Synergistic inter-clonal cooperation involving crosstalk, co-option and co-dependency can enhance the invasiveness of genetically distant cancer clones

Synergistic inter-clonal cooperation involving crosstalk, co-option and co-dependency can enhance the invasiveness of genetically distant cancer clones

Abstract Background Despite intensive research, cancer remains a major health problem. The difficulties in treating cancer reflect the complex nature of this disease, including high levels of heterogeneity within tumours. Intra-tumour heterogeneity creates the conditions for inter-clonal competition...

Full description

Bibliographic Details
Main Authors: Caroline S. Carneiro, Jorian D. Hapeman, Aurora M. Nedelcu
Format: Article
Language:English
Published: BMC 2023-05-01
Series:BMC Ecology and Evolution
Subjects:
Cooperation
Crosstalk
Co-option
Conditioned media
TGF-β1
Intra-tumour heterogeneity
Online Access:https://doi.org/10.1186/s12862-023-02129-7

Internet

https://doi.org/10.1186/s12862-023-02129-7

Similar Items