The influence of antibody humanization on shark variable domain (VNAR) binding site ensembles

The influence of antibody humanization on shark variable domain (VNAR) binding site ensembles

Sharks and other cartilaginous fish produce new antigen receptor (IgNAR) antibodies, as key part of their humoral immune response and are the phylogenetically oldest living organisms that possess an immunoglobulin (Ig)-based adaptive immune system. IgNAR antibodies are naturally occurring heavy-chai...

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Bibliographic Details
Main Authors:	Monica L. Fernández-Quintero, Anna-Lena M. Fischer, Janik Kokot, Franz Waibl, Clarissa A. Seidler, Klaus R. Liedl
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-09-01
Series:	Frontiers in Immunology
Subjects:	shark VNAR novel biotherapeutic formats humanization molecular dynamics simulations hydrophobicity
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2022.953917/full

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