Syndrome of Irreversible Lithium-Effectuated NeuroToxicity
Lithium has a narrow therapeutic window. Frequent monitoring of both serum levels and clinical signs of toxicity is warranted because toxicity may be present even when concentrations are within the therapeutic range. We report the case of a man with lithium poisoning, with persistent neurologic sign...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Ordem dos Médicos
2017-02-01
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| Series: | Acta Médica Portuguesa |
| Subjects: | |
| Online Access: | http://actamedicaportuguesa.com/revista/index.php/amp/article/view/7907 |
| _version_ | 1811231294795808768 |
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| author | Ana Luísa Silva Carolina Ourique Filipe Martins Fernando Friões |
| author_facet | Ana Luísa Silva Carolina Ourique Filipe Martins Fernando Friões |
| author_sort | Ana Luísa Silva |
| collection | DOAJ |
| description | Lithium has a narrow therapeutic window. Frequent monitoring of both serum levels and clinical signs of toxicity is warranted because toxicity may be present even when concentrations are within the therapeutic range. We report the case of a man with lithium poisoning, with persistent neurologic signs and symptoms even after removal of lithium from circulation – a diagnosis of syndrome of irreversible lithium-effectuated neurotoxicity (SILENT) was made. |
| first_indexed | 2024-04-12T10:42:08Z |
| format | Article |
| id | doaj.art-0fe4a313ce594b54bb5f47df7260fa02 |
| institution | Directory Open Access Journal |
| issn | 0870-399X 1646-0758 |
| language | English |
| last_indexed | 2024-04-12T10:42:08Z |
| publishDate | 2017-02-01 |
| publisher | Ordem dos Médicos |
| record_format | Article |
| series | Acta Médica Portuguesa |
| spelling | doaj.art-0fe4a313ce594b54bb5f47df7260fa022022-12-22T03:36:33ZengOrdem dos MédicosActa Médica Portuguesa0870-399X1646-07582017-02-0130215115310.20344/amp.79074440Syndrome of Irreversible Lithium-Effectuated NeuroToxicityAna Luísa Silva0Carolina Ourique1Filipe Martins2Fernando Friões3Serviço de Medicina Interna. Centro Hospitalar de São João. Porto. Portugal.Serviço de Medicina Interna. Centro Hospitalar de São João. Porto. Portugal.Serviço de Medicina Interna. Centro Hospitalar de São João. Porto. Portugal.Unidade de Cuidados Intermédios de Medicina. Centro Hospitalar de São João. Porto. Portugal.Lithium has a narrow therapeutic window. Frequent monitoring of both serum levels and clinical signs of toxicity is warranted because toxicity may be present even when concentrations are within the therapeutic range. We report the case of a man with lithium poisoning, with persistent neurologic signs and symptoms even after removal of lithium from circulation – a diagnosis of syndrome of irreversible lithium-effectuated neurotoxicity (SILENT) was made.http://actamedicaportuguesa.com/revista/index.php/amp/article/view/7907Lítio/efeitos adversosSíndromes de Neurotoxicidade/etiologia |
| spellingShingle | Ana Luísa Silva Carolina Ourique Filipe Martins Fernando Friões Syndrome of Irreversible Lithium-Effectuated NeuroToxicity Acta Médica Portuguesa Lítio/efeitos adversos Síndromes de Neurotoxicidade/etiologia |
| title | Syndrome of Irreversible Lithium-Effectuated NeuroToxicity |
| title_full | Syndrome of Irreversible Lithium-Effectuated NeuroToxicity |
| title_fullStr | Syndrome of Irreversible Lithium-Effectuated NeuroToxicity |
| title_full_unstemmed | Syndrome of Irreversible Lithium-Effectuated NeuroToxicity |
| title_short | Syndrome of Irreversible Lithium-Effectuated NeuroToxicity |
| title_sort | syndrome of irreversible lithium effectuated neurotoxicity |
| topic | Lítio/efeitos adversos Síndromes de Neurotoxicidade/etiologia |
| url | http://actamedicaportuguesa.com/revista/index.php/amp/article/view/7907 |
| work_keys_str_mv | AT analuisasilva syndromeofirreversiblelithiumeffectuatedneurotoxicity AT carolinaourique syndromeofirreversiblelithiumeffectuatedneurotoxicity AT filipemartins syndromeofirreversiblelithiumeffectuatedneurotoxicity AT fernandofrioes syndromeofirreversiblelithiumeffectuatedneurotoxicity |