Targeting DNA2 overcomes metabolic reprogramming in multiple myeloma

Targeting DNA2 overcomes metabolic reprogramming in multiple myeloma

Abstract DNA damage resistance is a major barrier to effective DNA-damaging therapy in multiple myeloma (MM). To discover mechanisms through which MM cells overcome DNA damage, we investigate how MM cells become resistant to antisense oligonucleotide (ASO) therapy targeting Interleukin enhancer bind...

Full description

Bibliographic Details
Main Authors:	Natthakan Thongon, Feiyang Ma, Natalia Baran, Pamela Lockyer, Jintan Liu, Christopher Jackson, Ashley Rose, Ken Furudate, Bethany Wildeman, Matteo Marchesini, Valentina Marchica, Paola Storti, Giannalisa Todaro, Irene Ganan-Gomez, Vera Adema, Juan Jose Rodriguez-Sevilla, Yun Qing, Min Jin Ha, Rodrigo Fonseca, Caleb Stein, Caleb Class, Lin Tan, Sergio Attanasio, Guillermo Garcia-Manero, Nicola Giuliani, David Berrios Nolasco, Andrea Santoni, Claudio Cerchione, Carlos Bueso-Ramos, Marina Konopleva, Philip Lorenzi, Koichi Takahashi, Elisabet Manasanch, Gabriella Sammarelli, Rashmi Kanagal-Shamanna, Andrea Viale, Marta Chesi, Simona Colla
Format:	Article
Language:	English
Published:	Nature Portfolio 2024-02-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-024-45350-8

Similar Items

S185: TARGETING DNA2 OVERCOMES METABOLIC REPROGRAMMING IN 1Q21 MULTIPLE MYELOMA
by: Natthakan Thongon, et al.
Published: (2023-08-01)

Role of 1q21 in Multiple Myeloma: From Pathogenesis to Possible Therapeutic Targets
by: Jessica Burroughs Garcìa, et al.
Published: (2021-06-01)

Application of Next-Generation Sequencing for the Genomic Characterization of Patients with Smoldering Myeloma
by: Martina Manzoni, et al.
Published: (2020-05-01)

Hematopoietic stem cells with granulo-monocytic differentiation state overcome venetoclax sensitivity in patients with myelodysplastic syndromes
by: Juan Jose Rodriguez-Sevilla, et al.
Published: (2024-03-01)

Hematopoiesis under telomere attrition at the single-cell resolution
by: Natthakan Thongon, et al.
Published: (2021-11-01)

P830: IDENTIFICATION OF NOVEL TARGET GENES CORRELATED WITH 1Q21 AMPLIFICATION IN PATIENTS WITH SMOLDERING MYELOMA AND MULTIPLE MYELOMA
by: Nicolas Thomas Iannozzi, et al.
Published: (2023-08-01)

S160: MOLECULAR DETERMINANTS OF DISEASE PROGRESSION AFTER HYPOMETHYLATING AGENT THERAPY IN RAS PATHWAY MUTANT CHRONIC MYELOMONOCYTIC LEUKEMIA AT THE SINGLE-CELL LEVEL
by: G. Montalban-Bravo, et al.
Published: (2022-06-01)

Predicting organosulfur chemistry in fuel sources
by: Class, Caleb Andrew
Published: (2015)

Biomarkers in Acute Myeloid Leukemia: Leveraging Next Generation Sequencing Data for Optimal Therapeutic Strategies
by: Hanadi El Achi, et al.
Published: (2021-09-01)

Role of Galectins in Multiple Myeloma
by: Paola Storti, et al.
Published: (2017-12-01)

P58 LOW CD38 EXPRESSION BY PLASMA CELLS IN EXTRAMEDULLARY DISEASE IN MULTIPLE MYELOMA PATIENTS
by: L. Notarfranchi, et al.
Published: (2023-05-01)

A kinetic and thermochemical database for organic sulfur and oxygen compounds
by: Class, Caleb A., et al.
Published: (2016)

Automatic mechanism generation for pyrolysis of di-tert-butyl sulfide
by: Class, Caleb Andrew, et al.
Published: (2017)

P754: INITIAL RESULTS OF PHASE I/II STUDY OF AZACITIDINE IN COMBINATION WITH QUIZARTINIB FOR PATIENTS WITH MYELODYSPLASTIC SYNDROME AND MYELODYSPLASTIC/MYELOPROLIFERATIVE NEOPLASM WITH FLT3 OR CBL MUTATION
by: T. Abuasab, et al.
Published: (2022-06-01)

