Effect of high-frequency repetitive transcranial magnetic stimulation under different intensities upon rehabilitation of chronic pelvic pain syndrome: protocol for a randomized controlled trial
Abstract Introduction Nearly one in seven women worldwide suffers from chronic pelvic pain syndrome (CPPS) each year. Often, CPPS necessitates a combination of treatments. Studies have shown the good therapeutic effects of repetitive transcranial magnetic stimulation (rTMS) upon CPPS. We wish to und...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-01-01
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| Series: | Trials |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13063-023-07082-w |
| _version_ | 1797945717190295552 |
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| author | Mengyang Wang Rui Xia Jiao Shi Chunhua Yang Yongqing Zhang Zhengxian Xu Cancan Yu Ziyi Wu Min Wang Shangjie Chen Hongdang Qu |
| author_facet | Mengyang Wang Rui Xia Jiao Shi Chunhua Yang Yongqing Zhang Zhengxian Xu Cancan Yu Ziyi Wu Min Wang Shangjie Chen Hongdang Qu |
| author_sort | Mengyang Wang |
| collection | DOAJ |
| description | Abstract Introduction Nearly one in seven women worldwide suffers from chronic pelvic pain syndrome (CPPS) each year. Often, CPPS necessitates a combination of treatments. Studies have shown the good therapeutic effects of repetitive transcranial magnetic stimulation (rTMS) upon CPPS. We wish to undertake a randomized controlled trial (RCT) to observe the effect of high-frequency rTMS at different intensities upon CPPS. Methods and analyses In this prospective, double-blinded RCT, 63 female CPPS participants will be recruited and randomized (1:1:1) to high-intensity rTMS, low-intensity rTMS, or sham rTMS. The control group will receive a 10-day course of conventional pelvic floor (PF) rehabilitation (neuromuscular stimulation, magnetic therapy, or light therapy of the PF). On the basis of conventional treatment, participants in the high-intensity rTMS group will receive pulses of 10 Hz with a resting motor threshold (RMT) of 110% for a total of 15,000 pulses. Participants in the low-intensity rTMS group will receive pulses of 10 Hz with an RMT of 80% with 15,000 pulses. The sham rTMS group will be subjected to sham stimulation with the same sound as produced by the real magnetic stimulation coil. The primary outcome will be determined using a visual analog scale, the Genitourinary Pain Index, Zung Self-Rating Anxiety Scale, and Zung Self-Rating Depression Scale. The secondary outcome will be determined by electromyography of the surface of PF muscles at baseline and after treatment completion. Ethics and dissemination This study is approved by the Ethics Committee of Bao’an People’s Hospital, Shenzhen, Guangdong Province (approval number: BYL20211203). The results will be submitted for publication in peer-reviewed journals and disseminated at scientific conferences (Protocol version 1.0-20220709). Trial registration Chictr.org.cn, ID: ChiCTR2200055615. Registered on 14 January 2022, http://www.chictr.org.cn/showproj.aspx?proj=146720 . Protocol version 1.0-20220709. |
| first_indexed | 2024-04-10T20:59:31Z |
| format | Article |
| id | doaj.art-0ffb4b6b761842b38ad9d40776db7eff |
| institution | Directory Open Access Journal |
| issn | 1745-6215 |
| language | English |
| last_indexed | 2024-04-10T20:59:31Z |
| publishDate | 2023-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Trials |
| spelling | doaj.art-0ffb4b6b761842b38ad9d40776db7eff2023-01-22T12:24:11ZengBMCTrials1745-62152023-01-0124111010.1186/s13063-023-07082-wEffect of high-frequency repetitive transcranial magnetic stimulation under different intensities upon rehabilitation of chronic pelvic pain syndrome: protocol for a randomized controlled trialMengyang Wang0Rui Xia1Jiao Shi2Chunhua Yang3Yongqing Zhang4Zhengxian Xu5Cancan Yu6Ziyi Wu7Min Wang8Shangjie Chen9Hongdang Qu10The First Affiliated Hospital of Bengbu Medical CollegeSecond Affiliated Hospital of Shenzhen UniversitySecond Affiliated Hospital of Shenzhen UniversityThe First Affiliated Hospital of Bengbu Medical CollegeThe First Affiliated Hospital of Bengbu Medical CollegeThe First Affiliated Hospital