Coronaviruses and Central Nervous System Manifestations
SARS-CoV-2 is a highly pathogenic coronavirus that has caused an ongoing worldwide pandemic. Emerging in Wuhan, China in December 2019, the virus has spread rapidly around the world. Corona virus disease 2019 (COVID-19), which is caused by SARS-CoV-2, has resulted in significant morbidity and mortal...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-06-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fneur.2020.00715/full |
| _version_ | 1818878408848834560 |
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| author | Mohamed Khateb Noam Bosak Maryam Muqary |
| author_facet | Mohamed Khateb Noam Bosak Maryam Muqary |
| author_sort | Mohamed Khateb |
| collection | DOAJ |
| description | SARS-CoV-2 is a highly pathogenic coronavirus that has caused an ongoing worldwide pandemic. Emerging in Wuhan, China in December 2019, the virus has spread rapidly around the world. Corona virus disease 2019 (COVID-19), which is caused by SARS-CoV-2, has resulted in significant morbidity and mortality. The most prominent symptoms of SARS-CoV-2 infection are respiratory. However, accumulating evidence highlights involvement of the central nervous system (CNS). This includes headache, anosmia, meningoencephalitis, acute ischemic stroke, and several presumably post/para-infectious syndromes and altered mental status not explained by respiratory etiologies. Interestingly, previous studies in animal models emphasized the neurotropism of coronaviruses; thus, these CNS manifestations of COVID-19 are not surprising. This minireview scans the literature regarding the involvement of the CNS in coronavirus infections in general, and in regard to the recent SARS-CoV-2, specifically. |
| first_indexed | 2024-12-19T14:13:43Z |
| format | Article |
| id | doaj.art-0ffc7187109e49b28856dde994886f8e |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-19T14:13:43Z |
| publishDate | 2020-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-0ffc7187109e49b28856dde994886f8e2022-12-21T20:18:02ZengFrontiers Media S.A.Frontiers in Neurology1664-22952020-06-011110.3389/fneur.2020.00715553242Coronaviruses and Central Nervous System ManifestationsMohamed Khateb0Noam Bosak1Maryam Muqary2Department of Neurology, Rambam Health Care Campus, Haifa, IsraelDepartment of Neurology, Rambam Health Care Campus, Haifa, IsraelDepartment of Psychiatry, Rambam Health Care Campus, Haifa, IsraelSARS-CoV-2 is a highly pathogenic coronavirus that has caused an ongoing worldwide pandemic. Emerging in Wuhan, China in December 2019, the virus has spread rapidly around the world. Corona virus disease 2019 (COVID-19), which is caused by SARS-CoV-2, has resulted in significant morbidity and mortality. The most prominent symptoms of SARS-CoV-2 infection are respiratory. However, accumulating evidence highlights involvement of the central nervous system (CNS). This includes headache, anosmia, meningoencephalitis, acute ischemic stroke, and several presumably post/para-infectious syndromes and altered mental status not explained by respiratory etiologies. Interestingly, previous studies in animal models emphasized the neurotropism of coronaviruses; thus, these CNS manifestations of COVID-19 are not surprising. This minireview scans the literature regarding the involvement of the CNS in coronavirus infections in general, and in regard to the recent SARS-CoV-2, specifically.https://www.frontiersin.org/article/10.3389/fneur.2020.00715/fullSARS-CoV-2coronaviral infectionsCOVID-19neurological & psychiatric symptomsbrain disordersneurological infection and inflammation |
| spellingShingle | Mohamed Khateb Noam Bosak Maryam Muqary Coronaviruses and Central Nervous System Manifestations Frontiers in Neurology SARS-CoV-2 coronaviral infections COVID-19 neurological & psychiatric symptoms brain disorders neurological infection and inflammation |
| title | Coronaviruses and Central Nervous System Manifestations |
| title_full | Coronaviruses and Central Nervous System Manifestations |
| title_fullStr | Coronaviruses and Central Nervous System Manifestations |
| title_full_unstemmed | Coronaviruses and Central Nervous System Manifestations |
| title_short | Coronaviruses and Central Nervous System Manifestations |
| title_sort | coronaviruses and central nervous system manifestations |
| topic | SARS-CoV-2 coronaviral infections COVID-19 neurological & psychiatric symptoms brain disorders neurological infection and inflammation |
| url | https://www.frontiersin.org/article/10.3389/fneur.2020.00715/full |
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