A role for artificial intelligence in molecular imaging of infection and inflammation

Abstract The detection of occult infections and low-grade inflammation in clinical practice remains challenging and much depending on readers’ expertise. Although molecular imaging, like [18F]FDG PET or radiolabeled leukocyte scintigraphy, offers quantitative and reproducible whole body data on infl...

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Main Authors: Johannes Schwenck, Manfred Kneilling, Niels P. Riksen, Christian la Fougère, Douwe J. Mulder, Riemer J. H. A. Slart, Erik H. J. G. Aarntzen
Format: Article
Language:English
Published: SpringerOpen 2022-09-01
Series:European Journal of Hybrid Imaging
Online Access:https://doi.org/10.1186/s41824-022-00138-1
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author Johannes Schwenck
Manfred Kneilling
Niels P. Riksen
Christian la Fougère
Douwe J. Mulder
Riemer J. H. A. Slart
Erik H. J. G. Aarntzen
author_facet Johannes Schwenck
Manfred Kneilling
Niels P. Riksen
Christian la Fougère
Douwe J. Mulder
Riemer J. H. A. Slart
Erik H. J. G. Aarntzen
author_sort Johannes Schwenck
collection DOAJ
description Abstract The detection of occult infections and low-grade inflammation in clinical practice remains challenging and much depending on readers’ expertise. Although molecular imaging, like [18F]FDG PET or radiolabeled leukocyte scintigraphy, offers quantitative and reproducible whole body data on inflammatory responses its interpretation is limited to visual analysis. This often leads to delayed diagnosis and treatment, as well as untapped areas of potential application. Artificial intelligence (AI) offers innovative approaches to mine the wealth of imaging data and has led to disruptive breakthroughs in other medical domains already. Here, we discuss how AI-based tools can improve the detection sensitivity of molecular imaging in infection and inflammation but also how AI might push the data analysis beyond current application toward predicting outcome and long-term risk assessment.
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spelling doaj.art-1010a0baffd24cc79a3cd66832c4813c2022-12-22T04:04:59ZengSpringerOpenEuropean Journal of Hybrid Imaging2510-36362022-09-016111610.1186/s41824-022-00138-1A role for artificial intelligence in molecular imaging of infection and inflammationJohannes Schwenck0Manfred Kneilling1Niels P. Riksen2Christian la Fougère3Douwe J. Mulder4Riemer J. H. A. Slart5Erik H. J. G. Aarntzen6Department of Nuclear Medicine and Clinical Molecular Imaging, Eberhard Karls UniversityDepartment of Preclinical Imaging and Radiopharmacy, Werner Siemens Imaging Center, Eberhard Karls UniversityDepartment of Internal Medicine, Radboud University Medical CenterDepartment of Nuclear Medicine and Clinical Molecular Imaging, Eberhard Karls UniversityDepartment of Biomedical Photonic Imaging, Faculty of Science and Technology, University of TwenteDepartment of Nuclear Medicine and Molecular Imaging, University Medical Center GroningenDepartment of Internal Medicine, University of Groningen, University Medical Center GroningenAbstract The detection of occult infections and low-grade inflammation in clinical practice remains challenging and much depending on readers’ expertise. Although molecular imaging, like [18F]FDG PET or radiolabeled leukocyte scintigraphy, offers quantitative and reproducible whole body data on inflammatory responses its interpretation is limited to visual analysis. This often leads to delayed diagnosis and treatment, as well as untapped areas of potential application. Artificial intelligence (AI) offers innovative approaches to mine the wealth of imaging data and has led to disruptive breakthroughs in other medical domains already. Here, we discuss how AI-based tools can improve the detection sensitivity of molecular imaging in infection and inflammation but also how AI might push the data analysis beyond current application toward predicting outcome and long-term risk assessment.https://doi.org/10.1186/s41824-022-00138-1
spellingShingle Johannes Schwenck
Manfred Kneilling
Niels P. Riksen
Christian la Fougère
Douwe J. Mulder
Riemer J. H. A. Slart
Erik H. J. G. Aarntzen
A role for artificial intelligence in molecular imaging of infection and inflammation
European Journal of Hybrid Imaging
title A role for artificial intelligence in molecular imaging of infection and inflammation
title_full A role for artificial intelligence in molecular imaging of infection and inflammation
title_fullStr A role for artificial intelligence in molecular imaging of infection and inflammation
title_full_unstemmed A role for artificial intelligence in molecular imaging of infection and inflammation
title_short A role for artificial intelligence in molecular imaging of infection and inflammation
title_sort role for artificial intelligence in molecular imaging of infection and inflammation
url https://doi.org/10.1186/s41824-022-00138-1
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