Targeting the Limbic System: Insights into Its Involvement in Tinnitus
Tinnitus is originally derived from the Latin verb <i>tinnire</i>, which means “to ring”. Tinnitus, a complex disorder, is a result of sentient cognizance of a sound in the absence of an external auditory stimulus. It is reported in children, adults, and older populations. Patients suffe...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-06-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/12/9889 |
| _version_ | 1797594323544440832 |
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| author | Anurag Singh Paul F. Smith Yiwen Zheng |
| author_facet | Anurag Singh Paul F. Smith Yiwen Zheng |
| author_sort | Anurag Singh |
| collection | DOAJ |
| description | Tinnitus is originally derived from the Latin verb <i>tinnire</i>, which means “to ring”. Tinnitus, a complex disorder, is a result of sentient cognizance of a sound in the absence of an external auditory stimulus. It is reported in children, adults, and older populations. Patients suffering from tinnitus often present with hearing loss, anxiety, depression, and sleep disruption in addition to a hissing and ringing in the ear. Surgical interventions and many other forms of treatment have been only partially effective due to heterogeneity in tinnitus patients and a lack of understanding of the mechanisms of tinnitus. Although researchers across the globe have made significant progress in understanding the underlying mechanisms of tinnitus over the past few decades, tinnitus is still deemed to be a scientific enigma. This review summarises the role of the limbic system in tinnitus development and provides insight into the development of potential target-specific tinnitus therapies. |
| first_indexed | 2024-03-11T02:22:04Z |
| format | Article |
| id | doaj.art-0fffb55084814c6a94a2315b24b42177 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T02:22:04Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-0fffb55084814c6a94a2315b24b421772023-11-18T10:45:32ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-06-012412988910.3390/ijms24129889Targeting the Limbic System: Insights into Its Involvement in TinnitusAnurag Singh0Paul F. Smith1Yiwen Zheng2Department of Pharmacology and Toxicology, School of Biomedical Sciences, University of Otago, Dunedin 9016, New ZealandDepartment of Pharmacology and Toxicology, School of Biomedical Sciences, University of Otago, Dunedin 9016, New ZealandDepartment of Pharmacology and Toxicology, School of Biomedical Sciences, University of Otago, Dunedin 9016, New ZealandTinnitus is originally derived from the Latin verb <i>tinnire</i>, which means “to ring”. Tinnitus, a complex disorder, is a result of sentient cognizance of a sound in the absence of an external auditory stimulus. It is reported in children, adults, and older populations. Patients suffering from tinnitus often present with hearing loss, anxiety, depression, and sleep disruption in addition to a hissing and ringing in the ear. Surgical interventions and many other forms of treatment have been only partially effective due to heterogeneity in tinnitus patients and a lack of understanding of the mechanisms of tinnitus. Although researchers across the globe have made significant progress in understanding the underlying mechanisms of tinnitus over the past few decades, tinnitus is still deemed to be a scientific enigma. This review summarises the role of the limbic system in tinnitus development and provides insight into the development of potential target-specific tinnitus therapies.https://www.mdpi.com/1422-0067/24/12/9889tinnitusauditory systemlimbic systemsynaptic plasticityhippocampusamygdala |
| spellingShingle | Anurag Singh Paul F. Smith Yiwen Zheng Targeting the Limbic System: Insights into Its Involvement in Tinnitus International Journal of Molecular Sciences tinnitus auditory system limbic system synaptic plasticity hippocampus amygdala |
| title | Targeting the Limbic System: Insights into Its Involvement in Tinnitus |
| title_full | Targeting the Limbic System: Insights into Its Involvement in Tinnitus |
| title_fullStr | Targeting the Limbic System: Insights into Its Involvement in Tinnitus |
| title_full_unstemmed | Targeting the Limbic System: Insights into Its Involvement in Tinnitus |
| title_short | Targeting the Limbic System: Insights into Its Involvement in Tinnitus |
| title_sort | targeting the limbic system insights into its involvement in tinnitus |
| topic | tinnitus auditory system limbic system synaptic plasticity hippocampus amygdala |
| url | https://www.mdpi.com/1422-0067/24/12/9889 |
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