papadopoulou3Christina Bouzineki4Sophia Kanellopoulou5Dimitra Moutafi6Daphne Bakalidou7Physiotherapy Department, School of Health and Care Sciences, University of West Attica (UNIWA), 12243 Athens, GreecePhysiotherapy Department, School of Health and Care Sciences, University of West Attica (UNIWA), 12243 Athens, GreecePhysiotherapy Department, School of Health and Care Sciences, University of West Attica (UNIWA), 12243 Athens, GreecePhysiotherapy Department, School of Health and Care Sciences, University of West Attica (UNIWA), 12243 Athens, GreeceAlzheimer Athens Association, 11636 Athens, GreeceAlzheimer Athens Association, 11636 Athens, GreecePathological Department, General Hospital Konstantopouleio, 14233 Nea Ionia, GreecePhysiotherapy Department, School of Health and Care Sciences, University of West Attica (UNIWA), 12243 Athens, GreeceThis randomized controlled trial aims to investigate the effect of 12 weeks of therapeutic exercise on cognitive function and daily activities in patients with mild Alzheimer’s disease (AD). A total of 171 patients with mild AD from the Amarousion Day Care Center of the Alzheimer Society of Athens and the Athens General Hospital “G. Gennimatas” were randomly divided into three groups. Group A (aerobic and resistance exercise, <i>n</i> = 57), group B (resistance exercise, <i>n</i> = 57), and group C (control group, <i>n</i> = 57). Group A followed a weekly program consisting of 5 days with 30 min walking and 3 days with resistance exercises for about 45 min. Group B followed only a resistance exercise program, the same as group A. Group C did not participate in any exercise program. After the intervention, cognitive function was assessed with the Cognitive Examination-Revised (ACE-R), Trail Making Test A-B (TMT A-B), and Digit Span Test Forward and Backward (DST F-B) and daily activities with the instrumental activities of daily living scale (IADLs). A significant intervention effect was observed for all outcome measures (global cognitive function and instrumental activities of daily living). ANCOVA Bonferroni corrected post hoc tests revealed that the aerobic and resistance group improved compared to the control group on all measurement scales. The resistance group also showed an improvement compared to the control group. No significant effects were found between the aerobic and resistance group and the resistance group in any of the outcome measures.https://www.mdpi.com/2076-3425/13/7/1112dementiaAlzheimer’s diseasetherapeutic exerciseaerobic exerciseresistance exercisecognitive function |
| spellingShingle | Vasileios Papatsimpas Sotiria Vrouva George Papathanasiou Marianna Papadopoulou Christina Bouzineki Sophia Kanellopoulou Dimitra Moutafi Daphne Bakalidou Does Therapeutic Exercise Support Improvement in Cognitive Function and Instrumental Activities of Daily Living in Patients with Mild Alzheimer’s Disease? A Randomized Controlled Trial Brain Sciences dementia Alzheimer’s disease therapeutic exercise aerobic exercise resistance exercise cognitive function |
| title | Does Therapeutic Exercise Support Improvement in Cognitive Function and Instrumental Activities of Daily Living in Patients with Mild Alzheimer’s Disease? A Randomized Controlled Trial |
| title_full | Does Therapeutic Exercise Support Improvement in Cognitive Function and Instrumental Activities of Daily Living in Patients with Mild Alzheimer’s Disease? A Randomized Controlled Trial |
| title_fullStr | Does Therapeutic Exercise Support Improvement in Cognitive Function and Instrumental Activities of Daily Living in Patients with Mild Alzheimer’s Disease? A Randomized Controlled Trial |
| title_full_unstemmed | Does Therapeutic Exercise Support Improvement in Cognitive Function and Instrumental Activities of Daily Living in Patients with Mild Alzheimer’s Disease? A Randomized Controlled Trial |
| title_short | Does Therapeutic Exercise Support Improvement in Cognitive Function and Instrumental Activities of Daily Living in Patients with Mild Alzheimer’s Disease? A Randomized Controlled Trial |
| title_sort | does therapeutic exercise support improvement in cognitive function and instrumental activities of daily living in patients with mild alzheimer s disease a randomized controlled trial |
| topic | dementia Alzheimer’s disease therapeutic exercise aerobic exercise resistance exercise cognitive function |
| url | https://www.mdpi.com/2076-3425/13/7/1112 |
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