Current developments on polyhydroxyalkanoates synthesis by using halophiles as a promising cell factory
Abstract Plastic pollution is a severe threat to our environment which necessitates implementation of bioplastics to realize sustainable development for a green world. Polyhydroxyalkanoates (PHA) represent one of the potential candidates for these bioplastics. However, a major challenge faced by PHA...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2020-04-01
|
| Series: | Microbial Cell Factories |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12934-020-01342-z |
| _version_ | 1818458016658227200 |
|---|---|
| author | Ruchira Mitra Tong Xu Hua Xiang Jing Han |
| author_facet | Ruchira Mitra Tong Xu Hua Xiang Jing Han |
| author_sort | Ruchira Mitra |
| collection | DOAJ |
| description | Abstract Plastic pollution is a severe threat to our environment which necessitates implementation of bioplastics to realize sustainable development for a green world. Polyhydroxyalkanoates (PHA) represent one of the potential candidates for these bioplastics. However, a major challenge faced by PHA is the high production cost which limits its commercial application. Halophiles are considered to be a promising cell factory for PHA synthesis due to its several unique characteristics including high salinity requirement preventing microbial contamination, high intracellular osmotic pressure allowing easy cell lysis for PHA recovery, and capability to utilize wide spectrum of low-cost substrates. Optimization of fermentation parameters has made it plausible to achieve large-scale production at low cost by using halophiles. Further deeper insights into halophiles have revealed the existence of diversified and even novel PHA synthetic pathways within different halophilic species that greatly affects PHA type. Thus, precise metabolic engineering of halophiles with the help of advanced tools and strategies have led to more efficient microbial cell factory for PHA production. This review is an endeavour to summarize the various research achievements in these areas which will help the readers to understand the current developments as well as the future efforts in PHA research. |
| first_indexed | 2024-12-14T22:51:45Z |
| format | Article |
| id | doaj.art-0ff65dc1e5d7419cacb3aef8d3532078 |
| institution | Directory Open Access Journal |
| issn | 1475-2859 |
| language | English |
| last_indexed | 2024-12-14T22:51:45Z |
| publishDate | 2020-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Microbial Cell Factories |
| spelling | doaj.art-0ff65dc1e5d7419cacb3aef8d35320782022-12-21T22:44:42ZengBMCMicrobial Cell Factories1475-28592020-04-0119113010.1186/s12934-020-01342-zCurrent developments on polyhydroxyalkanoates synthesis by using halophiles as a promising cell factoryRuchira Mitra0Tong Xu1Hua Xiang2Jing Han3State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of SciencesState Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of SciencesState Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of SciencesState Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of SciencesAbstract Plastic pollution is a severe threat to our environment which necessitates implementation of bioplastics to realize sustainable development for a green world. Polyhydroxyalkanoates (PHA) represent one of the potential candidates for these bioplastics. However, a major challenge faced by PHA is the high production cost which limits its commercial application. Halophiles are considered to be a promising cell factory for PHA synthesis due to its several unique characteristics including high salinity requirement preventing microbial contamination, high intracellular osmotic pressure allowing easy cell lysis for PHA recovery, and capability to utilize wide spectrum of low-cost substrates. Optimization of fermentation parameters has made it plausible to achieve large-scale production at low cost by using halophiles. Further deeper insights into halophiles have revealed the existence of diversified and even novel PHA synthetic pathways within different halophilic species that greatly affects PHA type. Thus, precise metabolic engineering of halophiles with the help of advanced tools and strategies have led to more efficient microbial cell factory for PHA production. This review is an endeavour to summarize the various research achievements in these areas which will help the readers to understand the current developments as well as the future efforts in PHA research.http://link.springer.com/article/10.1186/s12934-020-01342-zPolyhydroxyalkanoatesHalophilesProduction improvementCost reductionNovel PHA biosynthesisMetabolic engineering |
| spellingShingle | Ruchira Mitra Tong Xu Hua Xiang Jing Han Current developments on polyhydroxyalkanoates synthesis by using halophiles as a promising cell factory Microbial Cell Factories Polyhydroxyalkanoates Halophiles Production improvement Cost reduction Novel PHA biosynthesis Metabolic engineering |
| title | Current developments on polyhydroxyalkanoates synthesis by using halophiles as a promising cell factory |
| title_full | Current developments on polyhydroxyalkanoates synthesis by using halophiles as a promising cell factory |
| title_fullStr | Current developments on polyhydroxyalkanoates synthesis by using halophiles as a promising cell factory |
| title_full_unstemmed | Current developments on polyhydroxyalkanoates synthesis by using halophiles as a promising cell factory |
| title_short | Current developments on polyhydroxyalkanoates synthesis by using halophiles as a promising cell factory |
| title_sort | current developments on polyhydroxyalkanoates synthesis by using halophiles as a promising cell factory |
| topic | Polyhydroxyalkanoates Halophiles Production improvement Cost reduction Novel PHA biosynthesis Metabolic engineering |
| url | http://link.springer.com/article/10.1186/s12934-020-01342-z |
| work_keys_str_mv | AT ruchiramitra currentdevelopmentsonpolyhydroxyalkanoatessynthesisbyusinghalophilesasapromisingcellfactory AT tongxu currentdevelopmentsonpolyhydroxyalkanoatessynthesisbyusinghalophilesasapromisingcellfactory AT huaxiang currentdevelopmentsonpolyhydroxyalkanoatessynthesisbyusinghalophilesasapromisingcellfactory AT jinghan currentdevelopmentsonpolyhydroxyalkanoatessynthesisbyusinghalophilesasapromisingcellfactory |