Pea albumin extracted from pea (Pisum sativum L.) seed protects mice from high fat diet-induced obesity by modulating lipid metabolism and gut microbiota
Plant protein has been reported to play a key role in the prevention of obesity and associated complications. It is unknown whether pea albumin may exert anit-obesity and obesity-associated metabolic disorders alleviation. Pea albumin was isolated from pea seed (Pisum sativum L.) and determined its...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-10-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464622003048 |
| _version_ | 1828235480983928832 |
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| author | Ning Liu Zhuan Song Wenhua Jin Yue Yang Shiqiang Sun Yiquan Zhang Shucheng Zhang Siyuan Liu Fazheng Ren Pengjie Wang |
| author_facet | Ning Liu Zhuan Song Wenhua Jin Yue Yang Shiqiang Sun Yiquan Zhang Shucheng Zhang Siyuan Liu Fazheng Ren Pengjie Wang |
| author_sort | Ning Liu |
| collection | DOAJ |
| description | Plant protein has been reported to play a key role in the prevention of obesity and associated complications. It is unknown whether pea albumin may exert anit-obesity and obesity-associated metabolic disorders alleviation. Pea albumin was isolated from pea seed (Pisum sativum L.) and determined its functional role for anti-obesity and metabolic disorders alleviation in high fat diet (HFD)-fed mice. Pea albumin administration reduced body weight gain, improved glucose tolerance and insulin sensitivity, reduced inflammatory cytokines secretion, and alleviated hepatic steatosis in HFD-fed mice. Interestingly, pea albumin inhibited lipid accumulation in 3T3-L1 cells in vitro and modulated lipid metabolism by upregulating critical proteins implicated in lipolysis and fatty acid oxidation, and downregulating lipogenesis in vivo. Moreover, pea albumin restored gut microbial composition to normal fat diet condition and selectively promoted the growth of beneficial gut bacteria (Akkermansia, Parabacteroides etc.). Collectively, the data demonstrated that pea albumin protects mice from HFD-induced obesity and associated metabolic disorders. |
| first_indexed | 2024-04-12T20:14:27Z |
| format | Article |
| id | doaj.art-0fe831c345e34124b40182d677bedbd7 |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-04-12T20:14:27Z |
| publishDate | 2022-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-0fe831c345e34124b40182d677bedbd72022-12-22T03:18:09ZengElsevierJournal of Functional Foods1756-46462022-10-0197105234Pea albumin extracted from pea (Pisum sativum L.) seed protects mice from high fat diet-induced obesity by modulating lipid metabolism and gut microbiotaNing Liu0Zhuan Song1Wenhua Jin2Yue Yang3Shiqiang Sun4Yiquan Zhang5Shucheng Zhang6Siyuan Liu7Fazheng Ren8Pengjie Wang9Beijing Advanced Innovation Center for Food Nutrition and Human Health, Department of Nutrition and Health, China Agricultural University, Beijing 100193, China; Key Laboratory of Precision Nutrition and Food Quality, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China; State Key Laboratory of Animal Nutrition, Department of Animal Nutrition and Feed Science, China Agricultural University, Beijing 100193, ChinaBeijing Advanced Innovation Center for Food Nutrition and Human Health, Department of Nutrition and Health, China Agricultural University, Beijing 100193, China; State Key Laboratory of Animal Nutrition, Department of Animal Nutrition and Feed Science, China Agricultural University, Beijing 100193, ChinaBeijing Advanced Innovation Center for Food Nutrition and Human Health, Department of Nutrition and Health, China Agricultural University, Beijing 100193, ChinaBeijing Advanced Innovation Center for Food Nutrition and Human Health, Department of Nutrition and Health, China Agricultural University, Beijing 100193, ChinaDepartment of Gastroenterology and Hepatology, University of Groningen and University Medical Center Groningen, Groningen 9713ZG, NetherlandsBeijing Advanced Innovation Center for Food Nutrition and Human Health, Department of Nutrition and Health, China Agricultural University, Beijing 100193, ChinaBeijing Advanced Innovation Center for Food Nutrition and Human Health, Department of Nutrition and Health, China Agricultural University, Beijing 100193, China; Key Laboratory of Precision Nutrition and Food Quality, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, ChinaBeijing Advanced Innovation Center for Food Nutrition and Human Health, Department of Nutrition and Health, China Agricultural University, Beijing 100193, ChinaBeijing Advanced Innovation Center for Food Nutrition and Human Health, Department of Nutrition and Health, China Agricultural University, Beijing 100193, China; Corresponding authors.Beijing Advanced Innovation Center for Food Nutrition and Human Health, Department of Nutrition and Health, China Agricultural University, Beijing 100193, China; Corresponding authors.Plant protein has been reported to play a key role in the prevention of obesity and associated complications. It is unknown whether pea albumin may exert anit-obesity and obesity-associated metabolic disorders alleviation. Pea albumin was isolated from pea seed (Pisum sativum L.) and determined its functional role for anti-obesity and metabolic disorders alleviation in high fat diet (HFD)-fed mice. Pea albumin administration reduced body weight gain, improved glucose tolerance and insulin sensitivity, reduced inflammatory cytokines secretion, and alleviated hepatic steatosis in HFD-fed mice. Interestingly, pea albumin inhibited lipid accumulation in 3T3-L1 cells in vitro and modulated lipid metabolism by upregulating critical proteins implicated in lipolysis and fatty acid oxidation, and downregulating lipogenesis in vivo. Moreover, pea albumin restored gut microbial composition to normal fat diet condition and selectively promoted the growth of beneficial gut bacteria (Akkermansia, Parabacteroides etc.). Collectively, the data demonstrated that pea albumin protects mice from HFD-induced obesity and associated metabolic disorders.http://www.sciencedirect.com/science/article/pii/S1756464622003048Glucose toleranceGut microbiotaInsulin resistanceLipid metabolismMetabolic disorderObesity |
| spellingShingle | Ning Liu Zhuan Song Wenhua Jin Yue Yang Shiqiang Sun Yiquan Zhang Shucheng Zhang Siyuan Liu Fazheng Ren Pengjie Wang Pea albumin extracted from pea (Pisum sativum L.) seed protects mice from high fat diet-induced obesity by modulating lipid metabolism and gut microbiota Journal of Functional Foods Glucose tolerance Gut microbiota Insulin resistance Lipid metabolism Metabolic disorder Obesity |
| title | Pea albumin extracted from pea (Pisum sativum L.) seed protects mice from high fat diet-induced obesity by modulating lipid metabolism and gut microbiota |
| title_full | Pea albumin extracted from pea (Pisum sativum L.) seed protects mice from high fat diet-induced obesity by modulating lipid metabolism and gut microbiota |
| title_fullStr | Pea albumin extracted from pea (Pisum sativum L.) seed protects mice from high fat diet-induced obesity by modulating lipid metabolism and gut microbiota |
| title_full_unstemmed | Pea albumin extracted from pea (Pisum sativum L.) seed protects mice from high fat diet-induced obesity by modulating lipid metabolism and gut microbiota |
| title_short | Pea albumin extracted from pea (Pisum sativum L.) seed protects mice from high fat diet-induced obesity by modulating lipid metabolism and gut microbiota |
| title_sort | pea albumin extracted from pea pisum sativum l seed protects mice from high fat diet induced obesity by modulating lipid metabolism and gut microbiota |
| topic | Glucose tolerance Gut microbiota Insulin resistance Lipid metabolism Metabolic disorder Obesity |
| url | http://www.sciencedirect.com/science/article/pii/S1756464622003048 |
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