A spontaneous ovarian teratoma in an FVB/n female mouse: Case report and literature review
Background: Teratomas are rare types of germ cell neoplasms composed of various differentiated or undifferentiated tissues. Case Description: A 25-week-old female control FVB/n mouse in a 4-week toxicity study presented abdominal distension and poor body condition. It was euthanized, and the necr...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Tripoli University
2023-09-01
|
| Series: | Open Veterinary Journal |
| Subjects: | |
| Online Access: | https://www.openveterinaryjournal.com/?mno=147336 |
| _version_ | 1827790813371826176 |
|---|---|
| author | Paula Alexandra Martins de-Oliveira Ana I. Faustino-Rocha Rui M. Gil da-Costa Elisabete Nascimento Goncalves Ana Margarida Calado Catarina Jota Baptista Adelina Gama Fernanda Seixas |
| author_facet | Paula Alexandra Martins de-Oliveira Ana I. Faustino-Rocha Rui M. Gil da-Costa Elisabete Nascimento Goncalves Ana Margarida Calado Catarina Jota Baptista Adelina Gama Fernanda Seixas |
| author_sort | Paula Alexandra Martins de-Oliveira |
| collection | DOAJ |
| description | Background:
Teratomas are rare types of germ cell neoplasms composed of various differentiated or undifferentiated tissues.
Case Description:
A 25-week-old female control FVB/n mouse in a 4-week toxicity study presented abdominal distension and poor body condition. It was euthanized, and the necropsy exam revealed a large mass connected to the tip of the right uterine horn, occupying the entire abdominal cavity. Microscopically, this mass showed areas of epidermal differentiation, with laminated keratin and sebaceous glands, differentiation into respiratory and digestive epithelium, cartilage, bone, and extensive areas of differentiation into the nervous tissue, being classified as an ovarian teratoma.
Conclusion:
As far as authors know, the occurrence of ovarian teratomas in FVB/n mouse strain has never been previously described. [Open Vet J 2023; 13(9.000): 1223-1227] |
| first_indexed | 2024-03-11T17:37:27Z |
| format | Article |
| id | doaj.art-100f91a96fbc432aafe7b7263239e965 |
| institution | Directory Open Access Journal |
| issn | 2226-4485 |
| language | English |
| last_indexed | 2024-03-11T17:37:27Z |
| publishDate | 2023-09-01 |
| publisher | Tripoli University |
| record_format | Article |
| series | Open Veterinary Journal |
| spelling | doaj.art-100f91a96fbc432aafe7b7263239e9652023-10-18T15:28:28ZengTripoli UniversityOpen Veterinary Journal2226-44852023-09-011391223122710.5455/OVJ.2023.v13.i9.19147336A spontaneous ovarian teratoma in an FVB/n female mouse: Case report and literature reviewPaula Alexandra Martins de-Oliveira0Ana I. Faustino-Rocha1Rui M. Gil da-Costa2Elisabete Nascimento Goncalves3Ana Margarida Calado4Catarina Jota Baptista5Adelina Gama6Fernanda Seixas71 Centre for the Research and Technology of Agro-Environmental and Biological Sciences (CITAB), Inov4Agro, University of Tras-os-Montes and Alto Douro (UTAD), 5000-801, Vila Real, Portugal 2 Institute for Innovation, Capacity Building and Sustainability of Agri-food Production (Inov4Agro), 5000-801, Vila Real, Portugal 3 Department of Veterinary Sciences, UTAD, 5000-801, Vila Real, Portugal 1 Centre for the Research and Technology of Agro-Environmental and Biological Sciences (CITAB), Inov4Agro, University of Tras-os-Montes and Alto Douro (UTAD), 5000-801, Vila Real, Portugal 2 Institute for Innovation, Capacity Building and Sustainability of Agri-food Production (Inov4Agro), 5000-801, Vila Real, Portugal4 Department of Zootechnics, School of Sciences and Technology, University of Évora, 7004-516 Évora, Portugal 5 Comprehensive Health Research Center, 7004-516 Évora, Portugal 1 Centre for the Research and Technology of Agro-Environmental and Biological Sciences (CITAB), Inov4Agro, University of Tras-os-Montes and Alto Douro (UTAD), 5000-801, Vila Real, Portugal 2 Institute for Innovation, Capacity Building and Sustainability of Agri-food Production (Inov4Agro), 5000-801, Vila Real, Portugal6 Molecular Oncology and Viral Pathology Group, Research Center of IPO Porto (CI-IPOP)/RISE@CI-IPOP (Health Research Network), Portuguese Oncology Institute of Porto (IPO Porto)/Porto Comprehensive Cancer Center (Porto.CCC), 4200-072 Porto, Portugal 7Biomedicine Research Center (CEBIMED), Faculty of Health Sciences, Fernando Pessoa University, 4249-004 Porto, Portugal 8Research Department, LPCC-Portuguese League Against Cancer (NRNorte), 4200-172 Porto, Portugal 9 Post-graduate Programme in Adult Health (PPGSAD), Morphology Department and University Hospital (HUUFMA), Federal University of Maranhao (UFMA), Sao Luís 65080-805, Brazil 10Associate Laboratory for Animal and Veterinary Science (AL4AnimalS), Animal and Veterinary Research Centre (CECAV), UTAD, 5000-801 Vila Real, Portugal 