Simulating the progression of brain structural alterations in Parkinson’s disease
Abstract Considering brain structural alterations as neurodegenerative consequences of Parkinson's disease (PD), we sought to infer the progression of PD via the ordering of brain structural alterations from cross-sectional MRI observations. Having measured cortical thinning in gray matter (GM)...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-06-01
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| Series: | npj Parkinson's Disease |
| Online Access: | https://doi.org/10.1038/s41531-022-00349-0 |
| _version_ | 1827775355114487808 |
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| author | Chang-hyun Park Na-Young Shin Sang-Won Yoo Haeseok Seo Uicheul Yoon Ji-Yeon Yoo Kookjin Ahn Joong-Seok Kim |
| author_facet | Chang-hyun Park Na-Young Shin Sang-Won Yoo Haeseok Seo Uicheul Yoon Ji-Yeon Yoo Kookjin Ahn Joong-Seok Kim |
| author_sort | Chang-hyun Park |
| collection | DOAJ |
| description | Abstract Considering brain structural alterations as neurodegenerative consequences of Parkinson's disease (PD), we sought to infer the progression of PD via the ordering of brain structural alterations from cross-sectional MRI observations. Having measured cortical thinning in gray matter (GM) regions and disintegrity in white matter (WM) regions as MRI markers of structural alterations for 130 patients with PD (69 ± 10 years, 72 men), stochastic simulation based on the probabilistic relationship between the brain regions was conducted to infer the ordering of structural alterations across all brain regions and the staging of structural alterations according to changes in clinical status. The ordering of structural alterations represented WM disintegrity tending to occur earlier than cortical thinning. The staging of structural alterations indicated structural alterations happening mostly before major disease complications such as postural instability and dementia. Later disease states predicted by the sequence of structural alterations were significantly related to more severe clinical symptoms. The relevance of the ordering of brain structural alterations to the severity of clinical symptoms suggests the clinical feasibility of predicting PD progression states. |
| first_indexed | 2024-03-11T13:48:52Z |
| format | Article |
| id | doaj.art-0ff4996ec5be4b8789bddcc9d55a6697 |
| institution | Directory Open Access Journal |
| issn | 2373-8057 |
| language | English |
| last_indexed | 2024-03-11T13:48:52Z |
| publishDate | 2022-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Parkinson's Disease |
| spelling | doaj.art-0ff4996ec5be4b8789bddcc9d55a66972023-11-02T09:24:23ZengNature Portfolionpj Parkinson's Disease2373-80572022-06-01811810.1038/s41531-022-00349-0Simulating the progression of brain structural alterations in Parkinson’s diseaseChang-hyun Park0Na-Young Shin1Sang-Won Yoo2Haeseok Seo3Uicheul Yoon4Ji-Yeon Yoo5Kookjin Ahn6Joong-Seok Kim7Department of Radiology, College of Medicine, Catholic University of KoreaDepartment of Radiology, College of Medicine, Catholic University of KoreaDepartment of Neurology, College of Medicine, Catholic University of KoreaDepartment of Biomedical Engineering, College of Bio and Medical Sciences, Daegu Catholic UniversityDepartment of Biomedical Engineering, College of Bio and Medical Sciences, Daegu Catholic UniversityDepartment of Neurology, College of Medicine, Catholic University of KoreaDepartment of Radiology, College of Medicine, Catholic University of KoreaDepartment of Neurology, College of Medicine, Catholic University of KoreaAbstract Considering brain structural alterations as neurodegenerative consequences of Parkinson's disease (PD), we sought to infer the progression of PD via the ordering of brain structural alterations from cross-sectional MRI observations. Having measured cortical thinning in gray matter (GM) regions and disintegrity in white matter (WM) regions as MRI markers of structural alterations for 130 patients with PD (69 ± 10 years, 72 men), stochastic simulation based on the probabilistic relationship between the brain regions was conducted to infer the ordering of structural alterations across all brain regions and the staging of structural alterations according to changes in clinical status. The ordering of structural alterations represented WM disintegrity tending to occur earlier than cortical thinning. The staging of structural alterations indicated structural alterations happening mostly before major disease complications such as postural instability and dementia. Later disease states predicted by the sequence of structural alterations were significantly related to more severe clinical symptoms. The relevance of the ordering of brain structural alterations to the severity of clinical symptoms suggests the clinical feasibility of predicting PD progression states.https://doi.org/10.1038/s41531-022-00349-0 |
| spellingShingle | Chang-hyun Park Na-Young Shin Sang-Won Yoo Haeseok Seo Uicheul Yoon Ji-Yeon Yoo Kookjin Ahn Joong-Seok Kim Simulating the progression of brain structural alterations in Parkinson’s disease npj Parkinson's Disease |
| title | Simulating the progression of brain structural alterations in Parkinson’s disease |
| title_full | Simulating the progression of brain structural alterations in Parkinson’s disease |
| title_fullStr | Simulating the progression of brain structural alterations in Parkinson’s disease |
| title_full_unstemmed | Simulating the progression of brain structural alterations in Parkinson’s disease |
| title_short | Simulating the progression of brain structural alterations in Parkinson’s disease |
| title_sort | simulating the progression of brain structural alterations in parkinson s disease |
| url | https://doi.org/10.1038/s41531-022-00349-0 |
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