Inhibition of histone methyltransferase PRMT5 attenuates cisplatin-induced hearing loss through the PI3K/Akt-mediated mitochondrial apoptotic pathway

Inhibition of histone methyltransferase PRMT5 attenuates cisplatin-induced hearing loss through the PI3K/Akt-mediated mitochondrial apoptotic pathway

This study aimed to evaluate the therapeutic potential of inhibiting protein arginine methyltransferase 5 (PRMT5) in cisplatin-induced hearing loss. The effects of PRMT5 inhibition on cisplatin-induced auditory injury were determined using immunohistochemistry, apoptosis assays, and auditory brainst...

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Bibliographic Details
Main Authors: Zhiwei Zheng, Benyu Nan, Chang Liu, Dongmei Tang, Wen Li, Liping Zhao, Guohui Nie, Yingzi He
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:Journal of Pharmaceutical Analysis
Subjects:
Protein arginine methyltransferase 5 (PRMT5)
LLY-283
Cisplatin
Hearing loss
Hair cell
Spiral ganglion neuron
Online Access:http://www.sciencedirect.com/science/article/pii/S2095177923000813

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