Current and future opportunities of autodissemination of pyriproxyfen approach for malaria vector control in urban and rural Africa [version 3; peer review: 3 approved]
Despite the progress made in reducing malaria burden, new ways to address the increasing challenges of insecticide resistance and the invasion and spread of exotic malaria vectors such as Anopheles stephensi in Africa are urgently needed. While African countries are adopting larviciding as a complem...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wellcome
2023-10-01
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| Series: | Wellcome Open Research |
| Subjects: | |
| Online Access: | https://wellcomeopenresearch.org/articles/8-119/v3 |
| _version_ | 1797644872186855424 |
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| author | Augustino Thabiti Mmbaga Hamisi Juma Kunambi Amos Justinian Ngonzi Arnold Sadikiel Mmbando Felista Simon Tarimo Dickson Wilson Lwetoijera |
| author_facet | Augustino Thabiti Mmbaga Hamisi Juma Kunambi Amos Justinian Ngonzi Arnold Sadikiel Mmbando Felista Simon Tarimo Dickson Wilson Lwetoijera |
| author_sort | Augustino Thabiti Mmbaga |
| collection | DOAJ |
| description | Despite the progress made in reducing malaria burden, new ways to address the increasing challenges of insecticide resistance and the invasion and spread of exotic malaria vectors such as Anopheles stephensi in Africa are urgently needed. While African countries are adopting larviciding as a complementary intervention for malaria vector control, the autodissemination technology has the potential to overcome barriers associated with the identification and treatment of prolific habitats that impede conventional larviciding approaches in rural settings. The autodissemination technology as a “lure and release” strategy works by exploiting the resting behavior of gravid mosquitoes to transfer lethal concentration of biological or chemical insecticide such as pyriproxyfen (PPF), an insect growth regulator (IGRs) to their oviposition sites and result in adult emergence inhibition. Despite the evidence of the autodissemination approach to control other mosquito-borne diseases, there is growing and promising evidence for its use in controlling malaria vectors in Africa, which highlights the momentous research that needs to be sustained. This article reviews the evidence for efficacy of the autodissemination approach using PPF and discusses its potential as efficient and affordable complementary malaria vector control intervention in Africa. In the previous studies that were done in controlled semi-field environments, autodissemination with PPF demonstrated its potential in reducing densities of captive population of malaria vectors such as Anopheles gambiae and Anopheles arabiensis. Of importance, empirical evidence and biology-informed mathematical models to demonstrate the utility of the autodissemination approach to control wild populations of malaria vectors under field environment either alone or in combination with other tools are underway. Among others, the key determining factors for future introduction of this approach at scale is having scalable autodissemination devices, optimized PPF formulations, assess its integration/complementarity to existing conventional larviciding, and community perception and acceptance of the autodissemination approach. |
| first_indexed | 2024-03-11T14:37:41Z |
| format | Article |
| id | doaj.art-100f300b10cd4f08b7cdd99ce4f7e9d9 |
| institution | Directory Open Access Journal |
| issn | 2398-502X |
| language | English |
| last_indexed | 2024-03-11T14:37:41Z |
| publishDate | 2023-10-01 |
| publisher | Wellcome |
| record_format | Article |
| series | Wellcome Open Research |
| spelling | doaj.art-100f300b10cd4f08b7cdd99ce4f7e9d92023-10-31T01:00:01ZengWellcomeWellcome Open Research2398-502X2023-10-01822441Current and future opportunities of autodissemination of pyriproxyfen approach for malaria vector control in urban and rural Africa [version 3; peer review: 3 approved]Augustino Thabiti Mmbaga0Hamisi Juma Kunambi1Amos Justinian Ngonzi2Arnold Sadikiel Mmbando3Felista Simon Tarimo4Dickson Wilson Lwetoijera5https://orcid.org/0000-0003-2544-0451Environmental Health and Ecological Science Department, Ifakara Health Institute, Ifakara, Morogoro, P.O. Box 53, TanzaniaEnvironmental Health and Ecological Science Department, Ifakara Health Institute, Ifakara, Morogoro, P.O. Box 53, TanzaniaEnvironmental Health and