The Role of Cdkn1A-Interacting Zinc Finger Protein 1 (CIZ1) in DNA Replication and Pathophysiology
Cdkn1A-interacting zinc finger protein 1 (CIZ1) was first identified in a yeast-2-hybrid system searching for interacting proteins of CDK2 inhibitor p21Cip1/Waf1. Ciz1 also binds to CDK2, cyclin A, cyclin E, CDC6, PCNA, TCF4 and estrogen receptor-α. Recent studies reveal numerous biological function...
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| Format: | Article |
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MDPI AG
2016-02-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | http://www.mdpi.com/1422-0067/17/2/212 |
| _version_ | 1811293247015747584 |
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| author | Qiang Liu Na Niu Youichiro Wada Ju Liu |
| author_facet | Qiang Liu Na Niu Youichiro Wada Ju Liu |
| author_sort | Qiang Liu |
| collection | DOAJ |
| description | Cdkn1A-interacting zinc finger protein 1 (CIZ1) was first identified in a yeast-2-hybrid system searching for interacting proteins of CDK2 inhibitor p21Cip1/Waf1. Ciz1 also binds to CDK2, cyclin A, cyclin E, CDC6, PCNA, TCF4 and estrogen receptor-α. Recent studies reveal numerous biological functions of CIZ1 in DNA replication, cell proliferation, and differentiation. In addition, splicing variants of CIZ1 mRNA is associated with a variety of cancers and Alzheimer’s disease, and mutations of the CIZ1 gene lead to cervical dystonia. CIZ1 expression is increased in cancers and rheumatoid arthritis. In this review, we will summarize the biological functions and molecular mechanisms of CIZ1 in these physiological and pathological processes. |
| first_indexed | 2024-04-13T04:58:35Z |
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| id | doaj.art-100b6694280c4bef840e0a9f6a627afb |
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| issn | 1422-0067 |
| language | English |
| last_indexed | 2024-04-13T04:58:35Z |
| publishDate | 2016-02-01 |
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| spelling | doaj.art-100b6694280c4bef840e0a9f6a627afb2022-12-22T03:01:25ZengMDPI AGInternational Journal of Molecular Sciences1422-00672016-02-0117221210.3390/ijms17020212ijms17020212The Role of Cdkn1A-Interacting Zinc Finger Protein 1 (CIZ1) in DNA Replication and PathophysiologyQiang Liu0Na Niu1Youichiro Wada2Ju Liu3Medical Research Center, Shandong Provincial Qianfoshan Hospital, Shandong University, 16766 Jingshi Road, Jinan 250014, ChinaDepartment of Pediatrics, Shandong Provincial Hospital Affiliated to Shandong University, 324 Jingwu Road, Jinan 250021, ChinaThe Research Center for Advanced Science and Technology, and Isotope Science Center, The University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo 153-8904, JapanMedical Research Center, Shandong Provincial Qianfoshan Hospital, Shandong University, 16766 Jingshi Road, Jinan 250014, ChinaCdkn1A-interacting zinc finger protein 1 (CIZ1) was first identified in a yeast-2-hybrid system searching for interacting proteins of CDK2 inhibitor p21Cip1/Waf1. Ciz1 also binds to CDK2, cyclin A, cyclin E, CDC6, PCNA, TCF4 and estrogen receptor-α. Recent studies reveal numerous biological functions of CIZ1 in DNA replication, cell proliferation, and differentiation. In addition, splicing variants of CIZ1 mRNA is associated with a variety of cancers and Alzheimer’s disease, and mutations of the CIZ1 gene lead to cervical dystonia. CIZ1 expression is increased in cancers and rheumatoid arthritis. In this review, we will summarize the biological functions and molecular mechanisms of CIZ1 in these physiological and pathological processes.http://www.mdpi.com/1422-0067/17/2/212CIZ1DNA replicationalternative splicingcell cycle |
| spellingShingle | Qiang Liu Na Niu Youichiro Wada Ju Liu The Role of Cdkn1A-Interacting Zinc Finger Protein 1 (CIZ1) in DNA Replication and Pathophysiology International Journal of Molecular Sciences CIZ1 DNA replication alternative splicing cell cycle |
| title | The Role of Cdkn1A-Interacting Zinc Finger Protein 1 (CIZ1) in DNA Replication and Pathophysiology |
| title_full | The Role of Cdkn1A-Interacting Zinc Finger Protein 1 (CIZ1) in DNA Replication and Pathophysiology |
| title_fullStr | The Role of Cdkn1A-Interacting Zinc Finger Protein 1 (CIZ1) in DNA Replication and Pathophysiology |
| title_full_unstemmed | The Role of Cdkn1A-Interacting Zinc Finger Protein 1 (CIZ1) in DNA Replication and Pathophysiology |
| title_short | The Role of Cdkn1A-Interacting Zinc Finger Protein 1 (CIZ1) in DNA Replication and Pathophysiology |
| title_sort | role of cdkn1a interacting zinc finger protein 1 ciz1 in dna replication and pathophysiology |
| topic | CIZ1 DNA replication alternative splicing cell cycle |
| url | http://www.mdpi.com/1422-0067/17/2/212 |
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