of Bengbu Medical CollegeThe First Affiliated Hospital of Bengbu Medical CollegeSecond Affiliated Hospital of Shenzhen UniversityThe First Affiliated Hospital of Bengbu Medical CollegeSecond Affiliated Hospital of Shenzhen UniversityThe First Affiliated Hospital of Bengbu Medical CollegeAbstract Introduction Nearly one in seven women worldwide suffers from chronic pelvic pain syndrome (CPPS) each year. Often, CPPS necessitates a combination of treatments. Studies have shown the good therapeutic effects of repetitive transcranial magnetic stimulation (rTMS) upon CPPS. We wish to undertake a randomized controlled trial (RCT) to observe the effect of high-frequency rTMS at different intensities upon CPPS. Methods and analyses In this prospective, double-blinded RCT, 63 female CPPS participants will be recruited and randomized (1:1:1) to high-intensity rTMS, low-intensity rTMS, or sham rTMS. The control group will receive a 10-day course of conventional pelvic floor (PF) rehabilitation (neuromuscular stimulation, magnetic therapy, or light therapy of the PF). On the basis of conventional treatment, participants in the high-intensity rTMS group will receive pulses of 10 Hz with a resting motor threshold (RMT) of 110% for a total of 15,000 pulses. Participants in the low-intensity rTMS group will receive pulses of 10 Hz with an RMT of 80% with 15,000 pulses. The sham rTMS group will be subjected to sham stimulation with the same sound as produced by the real magnetic stimulation coil. The primary outcome will be determined using a visual analog scale, the Genitourinary Pain Index, Zung Self-Rating Anxiety Scale, and Zung Self-Rating Depression Scale. The secondary outcome will be determined by electromyography of the surface of PF muscles at baseline and after treatment completion. Ethics and dissemination This study is approved by the Ethics Committee of Bao’an People’s Hospital, Shenzhen, Guangdong Province (approval number: BYL20211203). The results will be submitted for publication in peer-reviewed journals and disseminated at scientific conferences (Protocol version 1.0-20220709). Trial registration Chictr.org.cn, ID: ChiCTR2200055615. Registered on 14 January 2022, http://www.chictr.org.cn/showproj.aspx?proj=146720 . Protocol version 1.0-20220709.https://doi.org/10.1186/s13063-023-07082-wrTMSCPPSRandomized controlled trialRCT protocol |
| spellingShingle | Mengyang Wang Rui Xia Jiao Shi Chunhua Yang Yongqing Zhang Zhengxian Xu Cancan Yu Ziyi Wu Min Wang Shangjie Chen Hongdang Qu Effect of high-frequency repetitive transcranial magnetic stimulation under different intensities upon rehabilitation of chronic pelvic pain syndrome: protocol for a randomized controlled trial Trials rTMS CPPS Randomized controlled trial RCT protocol |
| title | Effect of high-frequency repetitive transcranial magnetic stimulation under different intensities upon rehabilitation of chronic pelvic pain syndrome: protocol for a randomized controlled trial |
| title_full | Effect of high-frequency repetitive transcranial magnetic stimulation under different intensities upon rehabilitation of chronic pelvic pain syndrome: protocol for a randomized controlled trial |
| title_fullStr | Effect of high-frequency repetitive transcranial magnetic stimulation under different intensities upon rehabilitation of chronic pelvic pain syndrome: protocol for a randomized controlled trial |
| title_full_unstemmed | Effect of high-frequency repetitive transcranial magnetic stimulation under different intensities upon rehabilitation of chronic pelvic pain syndrome: protocol for a randomized controlled trial |
| title_short | Effect of high-frequency repetitive transcranial magnetic stimulation under different intensities upon rehabilitation of chronic pelvic pain syndrome: protocol for a randomized controlled trial |
| title_sort | effect of high frequency repetitive transcranial magnetic stimulation under different intensities upon rehabilitation of chronic pelvic pain syndrome protocol for a randomized controlled trial |
| topic | rTMS CPPS Randomized controlled trial RCT protocol |
| url | https://doi.org/10.1186/s13063-023-07082-w |
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