Ecological Science Department, Ifakara Health Institute, Ifakara, Morogoro, P.O. Box 53, TanzaniaEnvironmental Health and Ecological Science Department, Ifakara Health Institute, Ifakara, Morogoro, P.O. Box 53, TanzaniaEnvironmental Health and Ecological Science Department, Ifakara Health Institute, Ifakara, Morogoro, P.O. Box 53, TanzaniaEnvironmental Health and Ecological Science Department, Ifakara Health Institute, Ifakara, Morogoro, P.O. Box 53, TanzaniaDespite the progress made in reducing malaria burden, new ways to address the increasing challenges of insecticide resistance and the invasion and spread of exotic malaria vectors such as Anopheles stephensi in Africa are urgently needed. While African countries are adopting larviciding as a complementary intervention for malaria vector control, the autodissemination technology has the potential to overcome barriers associated with the identification and treatment of prolific habitats that impede conventional larviciding approaches in rural settings. The autodissemination technology as a “lure and release” strategy works by exploiting the resting behavior of gravid mosquitoes to transfer lethal concentration of biological or chemical insecticide such as pyriproxyfen (PPF), an insect growth regulator (IGRs) to their oviposition sites and result in adult emergence inhibition. Despite the evidence of the autodissemination approach to control other mosquito-borne diseases, there is growing and promising evidence for its use in controlling malaria vectors in Africa, which highlights the momentous research that needs to be sustained. This article reviews the evidence for efficacy of the autodissemination approach using PPF and discusses its potential as efficient and affordable complementary malaria vector control intervention in Africa. In the previous studies that were done in controlled semi-field environments, autodissemination with PPF demonstrated its potential in reducing densities of captive population of malaria vectors such as Anopheles gambiae and Anopheles arabiensis. Of importance, empirical evidence and biology-informed mathematical models to demonstrate the utility of the autodissemination approach to control wild populations of malaria vectors under field environment either alone or in combination with other tools are underway. Among others, the key determining factors for future introduction of this approach at scale is having scalable autodissemination devices, optimized PPF formulations, assess its integration/complementarity to existing conventional larviciding, and community perception and acceptance of the autodissemination approach.https://wellcomeopenresearch.org/articles/8-119/v3Autodissemination Pyriproxyfen Malaria Larval source managementeng |
| spellingShingle | Augustino Thabiti Mmbaga Hamisi Juma Kunambi Amos Justinian Ngonzi Arnold Sadikiel Mmbando Felista Simon Tarimo Dickson Wilson Lwetoijera Current and future opportunities of autodissemination of pyriproxyfen approach for malaria vector control in urban and rural Africa [version 3; peer review: 3 approved] Wellcome Open Research Autodissemination Pyriproxyfen Malaria Larval source management eng |
| title | Current and future opportunities of autodissemination of pyriproxyfen approach for malaria vector control in urban and rural Africa [version 3; peer review: 3 approved] |
| title_full | Current and future opportunities of autodissemination of pyriproxyfen approach for malaria vector control in urban and rural Africa [version 3; peer review: 3 approved] |
| title_fullStr | Current and future opportunities of autodissemination of pyriproxyfen approach for malaria vector control in urban and rural Africa [version 3; peer review: 3 approved] |
| title_full_unstemmed | Current and future opportunities of autodissemination of pyriproxyfen approach for malaria vector control in urban and rural Africa [version 3; peer review: 3 approved] |
| title_short | Current and future opportunities of autodissemination of pyriproxyfen approach for malaria vector control in urban and rural Africa [version 3; peer review: 3 approved] |
| title_sort | current and future opportunities of autodissemination of pyriproxyfen approach for malaria vector control in urban and rural africa version 3 peer review 3 approved |
| topic | Autodissemination Pyriproxyfen Malaria Larval source management eng |
| url | https://wellcomeopenresearch.org/articles/8-119/v3 |
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