Cross-linked chitosan-dextran sulphate vehicle system for controlled release of ciprofloxaxin drug: An ophthalmic application
The major challenge associated with conventional eye-drop is the rapid drug loss due to precorneal defence barrier. In this context, controlled-release system of ciprofloxacin-conjugated chitosan (CS)-Dextran sulphate (DS) nanoparticles (NPs) have been synthesized, to increase the bioavailability. T...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2017-01-01
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| Series: | OpenNano |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352952017300014 |
| _version_ | 1818964899999514624 |
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| author | Chetan Chavan Preetam Bala Kavita Pal S.N. Kale |
| author_facet | Chetan Chavan Preetam Bala Kavita Pal S.N. Kale |
| author_sort | Chetan Chavan |
| collection | DOAJ |
| description | The major challenge associated with conventional eye-drop is the rapid drug loss due to precorneal defence barrier. In this context, controlled-release system of ciprofloxacin-conjugated chitosan (CS)-Dextran sulphate (DS) nanoparticles (NPs) have been synthesized, to increase the bioavailability. The formulated drug delivery vehicle was evaluated for its therapeutic value in the simulated tear fluidat pH 7.4. Ophthalmic microbes were tested with this formulation, to confirm the drug efficacy; which showed conducive therapeutic values of both MIC and MBC. Ocular irritancy test was performed using HET-CAM test, which showed that the CS-DS system did not yield any vascular response, offering it to be a non-irritant to the ocular surface. The release studies showed monotonous controlled-release for duration of 21 h. A fine cross-linking between CS and DS has been demonstrated to form CS-DS NPs and their interaction with drug has been evaluated using conventional characterization tools. |
| first_indexed | 2024-12-20T13:08:27Z |
| format | Article |
| id | doaj.art-0fe86587940f49b8a041086682e35a17 |
| institution | Directory Open Access Journal |
| issn | 2352-9520 |
| language | English |
| last_indexed | 2024-12-20T13:08:27Z |
| publishDate | 2017-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | OpenNano |
| spelling | doaj.art-0fe86587940f49b8a041086682e35a172022-12-21T19:39:44ZengElsevierOpenNano2352-95202017-01-012C283610.1016/j.onano.2017.04.002Cross-linked chitosan-dextran sulphate vehicle system for controlled release of ciprofloxaxin drug: An ophthalmic applicationChetan Chavan0Preetam Bala1Kavita Pal2S.N. Kale3Department of Biosciences and Technology, Defence Institute of Advanced Technology (DIAT), Girinagar, Pune 411025, IndiaDepartment of Biosciences and Technology, Defence Institute of Advanced Technology (DIAT), Girinagar, Pune 411025, IndiaTranslational Research Laboratory, Advance Centre for Treatment, Research and Education in Cancer (ACTREC), Kharghar, Navi Mumbai 410210, IndiaDepartment of Biosciences and Technology, Defence Institute of Advanced Technology (DIAT), Girinagar, Pune 411025, IndiaThe major challenge associated with conventional eye-drop is the rapid drug loss due to precorneal defence barrier. In this context, controlled-release system of ciprofloxacin-conjugated chitosan (CS)-Dextran sulphate (DS) nanoparticles (NPs) have been synthesized, to increase the bioavailability. The formulated drug delivery vehicle was evaluated for its therapeutic value in the simulated tear fluidat pH 7.4. Ophthalmic microbes were tested with this formulation, to confirm the drug efficacy; which showed conducive therapeutic values of both MIC and MBC. Ocular irritancy test was performed using HET-CAM test, which showed that the CS-DS system did not yield any vascular response, offering it to be a non-irritant to the ocular surface. The release studies showed monotonous controlled-release for duration of 21 h. A fine cross-linking between CS and DS has been demonstrated to form CS-DS NPs and their interaction with drug has been evaluated using conventional characterization tools.http://www.sciencedirect.com/science/article/pii/S2352952017300014ChitosanNanoparticlesOphthalmicCiprofloxacinSustained release |
| spellingShingle | Chetan Chavan Preetam Bala Kavita Pal S.N. Kale Cross-linked chitosan-dextran sulphate vehicle system for controlled release of ciprofloxaxin drug: An ophthalmic application OpenNano Chitosan Nanoparticles Ophthalmic Ciprofloxacin Sustained release |
| title | Cross-linked chitosan-dextran sulphate vehicle system for controlled release of ciprofloxaxin drug: An ophthalmic application |
| title_full | Cross-linked chitosan-dextran sulphate vehicle system for controlled release of ciprofloxaxin drug: An ophthalmic application |
| title_fullStr | Cross-linked chitosan-dextran sulphate vehicle system for controlled release of ciprofloxaxin drug: An ophthalmic application |
| title_full_unstemmed | Cross-linked chitosan-dextran sulphate vehicle system for controlled release of ciprofloxaxin drug: An ophthalmic application |
| title_short | Cross-linked chitosan-dextran sulphate vehicle system for controlled release of ciprofloxaxin drug: An ophthalmic application |
| title_sort | cross linked chitosan dextran sulphate vehicle system for controlled release of ciprofloxaxin drug an ophthalmic application |
| topic | Chitosan Nanoparticles Ophthalmic Ciprofloxacin Sustained release |
| url | http://www.sciencedirect.com/science/article/pii/S2352952017300014 |
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