A Comparison of Shear Wave Elastography between Normal Myometrium, Uterine Fibroids, and Adenomyosis: A Cross-Sectional Study
Background: The differential diagnosis between uterine fibroid and adenomyosis is sometimes difficult; a precise diagnosis is required in women with infertility because of the different choice of treatments. Ultrasound elastography (UE) is a novel technique to evaluate the elasticity or the stiffnes...
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| Format: | Article |
| Language: | English |
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Royan Institute (ACECR), Tehran
2022-01-01
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| Series: | International Journal of Fertility and Sterility |
| Subjects: | |
| Online Access: | https://www.ijfs.ir/article_247952_3122ad5b1207b7146985122196ab9cf4.pdf |
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| author | Sutee Pongpunprut Panyu Paburana Pornphan Wibulpolprasert Wanwisa Waiyaput Morakot Sroyraya Tharintorn Chansoon Areepan Sophonsritsuk |
| author_facet | Sutee Pongpunprut Panyu Paburana Pornphan Wibulpolprasert Wanwisa Waiyaput Morakot Sroyraya Tharintorn Chansoon Areepan Sophonsritsuk |
| author_sort | Sutee Pongpunprut |
| collection | DOAJ |
| description | Background: The differential diagnosis between uterine fibroid and adenomyosis is sometimes difficult; a precise diagnosis is required in women with infertility because of the different choice of treatments. Ultrasound elastography (UE) is a novel technique to evaluate the elasticity or the stiffness of the tissue of interest. The present study aims to compare UE shear wave velocity (SWV) among normal uterine myometrium, uterine fibroid, and adenomyosis, and assess the accuracy of shear wave elastography in the diagnosis of adenomyosis.Materials and Methods: This cross-sectional study recruited 25 subjects for each group (control, adenomyosis, and fibroid) from April 2019 to April 2020. Transvaginal UE using an Aplio 500 (Toshiba Medical Systems, Japan) with ultrasound mapping for point of tissue biopsy was performed for all subjects. The diagnosis was confirmed by histology. Masson’s trichrome staining for collagen was performed and quantified.Results: The mean ± standard deviation (SD) for SWV was 3.44 ± 0.95 m/seconds (control group), 4.63 ± 1.45 m/seconds (adenomyosis group), and 4.53 ± 1.07 m/seconds (fibroid group). The mean SWV differed when comparing normal myometrium and adenomyosis after adjustments for age and endometrial pathology (P=0.019). The cut-off point of SWV at 3.465 m/seconds could differentiate adenomyosis from the normal uterus with an 80% sensitivity, 80% specificity, and an area under the curve (AUC) of 0.80 (95% confidence interval [CI]: 0.68-0.93) (P<0.001). No significant difference in SWV between the adenomyosis and fibroid groups was detected.Conclusion: Shear wave elastography could be an alternative tool to distinguish between normal myometrium and adenomyosis; however, it could not differentiate adenomyosis from uterine fibroid or uterine fibroid from normal myometrium. |
| first_indexed | 2024-04-11T17:26:24Z |
| format | Article |
| id | doaj.art-10058443fd4040bcbb1a15a7a7366c6f |
| institution | Directory Open Access Journal |
| issn | 2008-076X 2008-0778 |
| language | English |
| last_indexed | 2024-04-11T17:26:24Z |
| publishDate | 2022-01-01 |
| publisher | Royan Institute (ACECR), Tehran |
| record_format | Article |
| series | International Journal of Fertility and Sterility |
| spelling | doaj.art-10058443fd4040bcbb1a15a7a7366c6f2022-12-22T04:12:16ZengRoyan Institute (ACECR), TehranInternational Journal of Fertility and Sterility2008-076X2008-07782022-01-01161495410.22074/ijfs.2021.523075.1074247952A Comparison of Shear Wave Elastography between Normal Myometrium, Uterine Fibroids, and Adenomyosis: A Cross-Sectional StudySutee Pongpunprut0Panyu Paburana1Pornphan Wibulpolprasert2Wanwisa Waiyaput3Morakot Sroyraya4Tharintorn Chansoon5Areepan Sophonsritsuk6Department of Obstetrics and Gynaecology, Panyananthaphikkhu Chonprathan Medical Centre, Srinakharinwirot University, Nontaburi, ThailandFoetal and