Prognosis of thyroid nodules in individuals living in the Zhitomir region of Ukraine.
<h4>Objective</h4>After the accident at the Chernobyl Nuclear Power Plant (CNPP), the incidence of thyroid cancer increased among children. Recently, a strong relationship between solid thyroid nodules and the incidence of thyroid cancer was shown in atomic bomb survivors. To assess the...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2012-01-01
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| Series: | PLoS ONE |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23209797/?tool=EBI |
| _version_ | 1818574575183593472 |
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| author | Naomi Hayashida Yui Sekitani Jumpei Takahashi Alexander A Kozlovsky Oleksandr K Gutevych Aleksey S Saiko Nina V Nirova Anjela A Petrova Ruslan M Rafalskiy Sergey A Chorny Valery V Daniliuk Masanobu Anami Shunichi Yamashita Noboru Takamura |
| author_facet | Naomi Hayashida Yui Sekitani Jumpei Takahashi Alexander A Kozlovsky Oleksandr K Gutevych Aleksey S Saiko Nina V Nirova Anjela A Petrova Ruslan M Rafalskiy Sergey A Chorny Valery V Daniliuk Masanobu Anami Shunichi Yamashita Noboru Takamura |
| author_sort | Naomi Hayashida |
| collection | DOAJ |
| description | <h4>Objective</h4>After the accident at the Chernobyl Nuclear Power Plant (CNPP), the incidence of thyroid cancer increased among children. Recently, a strong relationship between solid thyroid nodules and the incidence of thyroid cancer was shown in atomic bomb survivors. To assess the prognosis of benign thyroid nodules in individuals living in the Zhitomir region of Ukraine, around the CNPP, we conducted a follow-up investigation of screening data from 1991 to 2000 in the Ukraine.<h4>Patients and methods</h4>Participants of this study were 160 inhabitants with thyroid nodules (nodule group) and 160 inhabitants without thyroid nodules (normal control group) intially identified by ultrasonography from 1991 to 2000. All participants were aged 0 to 10 years old and lived in the same area at the time of the accident. We performed follow-up screening of participants and assessed thyroid nodules by fine needle aspiration biopsy.<h4>Results</h4>Among the nodule group participants, the number and size of nodules were significantly increased at the follow-up screening compared with the initial screening. No thyroid nodules were observed among the normal control group participants. The prevalence of thyroid abnormality, especially nodules that could be cancerous (malignant or suspicious by fine needle aspiration biopsy), was 7.5% in the nodule group and 0% in the normal control group (P<0.001).<h4>Conclusions</h4>Our study indicated that a thyroid nodule in childhood is a prognostic factor associated with an increase in the number and size of nodules in individuals living in the Zhitomir region of Ukraine. |
| first_indexed | 2024-12-15T00:28:22Z |
| format | Article |
| id | doaj.art-100377d59100496387db711e298961e6 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-15T00:28:22Z |
| publishDate | 2012-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-100377d59100496387db711e298961e62022-12-21T22:42:05ZengPublic Library of Science (PLoS)PLoS ONE1932-62032012-01-01711e5064810.1371/journal.pone.0050648Prognosis of thyroid nodules in individuals living in the Zhitomir region of Ukraine.Naomi HayashidaYui SekitaniJumpei TakahashiAlexander A KozlovskyOleksandr K GutevychAleksey S SaikoNina V NirovaAnjela A PetrovaRuslan M RafalskiySergey A ChornyValery V DaniliukMasanobu AnamiShunichi YamashitaNoboru Takamura<h4>Objective</h4>After the accident at the Chernobyl Nuclear Power Plant (CNPP), the incidence of thyroid cancer increased among children. Recently, a strong relationship between solid thyroid nodules and the incidence of thyroid cancer was shown in atomic bomb survivors. To assess the prognosis of benign thyroid nodules in individuals living in the Zhitomir region of Ukraine, around the CNPP, we conducted a follow-up investigation of screening data from 1991 to 2000 in the Ukraine.<h4>Patients and methods</h4>Participants of this study were 160 inhabitants with thyroid nodules (nodule group) and 160 inhabitants without thyroid nodules (normal control group) intially identified by ultrasonography from 1991 to 2000. All participants were aged 0 to 10 years old and lived in the same area at the time of the accident. We performed follow-up screening of participants and assessed thyroid nodules by fine needle aspiration biopsy.<h4>Results</h4>Among the nodule group participants, the number and size of nodules were significantly increased at the follow-up screening compared with the initial screening. No thyroid nodules were observed among the normal control group participants. The prevalence of thyroid abnormality, especially nodules that could be cancerous (malignant or suspicious by fine needle aspiration biopsy), was 7.5% in the nodule group and 0% in the normal control group (P<0.001).<h4>Conclusions</h4>Our study indicated that a thyroid nodule in childhood is a prognostic factor associated with an increase in the number and size of nodules in individuals living in the Zhitomir region of Ukraine.https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23209797/?tool=EBI |
| spellingShingle | Naomi Hayashida Yui Sekitani Jumpei Takahashi Alexander A Kozlovsky Oleksandr K Gutevych Aleksey S Saiko Nina V Nirova Anjela A Petrova Ruslan M Rafalskiy Sergey A Chorny Valery V Daniliuk Masanobu Anami Shunichi Yamashita Noboru Takamura Prognosis of thyroid nodules in individuals living in the Zhitomir region of Ukraine. PLoS ONE |
| title | Prognosis of thyroid nodules in individuals living in the Zhitomir region of Ukraine. |
| title_full | Prognosis of thyroid nodules in individuals living in the Zhitomir region of Ukraine. |
| title_fullStr | Prognosis of thyroid nodules in individuals living in the Zhitomir region of Ukraine. |
| title_full_unstemmed | Prognosis of thyroid nodules in individuals living in the Zhitomir region of Ukraine. |
| title_short | Prognosis of thyroid nodules in individuals living in the Zhitomir region of Ukraine. |
| title_sort | prognosis of thyroid nodules in individuals living in the zhitomir region of ukraine |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23209797/?tool=EBI |
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