Initiation of HIV Reverse Transcription
Reverse transcription of retroviral genomes into double stranded DNA is a key event for viral replication. The very first stage of HIV reverse transcription, the initiation step, involves viral and cellular partners that are selectively packaged into the viral particle, leading to an RNA/protein com...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2010-01-01
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| Series: | Viruses |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1999-4915/2/1/213/ |
| _version_ | 1818057119323127808 |
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| author | Roland Marquet Chantal Ehresmann Catherine Isel |
| author_facet | Roland Marquet Chantal Ehresmann Catherine Isel |
| author_sort | Roland Marquet |
| collection | DOAJ |
| description | Reverse transcription of retroviral genomes into double stranded DNA is a key event for viral replication. The very first stage of HIV reverse transcription, the initiation step, involves viral and cellular partners that are selectively packaged into the viral particle, leading to an RNA/protein complex with very specific structural and functional features, some of which being, in the case of HIV-1, linked to particular isolates. Recent understanding of the tight spatio-temporal regulation of reverse transcription and its importance for viral infectivity further points toward reverse transcription and potentially its initiation step as an important drug target. |
| first_indexed | 2024-12-10T12:39:40Z |
| format | Article |
| id | doaj.art-1008713060dc4d769917a0ac2a2972f5 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-12-10T12:39:40Z |
| publishDate | 2010-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-1008713060dc4d769917a0ac2a2972f52022-12-22T01:48:33ZengMDPI AGViruses1999-49152010-01-012121324310.3390/v2010213Initiation of HIV Reverse TranscriptionRoland MarquetChantal EhresmannCatherine IselReverse transcription of retroviral genomes into double stranded DNA is a key event for viral replication. The very first stage of HIV reverse transcription, the initiation step, involves viral and cellular partners that are selectively packaged into the viral particle, leading to an RNA/protein complex with very specific structural and functional features, some of which being, in the case of HIV-1, linked to particular isolates. Recent understanding of the tight spatio-temporal regulation of reverse transcription and its importance for viral infectivity further points toward reverse transcription and potentially its initiation step as an important drug target.http://www.mdpi.com/1999-4915/2/1/213/retrovirusreverse transcriptasetRNA |
| spellingShingle | Roland Marquet Chantal Ehresmann Catherine Isel Initiation of HIV Reverse Transcription Viruses retrovirus reverse transcriptase tRNA |
| title | Initiation of HIV Reverse Transcription |
| title_full | Initiation of HIV Reverse Transcription |
| title_fullStr | Initiation of HIV Reverse Transcription |
| title_full_unstemmed | Initiation of HIV Reverse Transcription |
| title_short | Initiation of HIV Reverse Transcription |
| title_sort | initiation of hiv reverse transcription |
| topic | retrovirus reverse transcriptase tRNA |
| url | http://www.mdpi.com/1999-4915/2/1/213/ |
| work_keys_str_mv | AT rolandmarquet initiationofhivreversetranscription AT chantalehresmann initiationofhivreversetranscription AT catherineisel initiationofhivreversetranscription |