1 Centre for the Research and Technology of Agro-Environmental and Biological Sciences (CITAB), Inov4Agro, University of Tras-os-Montes and Alto Douro (UTAD), 5000-801, Vila Real, Portugal 2 Institute for Innovation, Capacity Building and Sustainability of Agri-food Production (Inov4Agro), 5000-801, Vila Real, Portugal 3 Department of Veterinary Sciences, UTAD, 5000-801, Vila Real, Portugal 10Associate Laboratory for Animal and Veterinary Science (AL4AnimalS), Animal and Veterinary Research Centre (CECAV), UTAD, 5000-801 Vila Real, Portugal 1 Centre for the Research and Technology of Agro-Environmental and Biological Sciences (CITAB), Inov4Agro, University of Tras-os-Montes and Alto Douro (UTAD), 5000-801, Vila Real, Portugal 2 Institute for Innovation, Capacity Building and Sustainability of Agri-food Production (Inov4Agro), 5000-801, Vila Real, Portugal 3 Department of Veterinary Sciences, UTAD, 5000-801, Vila Real, Portugal11IBIOMED – Instituto de Biomedicina, Universidad de León, León, Spain. 12Faculty of Veterinary of Medicine, Lusófona University of Humanities and Technology, Lisbon, Portugal. 3 Department of Veterinary Sciences, UTAD, 5000-801, Vila Real, PortugalBackground: Teratomas are rare types of germ cell neoplasms composed of various differentiated or undifferentiated tissues. Case Description: A 25-week-old female control FVB/n mouse in a 4-week toxicity study presented abdominal distension and poor body condition. It was euthanized, and the necropsy exam revealed a large mass connected to the tip of the right uterine horn, occupying the entire abdominal cavity. Microscopically, this mass showed areas of epidermal differentiation, with laminated keratin and sebaceous glands, differentiation into respiratory and digestive epithelium, cartilage, bone, and extensive areas of differentiation into the nervous tissue, being classified as an ovarian teratoma. Conclusion: As far as authors know, the occurrence of ovarian teratomas in FVB/n mouse strain has never been previously described. [Open Vet J 2023; 13(9.000): 1223-1227]https://www.openveterinaryjournal.com/?mno=147336mouseovaryrodentteratoma |
| spellingShingle | Paula Alexandra Martins de-Oliveira Ana I. Faustino-Rocha Rui M. Gil da-Costa Elisabete Nascimento Goncalves Ana Margarida Calado Catarina Jota Baptista Adelina Gama Fernanda Seixas A spontaneous ovarian teratoma in an FVB/n female mouse: Case report and literature review Open Veterinary Journal mouse ovary rodent teratoma |
| title | A spontaneous ovarian teratoma in an FVB/n female mouse: Case report and literature review |
| title_full | A spontaneous ovarian teratoma in an FVB/n female mouse: Case report and literature review |
| title_fullStr | A spontaneous ovarian teratoma in an FVB/n female mouse: Case report and literature review |
| title_full_unstemmed | A spontaneous ovarian teratoma in an FVB/n female mouse: Case report and literature review |
| title_short | A spontaneous ovarian teratoma in an FVB/n female mouse: Case report and literature review |
| title_sort | spontaneous ovarian teratoma in an fvb n female mouse case report and literature review |
| topic | mouse ovary rodent teratoma |
| url | https://www.openveterinaryjournal.com/?mno=147336 |
| work_keys_str_mv | AT paulaalexandramartinsdeoliveira aspontaneousovarianteratomainanfvbnfemalemousecasereportandliteraturereview AT anaifaustinorocha aspontaneousovarianteratomainanfvbnfemalemousecasereportandliteraturereview AT ruimgildacosta aspontaneousovarianteratomainanfvbnfemalemousecasereportandliteraturereview AT elisabetenascimentogoncalves aspontaneousovarianteratomainanfvbnfemalemousecasereportandliteraturereview AT anamargaridacalado aspontaneousovarianteratomainanfvbnfemalemousecasereportandliteraturereview AT catarinajotabaptista aspontaneousovarianteratomainanfvbnfemalemousecasereportandliteraturereview AT adelinagama aspontaneousovarianteratomainanfvbnfemalemousecasereportandliteraturereview AT fernandaseixas aspontaneousovarianteratomainanfvbnfemalemousecasereportandliteraturereview AT paulaalexandramartinsdeoliveira spontaneousovarianteratomainanfvbnfemalemousecasereportandliteraturereview AT anaifaustinorocha spontaneousovarianteratomainanfvbnfemalemousecasereportandliteraturereview AT ruimgildacosta spontaneousovarianteratomainanfvbnfemalemousecasereportandliteraturereview AT elisabetenascimentogoncalves spontaneousovarianteratomainanfvbnfemalemousecasereportandliteraturereview AT anamargaridacalado spontaneousovarianteratomainanfvbnfemalemousecasereportandliteraturereview AT catarinajotabaptista spontaneousovarianteratomainanfvbnfemalemousecasereportandliteraturereview AT adelinagama spontaneousovarianteratomainanfvbnfemalemousecasereportandliteraturereview AT fernandaseixas spontaneousovarianteratomainanfvbnfemalemousecasereportandliteraturereview |