Functional and Structural Characterization of Diverse NfsB Chloramphenicol Reductase Enzymes from Human Pathogens

Functional and Structural Characterization of Diverse NfsB Chloramphenicol Reductase Enzymes from Human Pathogens

ABSTRACT Phylogenetically diverse bacteria can carry out chloramphenicol reduction, but only a single enzyme has been described that efficiently catalyzes this reaction, the NfsB nitroreductase from Haemophilus influenzae strain KW20. Here, we tested the hypothesis that some NfsB homologs function a...

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Bibliographic Details
Main Authors: Michael W. Mullowney, Natalia I. Maltseva, Michael Endres, Youngchang Kim, Andrzej Joachimiak, Terence S. Crofts
Format: Article
Language:English
Published: American Society for Microbiology 2022-04-01
Series:Microbiology Spectrum
Subjects:
antibiotic resistance
chloramphenicol
crystal structure
Haemophilus influenzae
Neisseria
NfsB
Online Access:https://journals.asm.org/doi/10.1128/spectrum.00139-22

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