Risk of lung cancer in patients with gastro-esophageal reflux disease: a population-based cohort study
This large-scale, controlled cohort study estimated the risks of lung cancer in patients with gastro-esophageal reflux disease (GERD) in Taiwan. We conducted this population-based study using data from the National Health Insurance Research Database of Taiwan during the period from 1997 to 2010. Pat...
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PeerJ Inc.
2016-12-01
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| Online Access: | https://peerj.com/articles/2753.pdf |
| _version_ | 1827608848910778368 |
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| author | Chi-Kuei Hsu Chih-Cheng Lai Kun Wang Likwang Chen |
| author_facet | Chi-Kuei Hsu Chih-Cheng Lai Kun Wang Likwang Chen |
| author_sort | Chi-Kuei Hsu |
| collection | DOAJ |
| description | This large-scale, controlled cohort study estimated the risks of lung cancer in patients with gastro-esophageal reflux disease (GERD) in Taiwan. We conducted this population-based study using data from the National Health Insurance Research Database of Taiwan during the period from 1997 to 2010. Patients with GERD were diagnosed using endoscopy, and controls were matched to patients with GERD at a ratio of 1:4. We identified 15,412 patients with GERD and 60,957 controls. Compared with the controls, the patients with GERD had higher rates of osteoporosis, diabetes mellitus, asthma, chronic obstructive pulmonary disease, pneumonia, bronchiectasis, depression, anxiety, hypertension, dyslipidemia, chronic liver disease, congestive heart failure, atrial fibrillation, stroke, chronic kidney disease, and coronary artery disease (all P < .05). A total of 85 patients had lung cancer among patients with GERD during the follow-up of 42,555 person-years, and the rate of lung cancer was 0.0020 per person-year. By contrast, 232 patients had lung cancer among patients without GERD during the follow-up of 175,319 person-years, and the rate of lung cancer was 0.0013 per person-year. By using stepwise Cox regression model, the overall incidence of lung cancer remained significantly higher in the patients with GERD than in the controls (hazard ratio, 1.53; 95% CI [1.19–1.98]). The cumulative incidence of lung cancer was higher in the patients with GERD than in the controls (P = .0012). In conclusion, our large population-based cohort study provides evidence that GERD may increase the risk of lung cancer in Asians. |
| first_indexed | 2024-03-09T07:21:32Z |
| format | Article |
| id | doaj.art-0fe21cf8e4c84b6b9a1353a65256f19a |
| institution | Directory Open Access Journal |
| issn | 2167-8359 |
| language | English |
| last_indexed | 2024-03-09T07:21:32Z |
| publishDate | 2016-12-01 |
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| spelling | doaj.art-0fe21cf8e4c84b6b9a1353a65256f19a2023-12-03T07:15:14ZengPeerJ Inc.PeerJ2167-83592016-12-014e275310.7717/peerj.2753Risk of lung cancer in patients with gastro-esophageal reflux disease: a population-based cohort studyChi-Kuei Hsu0Chih-Cheng Lai1Kun Wang2Likwang Chen3Department of Internal Medicine, E-Da Hospital, Kaohsiung, TaiwanDepartment of Intensive Care Medicine, Chi Mei Medical Center, Liouying, Tainan, TaiwanDepartment of Internal Medicine, Cardinal Tien Hospital, New Taipei City, TaiwanNational Health Research Institutes, Miaoli, TaiwanThis large-scale, controlled cohort study estimated the risks of lung cancer in patients with gastro-esophageal reflux disease (GERD) in Taiwan. We conducted this population-based study using data from the National Health Insurance Research Database of Taiwan during the period from 1997 to 2010. Patients with GERD were diagnosed using endoscopy, and controls were matched to patients with GERD at a ratio of 1:4. We identified 15,412 patients with GERD and 60,957 controls. Compared with the controls, the patients with GERD had higher rates of osteoporosis, diabetes mellitus, asthma, chronic obstructive pulmonary disease, pneumonia, bronchiectasis, depression, anxiety, hypertension, dyslipidemia, chronic liver disease, congestive heart failure, atrial fibrillation, stroke, chronic kidney disease, and coronary artery disease (all P < .05). A total of 85 patients had lung cancer among patients with GERD during the follow-up of 42,555 person-years, and the rate of lung cancer was 0.0020 per person-year. By contrast, 232 patients had lung cancer among patients without GERD during the follow-up of 175,319 person-years, and the rate of lung cancer was 0.0013 per person-year. By using stepwise Cox regression model, the overall incidence of lung cancer remained significantly higher in the patients with GERD than in the controls (hazard ratio, 1.53; 95% CI [1.19–1.98]). The cumulative incidence of lung cancer was higher in the patients with GERD than in the controls (P = .0012). In conclusion, our large population-based cohort study provides evidence that GERD may increase the risk of lung cancer in Asians.https://peerj.com/articles/2753.pdfLung cancerGERDRisk factors |
| spellingShingle | Chi-Kuei Hsu Chih-Cheng Lai Kun Wang Likwang Chen Risk of lung cancer in patients with gastro-esophageal reflux disease: a population-based cohort study PeerJ Lung cancer GERD Risk factors |
| title | Risk of lung cancer in patients with gastro-esophageal reflux disease: a population-based cohort study |
| title_full | Risk of lung cancer in patients with gastro-esophageal reflux disease: a population-based cohort study |
| title_fullStr | Risk of lung cancer in patients with gastro-esophageal reflux disease: a population-based cohort study |
| title_full_unstemmed | Risk of lung cancer in patients with gastro-esophageal reflux disease: a population-based cohort study |
| title_short | Risk of lung cancer in patients with gastro-esophageal reflux disease: a population-based cohort study |
| title_sort | risk of lung cancer in patients with gastro esophageal reflux disease a population based cohort study |
| topic | Lung cancer GERD Risk factors |
| url | https://peerj.com/articles/2753.pdf |
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