In Vitro Antimicrobial and Anticancer Peculiarities of Ytterbium and Cerium Co-Doped Zinc Oxide Nanoparticles
Zinc oxide nanoparticles (ZnO NPs) are a promising platform for their use in biomedical research, especially given their anticancer and antimicrobial activities. This work presents the synthesis of ZnO NPs doped with different amounts of rare-earth ions of ytterbium (Yb) and cerium (Ce) and the asse...
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2022-12-01
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| author | Essia Hannachi Firdos Alam Khan Yassine Slimani Suriya Rehman Zayneb Trabelsi Sultan Akhtar Ebtesam A. Al-Suhaimi |
| author_facet | Essia Hannachi Firdos Alam Khan Yassine Slimani Suriya Rehman Zayneb Trabelsi Sultan Akhtar Ebtesam A. Al-Suhaimi |
| author_sort | Essia Hannachi |
| collection | DOAJ |
| description | Zinc oxide nanoparticles (ZnO NPs) are a promising platform for their use in biomedical research, especially given their anticancer and antimicrobial activities. This work presents the synthesis of ZnO NPs doped with different amounts of rare-earth ions of ytterbium (Yb) and cerium (Ce) and the assessment of their anticancer and antimicrobial activities. The structural investigations indicated a hexagonal wurtzite structure for all prepared NPs. The particle size was reduced by raising the amount of Ce and Yb in ZnO. The anticancer capabilities of the samples were examined by the cell viability MTT assay. Post 48-h treatment showed a reduction in the cancer cell viability, which was x = 0.00 (68%), x = 0.01 (58.70%), x = 0.03 (80.94%) and x = 0.05 (64.91%), respectively. We found that samples doped with x = 0.01 and x = 0.05 of Yb and Ce showed a better inhibitory effect on HCT-116 cancer cells than unadded ZnO (x = 0.00). The IC<sub>50</sub> for HCT-116 cells of Ce and Yb co-doped ZnO nanoparticles was calculated and the IC<sub>50</sub> values were x = 0.01 (3.50 µg/mL), x = 0.05 (8.25 µg/mL), x = 0.00 (11.75 µg/mL), and x = 0.03 (21.50 µg/mL). The treatment-doped ZnO NPs caused apoptotic cell death in the HCT-116 cells. The nanoparticles showed inhibitory action on both <i>C. albicans</i> and <i>E. coli</i>. It can be concluded that doping ZnO NPs with Yb and Ce improves their apoptotic effects on cancer and microbial cells. |
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| spelling | doaj.art-0ffa1cfefcde40f9ba9b03e3f3d4601a2023-11-24T13:24:22ZengMDPI AGBiology2079-77372022-12-011112183610.3390/biology11121836In Vitro Antimicrobial and Anticancer Peculiarities of Ytterbium and Cerium Co-Doped Zinc Oxide NanoparticlesEssia Hannachi0Firdos Alam Khan1Yassine Slimani2Suriya Rehman3Zayneb Trabelsi4Sultan Akhtar5Ebtesam A. Al-Suhaimi6Department of Nuclear Medicine Research, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, P.O. Box 1982, Dammam 31441, Saudi ArabiaDepartment of Stem Cell Research, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, P.O. Box 1982, Dammam 31441, Saudi ArabiaDepartment of Biophysics, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, P.O. Box 1982, Dammam 31441, Saudi ArabiaDepartment of Epidemic Diseases Research, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, P.O. Box 1982, Dammam 31441, Saudi ArabiaDepartment of Physics, Faculty of Science of Bizerte, University of Carthage, Bizerte 7021, TunisiaDepartment of Biophysics, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, P.O. Box 1982, Dammam 31441, Saudi ArabiaBiology Department & Institute for Research and Medical Consultations (IRMC), College of Science, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, Dammam 31441, Saudi ArabiaZinc oxide nanoparticles (ZnO NPs) are a promising platform for their use in biomedical research, especially given their anticancer and antimicrobial activities. This work presents the synthesis of ZnO NPs doped with different amounts of rare-earth ions of ytterbium (Yb) and cerium (Ce) and the assessment of their anticancer and antimicrobial activities. The structural investigations indicated a hexagonal wurtzite structure for all prepared NPs. The particle size was reduced by raising the amount of Ce and Yb in ZnO. The anticancer capabilities of the samples were examined by the cell viability MTT assay. Post 48-h treatment showed a reduction in the cancer cell viability, which was x = 0.00 (68%), x = 0.01 (58.70%), x = 0.03 (80.94%) and x = 0.05 (64.91%), respectively. We found that samples doped with x = 0.01 and x = 0.05 of Yb and Ce showed a better inhibitory effect on HCT-116 cancer cells than unadded ZnO (x = 0.00). The IC<sub>50</sub> for HCT-116 cells of Ce and Yb co-doped ZnO nanoparticles was calculated and the IC<sub>50</sub> values were x = 0.01 (3.50 µg/mL), x = 0.05 (8.25 µg/mL), x = 0.00 (11.75 µg/mL), and x = 0.03 (21.50 µg/mL). The treatment-doped ZnO NPs caused apoptotic cell death in the HCT-116 cells. The nanoparticles showed inhibitory action on both <i>C. albicans</i> and <i>E. coli</i>. It can be concluded that doping ZnO NPs with Yb and Ce improves their apoptotic effects on cancer and microbial cells.https://www.mdpi.com/2079-7737/11/12/1836ZnO nanoparticlesrare earthdopingantimicrobial activityanticancer activity |
| spellingShingle | Essia Hannachi Firdos Alam Khan Yassine Slimani Suriya Rehman Zayneb Trabelsi Sultan Akhtar Ebtesam A. Al-Suhaimi In Vitro Antimicrobial and Anticancer Peculiarities of Ytterbium and Cerium Co-Doped Zinc Oxide Nanoparticles Biology ZnO nanoparticles rare earth doping antimicrobial activity anticancer activity |
| title | In Vitro Antimicrobial and Anticancer Peculiarities of Ytterbium and Cerium Co-Doped Zinc Oxide Nanoparticles |
| title_full | In Vitro Antimicrobial and Anticancer Peculiarities of Ytterbium and Cerium Co-Doped Zinc Oxide Nanoparticles |
| title_fullStr | In Vitro Antimicrobial and Anticancer Peculiarities of Ytterbium and Cerium Co-Doped Zinc Oxide Nanoparticles |
| title_full_unstemmed | In Vitro Antimicrobial and Anticancer Peculiarities of Ytterbium and Cerium Co-Doped Zinc Oxide Nanoparticles |
| title_short | In Vitro Antimicrobial and Anticancer Peculiarities of Ytterbium and Cerium Co-Doped Zinc Oxide Nanoparticles |
| title_sort | in vitro antimicrobial and anticancer peculiarities of ytterbium and cerium co doped zinc oxide nanoparticles |
| topic | ZnO nanoparticles rare earth doping antimicrobial activity anticancer activity |
| url | https://www.mdpi.com/2079-7737/11/12/1836 |
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