Cancer Stem Cells and Glioblastoma: Time for Innovative Biomarkers of Radio-Resistance?
Despite countless papers in the field of radioresistance, researchers are still far from clearly understanding the mechanisms triggered in glioblastoma. Cancer stem cells (CSC) are important to the growth and spread of cancer, according to many studies. In addition, more recently, it has been sugges...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-09-01
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| Series: | Biology |
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| Online Access: | https://www.mdpi.com/2079-7737/12/10/1295 |
| _version_ | 1827721658464468992 |
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| author | Francesco Pasqualetti Mario Miniati Alessandra Gonnelli Giovanni Gadducci Noemi Giannini Laura Palagini Maricia Mancino Taiusha Fuentes Fabiola Paiar |
| author_facet | Francesco Pasqualetti Mario Miniati Alessandra Gonnelli Giovanni Gadducci Noemi Giannini Laura Palagini Maricia Mancino Taiusha Fuentes Fabiola Paiar |
| author_sort | Francesco Pasqualetti |
| collection | DOAJ |
| description | Despite countless papers in the field of radioresistance, researchers are still far from clearly understanding the mechanisms triggered in glioblastoma. Cancer stem cells (CSC) are important to the growth and spread of cancer, according to many studies. In addition, more recently, it has been suggested that CSCs have an impact on glioblastoma patients’ prognosis, tumor aggressiveness, and treatment outcomes. In reviewing this new area of biology, we will provide a summary of the most recent research on CSCs and their role in the response to radio-chemotherapy in GB. In this review, we will examine the radiosensitivity of stem cells. Moreover, we summarize the current knowledge of the biomarkers of stemness and evaluate their potential function in the study of radiosensitivity. |
| first_indexed | 2024-03-10T21:25:08Z |
| format | Article |
| id | doaj.art-100f8a613b164b04992144d703901e34 |
| institution | Directory Open Access Journal |
| issn | 2079-7737 |
| language | English |
| last_indexed | 2024-03-10T21:25:08Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biology |
| spelling | doaj.art-100f8a613b164b04992144d703901e342023-11-19T15:43:16ZengMDPI AGBiology2079-77372023-09-011210129510.3390/biology12101295Cancer Stem Cells and Glioblastoma: Time for Innovative Biomarkers of Radio-Resistance?Francesco Pasqualetti0Mario Miniati1Alessandra Gonnelli2Giovanni Gadducci3Noemi Giannini4Laura Palagini5Maricia Mancino6Taiusha Fuentes7Fabiola Paiar8Radiation Oncology Unit, Azienda Ospedaliero-Universitaria Pisana, Via Roma 67, 56100 Pisa, ItalyDepartment of Clinical and Experimental Medicine, University of Pisa, Italy, Via Roma 67, 56100 Pisa, ItalyRadiation Oncology Unit, Azienda Ospedaliero-Universitaria Pisana, Via Roma 67, 56100 Pisa, ItalyRadiation Oncology Unit, Azienda Ospedaliero-Universitaria Pisana, Via Roma 67, 56100 Pisa, ItalyRadiation Oncology Unit, Azienda Ospedaliero-Universitaria Pisana, Via Roma 67, 56100 Pisa, ItalyDepartment of Clinical and Experimental Medicine, University of Pisa, Italy, Via Roma 67, 56100 Pisa, ItalyRadiation Oncology Unit, Azienda Ospedaliero-Universitaria Pisana, Via Roma 67, 56100 Pisa, ItalyRadiation Oncology Unit, Azienda Ospedaliero-Universitaria Pisana, Via Roma 67, 56100 Pisa, ItalyRadiation Oncology Unit, Azienda Ospedaliero-Universitaria Pisana, Via Roma 67, 56100 Pisa, ItalyDespite countless papers in the field of radioresistance, researchers are still far from clearly understanding the mechanisms triggered in glioblastoma. Cancer stem cells (CSC) are important to the growth and spread of cancer, according to many studies. In addition, more recently, it has been suggested that CSCs have an impact on glioblastoma patients’ prognosis, tumor aggressiveness, and treatment outcomes. In reviewing this new area of biology, we will provide a summary of the most recent research on CSCs and their role in the response to radio-chemotherapy in GB. In this review, we will examine the radiosensitivity of stem cells. Moreover, we summarize the current knowledge of the biomarkers of stemness and evaluate their potential function in the study of radiosensitivity.https://www.mdpi.com/2079-7737/12/10/1295glioblastomaradioresistancecancer stem cellsbiomarkers |
| spellingShingle | Francesco Pasqualetti Mario Miniati Alessandra Gonnelli Giovanni Gadducci Noemi Giannini Laura Palagini Maricia Mancino Taiusha Fuentes Fabiola Paiar Cancer Stem Cells and Glioblastoma: Time for Innovative Biomarkers of Radio-Resistance? Biology glioblastoma radioresistance cancer stem cells biomarkers |
| title | Cancer Stem Cells and Glioblastoma: Time for Innovative Biomarkers of Radio-Resistance? |
| title_full | Cancer Stem Cells and Glioblastoma: Time for Innovative Biomarkers of Radio-Resistance? |
| title_fullStr | Cancer Stem Cells and Glioblastoma: Time for Innovative Biomarkers of Radio-Resistance? |
| title_full_unstemmed | Cancer Stem Cells and Glioblastoma: Time for Innovative Biomarkers of Radio-Resistance? |
| title_short | Cancer Stem Cells and Glioblastoma: Time for Innovative Biomarkers of Radio-Resistance? |
| title_sort | cancer stem cells and glioblastoma time for innovative biomarkers of radio resistance |
| topic | glioblastoma radioresistance cancer stem cells biomarkers |
| url | https://www.mdpi.com/2079-7737/12/10/1295 |
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