The Differentiation and Protective Function of Cytolytic CD4 T Cells in Influenza Infection

The Differentiation and Protective Function of Cytolytic CD4 T Cells in Influenza Infection

CD4 T cells that recognize peptide antigen in the context of Class II MHC can differentiate into various subsets that are characterized by their helper functions. However, increasing evidence indicates that CD4 cells with direct cytolytic activity (CD4 CTL) play a role in chronic, as well as, acute...

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Bibliographic Details
Main Authors: Deborah M. Brown, Anna T. Lampe, Aspen M. Workman
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-03-01
Series:Frontiers in Immunology
Subjects:
Influenza A virus
Perforin
granzyme B
CD4 effectors
CD4 cytolytic cells
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00093/full

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