Development of Turmeric Oil—Loaded Chitosan/Alginate Nanocapsules for Cytotoxicity Enhancement against Breast Cancer
Turmeric oil (TO) exhibits various biological activities with limited therapeutic applications due to its instability, volatility, and poor water solubility. Here, we encapsulated TO in chitosan/alginate nanocapsules (CS/Alg-NCs) using o/w emulsification to enhance its physicochemical characteristic...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-04-01
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| Series: | Polymers |
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| Online Access: | https://www.mdpi.com/2073-4360/14/9/1835 |
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| author | Htet Htet Moe San Khent Primo Alcantara Bryan Paul I. Bulatao Waraluck Chaichompoo Nonthaneth Nalinratana Apichart Suksamrarn Opa Vajragupta Pranee Rojsitthisak Pornchai Rojsitthisak |
| author_facet | Htet Htet Moe San Khent Primo Alcantara Bryan Paul I. Bulatao Waraluck Chaichompoo Nonthaneth Nalinratana Apichart Suksamrarn Opa Vajragupta Pranee Rojsitthisak Pornchai Rojsitthisak |
| author_sort | Htet Htet Moe San |
| collection | DOAJ |
| description | Turmeric oil (TO) exhibits various biological activities with limited therapeutic applications due to its instability, volatility, and poor water solubility. Here, we encapsulated TO in chitosan/alginate nanocapsules (CS/Alg-NCs) using o/w emulsification to enhance its physicochemical characteristics, using poloxamer 407 as a non-ionic surfactant. TO-loaded CS/Alg-NCs (TO-CS/Alg-NCs) were prepared with satisfactory features, encapsulation efficiency, release characteristics, and cytotoxicity against breast cancer cells. The average size of the fabricated TO-CS/Alg-NCs was around 200 nm; their distribution was homogenous, and their shapes were spherical, with smooth surfaces. The TO-CS/Alg-NCs showed a high encapsulation efficiency, of 70%, with a sustained release of TO at approximately 50% after 12 h at pH 7.4 and 5.5. The TO-CS/Alg-NCs demonstrated enhanced cytotoxicity against two breast cancer cells, MDA-MB-231 and MCF-7, compared to the unencapsulated TO, suggesting that CS/Alg-NCs are potential nanocarriers for TO and can serve as prospective candidates for in vivo anticancer activity evaluation. |
| first_indexed | 2024-03-10T03:46:30Z |
| format | Article |
| id | doaj.art-0fe4ee78ee8d4d5d8e253b5b147a0b52 |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-03-10T03:46:30Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polymers |
| spelling | doaj.art-0fe4ee78ee8d4d5d8e253b5b147a0b522023-11-23T09:07:00ZengMDPI AGPolymers2073-43602022-04-01149183510.3390/polym14091835Development of Turmeric Oil—Loaded Chitosan/Alginate Nanocapsules for Cytotoxicity Enhancement against Breast CancerHtet Htet Moe San0Khent Primo Alcantara1Bryan Paul I. Bulatao2Waraluck Chaichompoo3Nonthaneth Nalinratana4Apichart Suksamrarn5Opa Vajragupta6Pranee Rojsitthisak7Pornchai Rojsitthisak8Pharmaceutical Sciences and Technology Program, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, ThailandPharmaceutical Sciences and Technology Program, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, ThailandPharmaceutical Sciences and Technology Program, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, ThailandCenter of Excellence in Natural Products for Ageing and Chronic Diseases, Chulalongkorn University, Bangkok 10330, ThailandCenter of Excellence in Natural Products for Ageing and Chronic Diseases, Chulalongkorn University, Bangkok 10330, ThailandDepartment of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Ramkhamhaeng University, Bangkok 10240, ThailandCenter of Excellence in Natural Products for Ageing and Chronic Diseases, Chulalongkorn University, Bangkok 10330, ThailandCenter of Excellence in Natural Products for Ageing and Chronic Diseases, Chulalongkorn University, Bangkok 10330, ThailandCenter of Excellence in Natural Products for Ageing and Chronic Diseases, Chulalongkorn University, Bangkok 10330, ThailandTurmeric oil (TO) exhibits various biological activities with limited therapeutic applications due to its instability, volatility, and poor water solubility. Here, we encapsulated TO in chitosan/alginate nanocapsules (CS/Alg-NCs) using o/w emulsification to enhance its physicochemical characteristics, using poloxamer 407 as a non-ionic surfactant. TO-loaded CS/Alg-NCs (TO-CS/Alg-NCs) were prepared with satisfactory features, encapsulation efficiency, release characteristics, and cytotoxicity against breast cancer cells. The average size of the fabricated TO-CS/Alg-NCs was around 200 nm; their distribution was homogenous, and their shapes were spherical, with smooth surfaces. The TO-CS/Alg-NCs showed a high encapsulation efficiency, of 70%, with a sustained release of TO at approximately 50% after 12 h at pH 7.4 and 5.5. The TO-CS/Alg-NCs demonstrated enhanced cytotoxicity against two breast cancer cells, MDA-MB-231 and MCF-7, compared to the unencapsulated TO, suggesting that CS/Alg-NCs are potential nanocarriers for TO and can serve as prospective candidates for in vivo anticancer activity evaluation.https://www.mdpi.com/2073-4360/14/9/1835<i>ar</i>-turmeronepolymeric nanoparticlesanticancer activityrelease studybiodegradable polymers |
| spellingShingle | Htet Htet Moe San Khent Primo Alcantara Bryan Paul I. Bulatao Waraluck Chaichompoo Nonthaneth Nalinratana Apichart Suksamrarn Opa Vajragupta Pranee Rojsitthisak Pornchai Rojsitthisak Development of Turmeric Oil—Loaded Chitosan/Alginate Nanocapsules for Cytotoxicity Enhancement against Breast Cancer Polymers <i>ar</i>-turmerone polymeric nanoparticles anticancer activity release study biodegradable polymers |
| title | Development of Turmeric Oil—Loaded Chitosan/Alginate Nanocapsules for Cytotoxicity Enhancement against Breast Cancer |
| title_full | Development of Turmeric Oil—Loaded Chitosan/Alginate Nanocapsules for Cytotoxicity Enhancement against Breast Cancer |
| title_fullStr | Development of Turmeric Oil—Loaded Chitosan/Alginate Nanocapsules for Cytotoxicity Enhancement against Breast Cancer |
| title_full_unstemmed | Development of Turmeric Oil—Loaded Chitosan/Alginate Nanocapsules for Cytotoxicity Enhancement against Breast Cancer |
| title_short | Development of Turmeric Oil—Loaded Chitosan/Alginate Nanocapsules for Cytotoxicity Enhancement against Breast Cancer |
| title_sort | development of turmeric oil loaded chitosan alginate nanocapsules for cytotoxicity enhancement against breast cancer |
| topic | <i>ar</i>-turmerone polymeric nanoparticles anticancer activity release study biodegradable polymers |
| url | https://www.mdpi.com/2073-4360/14/9/1835 |
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