Renal Expression and Localization of the Receptor for (Pro)renin and Its Ligands in Rodent Models of Diabetes, Metabolic Syndrome, and Age-Dependent Focal and Segmental Glomerulosclerosis

Renal Expression and Localization of the Receptor for (Pro)renin and Its Ligands in Rodent Models of Diabetes, Metabolic Syndrome, and Age-Dependent Focal and Segmental Glomerulosclerosis

The (pro)renin receptor ((P)RR), a versatile protein found in various organs, including the kidney, is implicated in cardiometabolic conditions like diabetes, hypertension, and dyslipidemia, potentially contributing to organ damage. Importantly, changes in (pro)renin/(P)RR system localization during...

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Bibliographic Details
Main Authors: Carla Iacobini, Martina Vitale, Federica Sentinelli, Jonida Haxhi, Giuseppe Pugliese, Stefano Menini
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Series:International Journal of Molecular Sciences
Subjects:
cyclooxygenase 2
diabetic nephropathy
hyperglycemia
Milan normotensive rats
soluble prorenin receptor
podocytes
Online Access:https://www.mdpi.com/1422-0067/25/4/2217

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