PD-L1/PD-1 Axis in Multiple Myeloma Microenvironment and a Possible Link with CD38-Mediated Immune-Suppression
by: Federica Costa, et al.
Published: (2021-01-01)

Nucleophosmin 1 Mutations in Acute Myeloid Leukemia
by: Jabra Zarka, et al.
Published: (2020-06-01)

Respiratory Muscles Exercise in Chest Physical Therapy
by: Natthakan Leelarungrayub
Published: (2015-02-01)

Chest Physical Therapy Techniques
by: Natthakan Leelarungrayub
Published: (2015-02-01)

PD-L1/PD-1 Pattern of Expression Within the Bone Marrow Immune Microenvironment in Smoldering Myeloma and Active Multiple Myeloma Patients
by: Federica Costa, et al.
Published: (2021-01-01)

Consolidative opacity in a patient with acute leukemia
by: Chaitra Banala, et al.
Published: (2022-04-01)

Detailed kinetic model for hexyl sulfide pyrolysis and its desulfurization by supercritical water
by: Class, Caleb A, et al.
Published: (2021)

Immune response to SARS-CoV-2 mRNA vaccination and booster dose in patients with multiple myeloma and monoclonal gammopathies: impact of Omicron variant on the humoral response
by: Paola Storti, et al.
Published: (2022-12-01)

Thermal energy grid storage : liquid containment and pumping
by: Amy, Caleb(Caleb A.)
Published: (2021)

Does MacIntyre's Moral Sociology Presuppose a Personalist Moral Psychology? MacIntyre and Tomasello on Moral Psychology
by: Caleb Bernacchio, et al.
Published: (2022-02-01)

P743: CLINICAL OUTCOMES OF PATIENTS WITH MYELODYSPLASTIC SYNDROME AND SPLICEOSOME MUTATIONS
by: Samuel Urrutia, et al.
Published: (2023-08-01)

CAD204520 Targets <i>NOTCH1</i> PEST Domain Mutations in Lymphoproliferative Disorders
by: Luca Pagliaro, et al.
Published: (2024-01-01)

Fibroblast growth factor‐23 and parathyroid hormone suppress small intestinal magnesium absorption
by: Nasisorn Suksridechacin, et al.
Published: (2022-04-01)

Mass spectrometric analysis of TRPM6 and TRPM7 from small intestine of omeprazole-induced hypomagnesemic rats
by: Nattida Kampuang, et al.
Published: (2022-08-01)

Detailed kinetic model for hexyl sulfide pyrolysis and its desulfurization by supercritical water
by: Class, Caleb A., et al.
Published: (2022)

The incorporation of health concerns into African river basin planning : a case study based on the Sénégal River basin
by: King, Caleb K. (Caleb Kimball)
Published: (2005)

Application of ion electrospray propulsion to lunar and interplanetary missions
by: Whitlock, Caleb W. (Caleb Wade)
Published: (2014)

Detecting hazardous intensive care patient episodes using real-time mortality models
by: Hug, Caleb W. (Caleb Wayne)
Published: (2010)

Predicting the risk and trajectory of intensive care patients using survival models
by: Hug, Caleb W. (Caleb Wayne)
Published: (2007)

Molecular Features of the Mesenchymal and Osteoblastic Cells in Multiple Myeloma
by: Nicolas Thomas Iannozzi, et al.
Published: (2022-12-01)

A New Approach of Respiratory Physical Therapy in a Patient with Empyema Thoracis after Decortication
by: Natthakan Leelarungrayub, et al.
Published: (2015-02-01)

Supercritical Water Treatment of Crude Oil and Hexylbenzene: An Experimental and Mechanistic Study on Alkylbenzene Decomposition
by: Carr, Adam G., et al.
Published: (2016)

The use of a plant capacity model for production scheduling and operations analysis
by: Dailey, Caleb A. (Caleb Alexander), 1971-
Published: (2010)

Evolutionary action score identifies a subset of TP53 mutated myelodysplastic syndrome with favorable prognosis
by: Rashmi Kanagal-Shamanna, et al.
Published: (2021-03-01)

Metabolic features of myeloma cells in the context of bone microenvironment: Implication for the pathophysiology and clinic of myeloma bone disease
by: Vincenzo Raimondi, et al.
Published: (2022-10-01)

P583: Clinical utility of optical genome mapping as an additional test to standard cytogenetic workup of hematological malignancies
by: Gokce Toruner, et al.
Published: (2024-01-01)