Septo-Hippocampo-Septal Loop and Memory Formation
Cholinergic and GABAergic fibers in the medial septal/diagonal band of Broca (MS/DB) area project to the hippocampus and constitute the septo-hippocampal pathway, which has been proven in learning and memory. In addition, the hippocampus has bidirectional connections with the septum, which use this...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Iran University of Medical Sciences
2013-01-01
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| Series: | Basic and Clinical Neuroscience |
| Subjects: | |
| Online Access: | http://bcn.tums.ac.ir/browse.php?a_code=A-10-1-135&slc_lang=en&sid=1 |
| _version_ | 1797280968685387776 |
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| author | Fatemeh Khakpai Mohammad Nasehi Ali Haeri-Rohani Akram Eidi Mohammad Reza Zarrindast |
| author_facet | Fatemeh Khakpai Mohammad Nasehi Ali Haeri-Rohani Akram Eidi Mohammad Reza Zarrindast |
| author_sort | Fatemeh Khakpai |
| collection | DOAJ |
| description | Cholinergic and GABAergic fibers in the medial septal/diagonal band of Broca (MS/DB) area project to the hippocampus and constitute the septo-hippocampal pathway, which has been proven in learning and memory. In addition, the hippocampus has bidirectional connections with the septum, which use this relation for self-regulation of cholinergic input. The activity of septal and hippocampal neurons is modulated by several neurotransmitters including glutamatergic neurons from the entorhinal cortex, serotonergic fibers from the raphe nucleus, dopaminergic neurons from the ventral tegmental area (VTA), histaminergic cells from the tuberomammillary nucleus and adrenergic fibers from the locus coeruleus (LC). Thus, changes in the glutamatergic, serotonergic and etc. mediated transmission in the MS/DB may influence cholinergic or GABAergic transmission in the hippocampus. |
| first_indexed | 2024-03-07T16:48:48Z |
| format | Article |
| id | doaj.art-0fef1b8cb35e44b7af27b7b468c22c62 |
| institution | Directory Open Access Journal |
| issn | 2008-126X 2228-7442 |
| language | English |
| last_indexed | 2024-03-07T16:48:48Z |
| publishDate | 2013-01-01 |
| publisher | Iran University of Medical Sciences |
| record_format | Article |
| series | Basic and Clinical Neuroscience |
| spelling | doaj.art-0fef1b8cb35e44b7af27b7b468c22c622024-03-03T05:36:28ZengIran University of Medical SciencesBasic and Clinical Neuroscience2008-126X2228-74422013-01-014134Septo-Hippocampo-Septal Loop and Memory FormationFatemeh KhakpaiMohammad NasehiAli Haeri-RohaniAkram EidiMohammad Reza ZarrindastCholinergic and GABAergic fibers in the medial septal/diagonal band of Broca (MS/DB) area project to the hippocampus and constitute the septo-hippocampal pathway, which has been proven in learning and memory. In addition, the hippocampus has bidirectional connections with the septum, which use this relation for self-regulation of cholinergic input. The activity of septal and hippocampal neurons is modulated by several neurotransmitters including glutamatergic neurons from the entorhinal cortex, serotonergic fibers from the raphe nucleus, dopaminergic neurons from the ventral tegmental area (VTA), histaminergic cells from the tuberomammillary nucleus and adrenergic fibers from the locus coeruleus (LC). Thus, changes in the glutamatergic, serotonergic and etc. mediated transmission in the MS/DB may influence cholinergic or GABAergic transmission in the hippocampus.http://bcn.tums.ac.ir/browse.php?a_code=A-10-1-135&slc_lang=en&sid=1septo-hippocampalseptumhippocampuslearningmemory |
| spellingShingle | Fatemeh Khakpai Mohammad Nasehi Ali Haeri-Rohani Akram Eidi Mohammad Reza Zarrindast Septo-Hippocampo-Septal Loop and Memory Formation Basic and Clinical Neuroscience septo-hippocampal septum hippocampus learning memory |
| title | Septo-Hippocampo-Septal Loop and Memory Formation |
| title_full | Septo-Hippocampo-Septal Loop and Memory Formation |
| title_fullStr | Septo-Hippocampo-Septal Loop and Memory Formation |
| title_full_unstemmed | Septo-Hippocampo-Septal Loop and Memory Formation |
| title_short | Septo-Hippocampo-Septal Loop and Memory Formation |
| title_sort | septo hippocampo septal loop and memory formation |
| topic | septo-hippocampal septum hippocampus learning memory |
| url | http://bcn.tums.ac.ir/browse.php?a_code=A-10-1-135&slc_lang=en&sid=1 |
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