Maternal Medicine Division, Department of Obstetrics and Gynaecology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, ThailandDivision of Diagnostic Radiology, Department of Diagnostic and Therapeutic, Radiology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, ThailandOffice of Research Academic and Innovation, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, ThailandDepartment of Anatomy, Faculty of Science, Mahidol University, Bangkok, ThailandDepartment of Pathology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, ThailandReproductive Endocrinology and Infertility Division, Department of Obstetrics and Gynaecology, Faculty of Medicine, Ramathidodi Hospital, Mahidol University, Bangkok, ThailandBackground: The differential diagnosis between uterine fibroid and adenomyosis is sometimes difficult; a precise diagnosis is required in women with infertility because of the different choice of treatments. Ultrasound elastography (UE) is a novel technique to evaluate the elasticity or the stiffness of the tissue of interest. The present study aims to compare UE shear wave velocity (SWV) among normal uterine myometrium, uterine fibroid, and adenomyosis, and assess the accuracy of shear wave elastography in the diagnosis of adenomyosis.Materials and Methods: This cross-sectional study recruited 25 subjects for each group (control, adenomyosis, and fibroid) from April 2019 to April 2020. Transvaginal UE using an Aplio 500 (Toshiba Medical Systems, Japan) with ultrasound mapping for point of tissue biopsy was performed for all subjects. The diagnosis was confirmed by histology. Masson’s trichrome staining for collagen was performed and quantified.Results: The mean ± standard deviation (SD) for SWV was 3.44 ± 0.95 m/seconds (control group), 4.63 ± 1.45 m/seconds (adenomyosis group), and 4.53 ± 1.07 m/seconds (fibroid group). The mean SWV differed when comparing normal myometrium and adenomyosis after adjustments for age and endometrial pathology (P=0.019). The cut-off point of SWV at 3.465 m/seconds could differentiate adenomyosis from the normal uterus with an 80% sensitivity, 80% specificity, and an area under the curve (AUC) of 0.80 (95% confidence interval [CI]: 0.68-0.93) (P<0.001). No significant difference in SWV between the adenomyosis and fibroid groups was detected.Conclusion: Shear wave elastography could be an alternative tool to distinguish between normal myometrium and adenomyosis; however, it could not differentiate adenomyosis from uterine fibroid or uterine fibroid from normal myometrium.https://www.ijfs.ir/article_247952_3122ad5b1207b7146985122196ab9cf4.pdfadenomyosiselasticityelasticity imaging techniquesleiomyomauterus |
| spellingShingle | Sutee Pongpunprut Panyu Paburana Pornphan Wibulpolprasert Wanwisa Waiyaput Morakot Sroyraya Tharintorn Chansoon Areepan Sophonsritsuk A Comparison of Shear Wave Elastography between Normal Myometrium, Uterine Fibroids, and Adenomyosis: A Cross-Sectional Study International Journal of Fertility and Sterility adenomyosis elasticity elasticity imaging techniques leiomyoma uterus |
| title | A Comparison of Shear Wave Elastography between Normal Myometrium, Uterine Fibroids, and Adenomyosis: A Cross-Sectional Study |
| title_full | A Comparison of Shear Wave Elastography between Normal Myometrium, Uterine Fibroids, and Adenomyosis: A Cross-Sectional Study |
| title_fullStr | A Comparison of Shear Wave Elastography between Normal Myometrium, Uterine Fibroids, and Adenomyosis: A Cross-Sectional Study |
| title_full_unstemmed | A Comparison of Shear Wave Elastography between Normal Myometrium, Uterine Fibroids, and Adenomyosis: A Cross-Sectional Study |
| title_short | A Comparison of Shear Wave Elastography between Normal Myometrium, Uterine Fibroids, and Adenomyosis: A Cross-Sectional Study |
| title_sort | comparison of shear wave elastography between normal myometrium uterine fibroids and adenomyosis a cross sectional study |
| topic | adenomyosis elasticity elasticity imaging techniques leiomyoma uterus |
| url | https://www.ijfs.ir/article_247952_3122ad5b1207b7146985122196ab9cf4.pdf |
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