Centenarian Exomes as a Tool for Evaluating the Clinical Relevance of Germline Tumor Suppressor Mutations

Centenarian Exomes as a Tool for Evaluating the Clinical Relevance of Germline Tumor Suppressor Mutations

Objectives: The aim of the present study was to evaluate the clinical relevance of mutations in tumor suppressor genes using whole-exome sequencing data from centenarians and young healthy individuals. Methods: Two pools, one of centenarians and one of young individuals, were constructed and whole-e...

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Main Authors: Lubomir Balabanski MSc, Dimitar Serbezov PhD, Dragomira Nikolova PhD, Olga Antonova PhD, Desislava Nesheva PhD, Zora Hammoudeh PhD, Radoslava Vazharova PhD, Sena Karachanak-Yankova PhD, Rada Staneva PhD, Marta Mihaylova PhD, Vera Damyanova PhD, Savina Hadjidekova PhD, Draga Toncheva PhD
Format: Article
Language:English
Published: SAGE Publishing 2020-03-01
Series:Technology in Cancer Research & Treatment
Online Access:https://doi.org/10.1177/1533033820911082

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