Sex specific differences in hepatic and plasma lipid profiles in healthy cats pre and post spaying and neutering: relationship with feline hepatic lipidosis
Abstract Background A link between lipid metabolism and disease has been recognized in cats. Since hepatic lipidosis is a frequent disorder in cats, the aim of the current study was to evaluate liver and plasma lipid dimorphism in healthy cats and the effects of gonadectomy on lipid profiling. From...
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| Language: | English |
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BMC
2017-08-01
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| Series: | BMC Veterinary Research |
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| Online Access: | http://link.springer.com/article/10.1186/s12917-017-1152-y |
| _version_ | 1819157172826669056 |
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| author | Chiara Valtolina Arie B. Vaandrager Robert P. Favier Maidina Tuohetahuntila Anne Kummeling Isabelle Jeusette Jan Rothuizen Joris H. Robben |
| author_facet | Chiara Valtolina Arie B. Vaandrager Robert P. Favier Maidina Tuohetahuntila Anne Kummeling Isabelle Jeusette Jan Rothuizen Joris H. Robben |
| author_sort | Chiara Valtolina |
| collection | DOAJ |
| description | Abstract Background A link between lipid metabolism and disease has been recognized in cats. Since hepatic lipidosis is a frequent disorder in cats, the aim of the current study was to evaluate liver and plasma lipid dimorphism in healthy cats and the effects of gonadectomy on lipid profiling. From six female and six male cats plasma and liver lipid profiles before and after spaying/neutering were assessed and compared to five cats (three neutered male and two spayed female) diagnosed with hepatic lipidosis. Results Intact female cats had a significantly lower level of plasma triacylglycerides (TAG) and a higher liver level of the long chain polyunsaturated fatty acid arachidonic acid (AA) compared to their neutered state. Both male and female cats with lipidosis had a higher liver, but not plasma TAG level and an increased level of plasma and liver sphingomyelin compared to the healthy cats. Conclusion Although lipid dimorphism in healthy cats resembles that of other species, intact female cats show differences in metabolic configuration that could predispose them to develop hepatic lipidosis. The increased sphingomyelin levels in cats with lipidosis could suggest a potential role in the pathogenesis of hepatic lipidosis in cats. |
| first_indexed | 2024-12-22T16:04:33Z |
| format | Article |
| id | doaj.art-0ff357aca8bb476eae48394713a7a191 |
| institution | Directory Open Access Journal |
| issn | 1746-6148 |
| language | English |
| last_indexed | 2024-12-22T16:04:33Z |
| publishDate | 2017-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Veterinary Research |
| spelling | doaj.art-0ff357aca8bb476eae48394713a7a1912022-12-21T18:20:37ZengBMCBMC Veterinary Research1746-61482017-08-011311910.1186/s12917-017-1152-ySex specific differences in hepatic and plasma lipid profiles in healthy cats pre and post spaying and neutering: relationship with feline hepatic lipidosisChiara Valtolina0Arie B. Vaandrager1Robert P. Favier2Maidina Tuohetahuntila3Anne Kummeling4Isabelle Jeusette5Jan Rothuizen6Joris H. Robben7Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht UniversityDepartment of Biochemistry and Cell Biology, Faculty of Veterinary Medicine and Institute of Biomembranes, Utrecht UniversityDepartment of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht UniversityDepartment of Biochemistry and Cell Biology, Faculty of Veterinary Medicine and Institute of Biomembranes, Utrecht UniversityDepartment of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht UniversityResearch and Development, Affinity Petcare, Pl. Xavier Cugat, 2 Edificio D, 3ª, PlantaDepartment of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht UniversityDepartment of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht UniversityAbstract Background A link between lipid metabolism and disease has been recognized in cats. Since hepatic lipidosis is a frequent disorder in cats, the aim of the current study was to evaluate liver and plasma lipid dimorphism in healthy cats and the effects of gonadectomy on lipid profiling. From six female and six male cats plasma and liver lipid profiles before and after spaying/neutering were assessed and compared to five cats (three neutered male and two spayed female) diagnosed with hepatic lipidosis. Results Intact female cats had a significantly lower level of plasma triacylglycerides (TAG) and a higher liver level of the long chain polyunsaturated fatty acid arachidonic acid (AA) compared to their neutered state. Both male and female cats with lipidosis had a higher liver, but not plasma TAG level and an increased level of plasma and liver sphingomyelin compared to the healthy cats. Conclusion Although lipid dimorphism in healthy cats resembles that of other species, intact female cats show differences in metabolic configuration that could predispose them to develop hepatic lipidosis. The increased sphingomyelin levels in cats with lipidosis could suggest a potential role in the pathogenesis of hepatic lipidosis in cats.http://link.springer.com/article/10.1186/s12917-017-1152-yLipid dimorphismCatsFeline hepatic lipidosisSex hormonesSphingomyelin |
| spellingShingle | Chiara Valtolina Arie B. Vaandrager Robert P. Favier Maidina Tuohetahuntila Anne Kummeling Isabelle Jeusette Jan Rothuizen Joris H. Robben Sex specific differences in hepatic and plasma lipid profiles in healthy cats pre and post spaying and neutering: relationship with feline hepatic lipidosis BMC Veterinary Research Lipid dimorphism Cats Feline hepatic lipidosis Sex hormones Sphingomyelin |
| title | Sex specific differences in hepatic and plasma lipid profiles in healthy cats pre and post spaying and neutering: relationship with feline hepatic lipidosis |
| title_full | Sex specific differences in hepatic and plasma lipid profiles in healthy cats pre and post spaying and neutering: relationship with feline hepatic lipidosis |
| title_fullStr | Sex specific differences in hepatic and plasma lipid profiles in healthy cats pre and post spaying and neutering: relationship with feline hepatic lipidosis |
| title_full_unstemmed | Sex specific differences in hepatic and plasma lipid profiles in healthy cats pre and post spaying and neutering: relationship with feline hepatic lipidosis |
| title_short | Sex specific differences in hepatic and plasma lipid profiles in healthy cats pre and post spaying and neutering: relationship with feline hepatic lipidosis |
| title_sort | sex specific differences in hepatic and plasma lipid profiles in healthy cats pre and post spaying and neutering relationship with feline hepatic lipidosis |
| topic | Lipid dimorphism Cats Feline hepatic lipidosis Sex hormones Sphingomyelin |
| url | http://link.springer.com/article/10.1186/s12917-017-1152-y |
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