Matrix-mini-tablets of lornoxicam for targeting early morning peak symptoms of rheumatoid arthritis
Objective(s): The aim of present research was to develop matrix-mini-tablets of lornoxicam filled in capsule for targeting early morning peak symptoms of rheumatoid arthritis. Materials and Methods:Matrix-mini-tablets of lornoxicam were prepared by direct compression method using microsomal enzyme d...
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2014-05-01
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| Series: | Iranian Journal of Basic Medical Sciences |
| Subjects: | |
| Online Access: | http://ijbms.mums.ac.ir/pdf_2786_4998782b83db06316dc3d89f521bacbf.html |
| _version_ | 1811267541923790848 |
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| author | Abdul Hadi Mohd Nidagurthi Guggilla Raghavendra Rao Srinivasa Rao Avanapu |
| author_facet | Abdul Hadi Mohd Nidagurthi Guggilla Raghavendra Rao Srinivasa Rao Avanapu |
| author_sort | Abdul Hadi Mohd |
| collection | DOAJ |
| description | Objective(s): The aim of present research was to develop matrix-mini-tablets of lornoxicam filled in capsule for targeting early morning peak symptoms of rheumatoid arthritis. Materials and Methods:Matrix-mini-tablets of lornoxicam were prepared by direct compression method using microsomal enzyme dependent and pH-sensitive polymers which were further filled into an empty HPMC capsule. To assess the compatibility, FT-IR and DSC studies for pure drug, polymers and their physical mixture were performed. The formulated batches were subjected to physicochemical studies, estimation of drug content, in vitro drug release, drug release kinetics, and stability studies. Results: When FTIR and DSC studies were performed it was found that there was no interaction between lornoxicam and polymers which used. All the physicochemical properties of prepared matrix-mini-tablets were found to be in normal limits. The percentage of drug content was found to be 99.60±0.07%. Our optimized matrix mini-tablets-filled-capsule formulation F30 released lornoxicam after a lag time of 5.02±0.92 hr, 95.48±0.65 % at the end of 8 hr and 99.90±0.83 % at the end of 12 hr. Stability was also found for this formulation as per the guidelines of International Conference on Harmonisation of Technical Requirements of Pharmaceuticals for Human Use. Conclusion: A novel colon targeted delivery system of lornoxicam was successfully developed by filling matrix-mini-tablets into an empty HPMC capsule shell for targeting early morning peak symptoms of rheumatoid arthritis. |
| first_indexed | 2024-04-12T21:04:22Z |
| format | Article |
| id | doaj.art-10069eba7f664ba290c903d1abca0796 |
| institution | Directory Open Access Journal |
| issn | 2008-3866 2008-3874 |
| language | English |
| last_indexed | 2024-04-12T21:04:22Z |
| publishDate | 2014-05-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Basic Medical Sciences |
| spelling | doaj.art-10069eba7f664ba290c903d1abca07962022-12-22T03:16:45ZengMashhad University of Medical SciencesIranian Journal of Basic Medical Sciences2008-38662008-38742014-05-011753573692786Matrix-mini-tablets of lornoxicam for targeting early morning peak symptoms of rheumatoid arthritisAbdul Hadi Mohd0Nidagurthi Guggilla Raghavendra Rao1Srinivasa Rao Avanapu2Department of Pharmaceutics, Bhaskar Pharmacy College (JB Group of Educational Institutions), Yenkapally (V), Moinabad (M), R.R.District, Hyderabad-500075, Andhra Pradesh, IndiaJyothishmathi Institute of Pharmaceutical Science, Thimmapur, Karimnagar -505481, Andhra Pradesh, IndiaBhaskar Pharmacy College (JB Group of Educational Institutions), Yenkapally (V), Moinabad (M), R.R.District, Hyderabad-500075, Andhra Pradesh, IndiaObjective(s): The aim of present research was to develop matrix-mini-tablets of lornoxicam filled in capsule for targeting early morning peak symptoms of rheumatoid arthritis. Materials and Methods:Matrix-mini-tablets of lornoxicam were prepared by direct compression method using microsomal enzyme dependent and pH-sensitive polymers which were further filled into an empty HPMC capsule. To assess the compatibility, FT-IR and DSC studies for pure drug, polymers and their physical mixture were performed. The formulated batches were subjected to physicochemical studies, estimation of drug content, in vitro drug release, drug release kinetics, and stability studies. Results: When FTIR and DSC studies were performed it was found that there was no interaction between lornoxicam and polymers which used. All the physicochemical properties of prepared matrix-mini-tablets were found to be in normal limits. The percentage of drug content was found to be 99.60±0.07%. Our optimized matrix mini-tablets-filled-capsule formulation F30 released lornoxicam after a lag time of 5.02±0.92 hr, 95.48±0.65 % at the end of 8 hr and 99.90±0.83 % at the end of 12 hr. Stability was also found for this formulation as per the guidelines of International Conference on Harmonisation of Technical Requirements of Pharmaceuticals for Human Use. Conclusion: A novel colon targeted delivery system of lornoxicam was successfully developed by filling matrix-mini-tablets into an empty HPMC capsule shell for targeting early morning peak symptoms of rheumatoid arthritis.http://ijbms.mums.ac.ir/pdf_2786_4998782b83db06316dc3d89f521bacbf.htmlLornoxicamMatrix-mini-tablets-filled-capsule systemMicrosomal enzyme depen- dent polymerspH-sensitive polymersrheumatoid arthritis |
| spellingShingle | Abdul Hadi Mohd Nidagurthi Guggilla Raghavendra Rao Srinivasa Rao Avanapu Matrix-mini-tablets of lornoxicam for targeting early morning peak symptoms of rheumatoid arthritis Iranian Journal of Basic Medical Sciences Lornoxicam Matrix-mini-tablets-filled-capsule system Microsomal enzyme depen- dent polymers pH-sensitive polymers rheumatoid arthritis |
| title | Matrix-mini-tablets of lornoxicam for targeting early morning peak symptoms of rheumatoid arthritis |
| title_full | Matrix-mini-tablets of lornoxicam for targeting early morning peak symptoms of rheumatoid arthritis |
| title_fullStr | Matrix-mini-tablets of lornoxicam for targeting early morning peak symptoms of rheumatoid arthritis |
| title_full_unstemmed | Matrix-mini-tablets of lornoxicam for targeting early morning peak symptoms of rheumatoid arthritis |
| title_short | Matrix-mini-tablets of lornoxicam for targeting early morning peak symptoms of rheumatoid arthritis |
| title_sort | matrix mini tablets of lornoxicam for targeting early morning peak symptoms of rheumatoid arthritis |
| topic | Lornoxicam Matrix-mini-tablets-filled-capsule system Microsomal enzyme depen- dent polymers pH-sensitive polymers rheumatoid arthritis |
| url | http://ijbms.mums.ac.ir/pdf_2786_4998782b83db06316dc3d89f521bacbf.html |
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