Maternal body mass index and risk of neonatal adverse outcomes in China: a systematic review and meta-analysis
Abstract Background Maternal body mass index is linked to short- and long-term unfavorable health outcomes both for child and mother. We conducted a systematic review and meta-analysis of population-based cohort studies to evaluate maternal BMI and the risk of harmful neonatal outcomes in China. Met...
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| Format: | Article |
| Language: | English |
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BMC
2019-03-01
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| Series: | BMC Pregnancy and Childbirth |
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| Online Access: | http://link.springer.com/article/10.1186/s12884-019-2249-z |
| _version_ | 1828369606092259328 |
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| author | Lei Liu Yanan Ma Ningning Wang Wenjing Lin Yang Liu Deliang Wen |
| author_facet | Lei Liu Yanan Ma Ningning Wang Wenjing Lin Yang Liu Deliang Wen |
| author_sort | Lei Liu |
| collection | DOAJ |
| description | Abstract Background Maternal body mass index is linked to short- and long-term unfavorable health outcomes both for child and mother. We conducted a systematic review and meta-analysis of population-based cohort studies to evaluate maternal BMI and the risk of harmful neonatal outcomes in China. Methods Six databases identified 2454 articles; 46 met the inclusion criteria for this study. The dichotomous data on maternal BMI and harmful neonatal outcomes were extracted. Pooled statistics (odds ratios, ORs) were derived from Stata/SE, ver. 12.0. Sensitivity analyses assessed the robustness of the results. Meta-regression and subgroup meta-analyses explored heterogeneity. Results The meta-analysis revealed that compared with normal BMI, high maternal BMI is associated with fetal overgrowth, defined as macrosomia ≥4000 g (OR 1.91, 95% CI 1.75–2.09); birth weight ≥ 90% for gestational age (OR 1.88, 95% CI 1.64–2.15); and increased risk of premature birth (OR 1.38, 95% CI 1.25–2.52) and neonatal asphyxia (OR 1.74, 95% CI 1.39–2.17). Maternal underweight increased the risk of low birth weight (OR 1.61, 95% CI 1.33–1.93) and small for gestational age (OR 1.75, 95% CI 1.51–2.02). Conclusions Raised as well as low pre-pregnancy BMI is associated with adverse neonatal outcomes. Management of weight during pregnancy might help reduce their adverse neonatal outcomes in future intervention studies or programmes. |
| first_indexed | 2024-04-14T06:26:51Z |
| format | Article |
| id | doaj.art-0fef9a8df44d4ccfb434a41d67135619 |
| institution | Directory Open Access Journal |
| issn | 1471-2393 |
| language | English |
| last_indexed | 2024-04-14T06:26:51Z |
| publishDate | 2019-03-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pregnancy and Childbirth |
| spelling | doaj.art-0fef9a8df44d4ccfb434a41d671356192022-12-22T02:07:46ZengBMCBMC Pregnancy and Childbirth1471-23932019-03-0119111210.1186/s12884-019-2249-zMaternal body mass index and risk of neonatal adverse outcomes in China: a systematic review and meta-analysisLei Liu0Yanan Ma1Ningning Wang2Wenjing Lin3Yang Liu4Deliang Wen5School of Public Health, Dalian Medical UniversitySchool of Public Health, China Medical UniversitySchool of Public Health, Dalian Medical UniversitySchool of Public Health, Dalian Medical UniversitySchool of Public Health, China Medical UniversitySchool of Public Health, China Medical UniversityAbstract Background Maternal body mass index is linked to short- and long-term unfavorable health outcomes both for child and mother. We conducted a systematic review and meta-analysis of population-based cohort studies to evaluate maternal BMI and the risk of harmful neonatal outcomes in China. Methods Six databases identified 2454 articles; 46 met the inclusion criteria for this study. The dichotomous data on maternal BMI and harmful neonatal outcomes were extracted. Pooled statistics (odds ratios, ORs) were derived from Stata/SE, ver. 12.0. Sensitivity analyses assessed the robustness of the results. Meta-regression and subgroup meta-analyses explored heterogeneity. Results The meta-analysis revealed that compared with normal BMI, high maternal BMI is associated with fetal overgrowth, defined as macrosomia ≥4000 g (OR 1.91, 95% CI 1.75–2.09); birth weight ≥ 90% for gestational age (OR 1.88, 95% CI 1.64–2.15); and increased risk of premature birth (OR 1.38, 95% CI 1.25–2.52) and neonatal asphyxia (OR 1.74, 95% CI 1.39–2.17). Maternal underweight increased the risk of low birth weight (OR 1.61, 95% CI 1.33–1.93) and small for gestational age (OR 1.75, 95% CI 1.51–2.02). Conclusions Raised as well as low pre-pregnancy BMI is associated with adverse neonatal outcomes. Management of weight during pregnancy might help reduce their adverse neonatal outcomes in future intervention studies or programmes.http://link.springer.com/article/10.1186/s12884-019-2249-zMaternal BMIMeta-analysisCohort studyNeonatal outcomes |
| spellingShingle | Lei Liu Yanan Ma Ningning Wang Wenjing Lin Yang Liu Deliang Wen Maternal body mass index and risk of neonatal adverse outcomes in China: a systematic review and meta-analysis BMC Pregnancy and Childbirth Maternal BMI Meta-analysis Cohort study Neonatal outcomes |
| title | Maternal body mass index and risk of neonatal adverse outcomes in China: a systematic review and meta-analysis |
| title_full | Maternal body mass index and risk of neonatal adverse outcomes in China: a systematic review and meta-analysis |
| title_fullStr | Maternal body mass index and risk of neonatal adverse outcomes in China: a systematic review and meta-analysis |
| title_full_unstemmed | Maternal body mass index and risk of neonatal adverse outcomes in China: a systematic review and meta-analysis |
| title_short | Maternal body mass index and risk of neonatal adverse outcomes in China: a systematic review and meta-analysis |
| title_sort | maternal body mass index and risk of neonatal adverse outcomes in china a systematic review and meta analysis |
| topic | Maternal BMI Meta-analysis Cohort study Neonatal outcomes |
| url | http://link.springer.com/article/10.1186/s12884-019-2249-z |
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