TelNet - a database for human and yeast genes involved in telomere maintenance
Abstract Background The ends of linear chromosomes, the telomeres, comprise repetitive DNA sequences in complex with proteins that protects them from being processed by the DNA repair machinery. Cancer cells need to counteract the shortening of telomere repeats during replication for their unlimited...
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| Format: | Article |
| Language: | English |
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BMC
2018-05-01
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| Series: | BMC Genetics |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12863-018-0617-8 |
| _version_ | 1828221168844275712 |
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| author | Delia M. Braun Inn Chung Nick Kepper Katharina I. Deeg Karsten Rippe |
| author_facet | Delia M. Braun Inn Chung Nick Kepper Katharina I. Deeg Karsten Rippe |
| author_sort | Delia M. Braun |
| collection | DOAJ |
| description | Abstract Background The ends of linear chromosomes, the telomeres, comprise repetitive DNA sequences in complex with proteins that protects them from being processed by the DNA repair machinery. Cancer cells need to counteract the shortening of telomere repeats during replication for their unlimited proliferation by reactivating the reverse transcriptase telomerase or by using the alternative lengthening of telomeres (ALT) pathway. The different telomere maintenance (TM) mechanisms appear to involve hundreds of proteins but their telomere repeat length related activities are only partly understood. Currently, a database that integrates information on TM relevant genes is missing. Description To provide a resource for studies that dissect TM features, we here introduce the TelNet database at http://www.cancertelsys.org/telnet/. It offers a comprehensive compilation of more than 2000 human and 1100 yeast genes linked to telomere maintenance. These genes were annotated in terms of TM mechanism, associated specific functions and orthologous genes, a TM significance score and information from peer-reviewed literature. This TM information can be retrieved via different search and view modes and evaluated for a set of genes as demonstrated for an exemplary application. Conclusion TelNet supports the annotation of genes identified from bioinformatics analysis pipelines to reveal possible connections with TM networks. We anticipate that TelNet will be a helpful resource for researchers that study telomeres. |
| first_indexed | 2024-04-12T16:37:15Z |
| format | Article |
| id | doaj.art-0fea98f1f5b64f77ba74765fe71065c6 |
| institution | Directory Open Access Journal |
| issn | 1471-2156 |
| language | English |
| last_indexed | 2024-04-12T16:37:15Z |
| publishDate | 2018-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Genetics |
| spelling | doaj.art-0fea98f1f5b64f77ba74765fe71065c62022-12-22T03:24:56ZengBMCBMC Genetics1471-21562018-05-0119111010.1186/s12863-018-0617-8TelNet - a database for human and yeast genes involved in telomere maintenanceDelia M. Braun0Inn Chung1Nick Kepper2Katharina I. Deeg3Karsten Rippe4Division of Chromatin Networks, German Cancer Research Center (DKFZ) & BioquantDivision of Chromatin Networks, German Cancer Research Center (DKFZ) & BioquantDivision of Chromatin Networks, German Cancer Research Center (DKFZ) & BioquantDivision of Chromatin Networks, German Cancer Research Center (DKFZ) & BioquantDivision of Chromatin Networks, German Cancer Research Center (DKFZ) & BioquantAbstract Background The ends of linear chromosomes, the telomeres, comprise repetitive DNA sequences in complex with proteins that protects them from being processed by the DNA repair machinery. Cancer cells need to counteract the shortening of telomere repeats during replication for their unlimited proliferation by reactivating the reverse transcriptase telomerase or by using the alternative lengthening of telomeres (ALT) pathway. The different telomere maintenance (TM) mechanisms appear to involve hundreds of proteins but their telomere repeat length related activities are only partly understood. Currently, a database that integrates information on TM relevant genes is missing. Description To provide a resource for studies that dissect TM features, we here introduce the TelNet database at http://www.cancertelsys.org/telnet/. It offers a comprehensive compilation of more than 2000 human and 1100 yeast genes linked to telomere maintenance. These genes were annotated in terms of TM mechanism, associated specific functions and orthologous genes, a TM significance score and information from peer-reviewed literature. This TM information can be retrieved via different search and view modes and evaluated for a set of genes as demonstrated for an exemplary application. Conclusion TelNet supports the annotation of genes identified from bioinformatics analysis pipelines to reveal possible connections with TM networks. We anticipate that TelNet will be a helpful resource for researchers that study telomeres.http://link.springer.com/article/10.1186/s12863-018-0617-8Telomere maintenanceTelomeraseAlternative lengthening of telomeres (ALT)Pathway analysis |
| spellingShingle | Delia M. Braun Inn Chung Nick Kepper Katharina I. Deeg Karsten Rippe TelNet - a database for human and yeast genes involved in telomere maintenance BMC Genetics Telomere maintenance Telomerase Alternative lengthening of telomeres (ALT) Pathway analysis |
| title | TelNet - a database for human and yeast genes involved in telomere maintenance |
| title_full | TelNet - a database for human and yeast genes involved in telomere maintenance |
| title_fullStr | TelNet - a database for human and yeast genes involved in telomere maintenance |
| title_full_unstemmed | TelNet - a database for human and yeast genes involved in telomere maintenance |
| title_short | TelNet - a database for human and yeast genes involved in telomere maintenance |
| title_sort | telnet a database for human and yeast genes involved in telomere maintenance |
| topic | Telomere maintenance Telomerase Alternative lengthening of telomeres (ALT) Pathway analysis |
| url | http://link.springer.com/article/10.1186/s12863-018-0617-8 |
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