The Role and Regulatory Network of the CiaRH Two-Component System in Streptococcal Species
Pathogenic streptococcal species are responsible for a broad spectrum of human diseases ranging from non-invasive and localized infections to more aggressive and life-threatening diseases, which cause great economic losses worldwide. Streptococci possess a dozen two-component systems (TCSs) that pla...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-07-01
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| Series: | Frontiers in Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2021.693858/full |
| _version_ | 1819095511656824832 |
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| author | Li-Yuan He Yao-Jin Le Zhong Guo Sha Li Xiao-Yan Yang |
| author_facet | Li-Yuan He Yao-Jin Le Zhong Guo Sha Li Xiao-Yan Yang |
| author_sort | Li-Yuan He |
| collection | DOAJ |
| description | Pathogenic streptococcal species are responsible for a broad spectrum of human diseases ranging from non-invasive and localized infections to more aggressive and life-threatening diseases, which cause great economic losses worldwide. Streptococci possess a dozen two-component systems (TCSs) that play important roles in the response to different environmental changes and adjust the expression of multiple genes to successfully colonize and infect host cells. In this review, we discuss the progress in the study of a conserved TCS named CiaRH in pathogenic or opportunistic streptococci including Streptococcus pneumoniae, Streptococcus pyogenes, Streptococcus agalactiae, Streptococcus mutans, Streptococcus gordonii, Streptococcus sanguinis, and Streptococcus suis, focusing on the function and regulatory networks of CiaRH, which will provide a promising strategy for the exploration of novel antistreptococcal therapies. This review highlights the important role of CiaRH and provides an important basis for the development of antistreptococcal drugs and vaccines. |
| first_indexed | 2024-12-21T23:44:28Z |
| format | Article |
| id | doaj.art-0ff6a6226020439a9a5340285d2b7786 |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-12-21T23:44:28Z |
| publishDate | 2021-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-0ff6a6226020439a9a5340285d2b77862022-12-21T18:46:09ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2021-07-011210.3389/fmicb.2021.693858693858The Role and Regulatory Network of the CiaRH Two-Component System in Streptococcal SpeciesLi-Yuan He0Yao-Jin Le1Zhong Guo2Sha Li3Xiao-Yan Yang4Zhuhai Key Laboratory of Basic and Applied Research in Chinese Medicine, Department of Bioengineering, Zhuhai Campus of Zunyi Medical University, Zhuhai, ChinaZhuhai Key Laboratory of Basic and Applied Research in Chinese Medicine, Department of Bioengineering, Zhuhai Campus of Zunyi Medical University, Zhuhai, ChinaCenter for Biological Science and Technology, Beijing Normal University, Zhuhai, ChinaZhuhai Key Laboratory of Basic and Applied Research in Chinese Medicine, Department of Bioengineering, Zhuhai Campus of Zunyi Medical University, Zhuhai, ChinaZhuhai Key Laboratory of Basic and Applied Research in Chinese Medicine, Department of Bioengineering, Zhuhai Campus of Zunyi Medical University, Zhuhai, ChinaPathogenic streptococcal species are responsible for a broad spectrum of human diseases ranging from non-invasive and localized infections to more aggressive and life-threatening diseases, which cause great economic losses worldwide. Streptococci possess a dozen two-component systems (TCSs) that play important roles in the response to different environmental changes and adjust the expression of multiple genes to successfully colonize and infect host cells. In this review, we discuss the progress in the study of a conserved TCS named CiaRH in pathogenic or opportunistic streptococci including Streptococcus pneumoniae, Streptococcus pyogenes, Streptococcus agalactiae, Streptococcus mutans, Streptococcus gordonii, Streptococcus sanguinis, and Streptococcus suis, focusing on the function and regulatory networks of CiaRH, which will provide a promising strategy for the exploration of novel antistreptococcal therapies. This review highlights the important role of CiaRH and provides an important basis for the development of antistreptococcal drugs and vaccines.https://www.frontiersin.org/articles/10.3389/fmicb.2021.693858/fulltwo-component system CiaRHhistidine kinase CiaHresponse regulator CiaRstreptococciregulatory network |
| spellingShingle | Li-Yuan He Yao-Jin Le Zhong Guo Sha Li Xiao-Yan Yang The Role and Regulatory Network of the CiaRH Two-Component System in Streptococcal Species Frontiers in Microbiology two-component system CiaRH histidine kinase CiaH response regulator CiaR streptococci regulatory network |
| title | The Role and Regulatory Network of the CiaRH Two-Component System in Streptococcal Species |
| title_full | The Role and Regulatory Network of the CiaRH Two-Component System in Streptococcal Species |
| title_fullStr | The Role and Regulatory Network of the CiaRH Two-Component System in Streptococcal Species |
| title_full_unstemmed | The Role and Regulatory Network of the CiaRH Two-Component System in Streptococcal Species |
| title_short | The Role and Regulatory Network of the CiaRH Two-Component System in Streptococcal Species |
| title_sort | role and regulatory network of the ciarh two component system in streptococcal species |
| topic | two-component system CiaRH histidine kinase CiaH response regulator CiaR streptococci regulatory network |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2021.693858/full |
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