Recent progress in cancer therapy based on the combination of ferroptosis with photodynamic therapy
Current anticancer treatments have many limitations to achieving high efficacy. Hence, novel strategies that broaden therapeutic prospects must urgently be developed. Ferroptosis is an iron-dependent form of non-apoptotic programmed cell death that is induced by cellular antioxidative system inhibit...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Compuscript Ltd
2022-10-01
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| Series: | Acta Materia Medica |
| Subjects: | |
| Online Access: | https://www.scienceopen.com/hosted-document?doi=10.15212/AMM-2022-0025 |
| _version_ | 1797673832448786432 |
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| author | Zeping Gao Shunzhe Zheng Ken-ichiro Kamei Chutong Tian |
| author_facet | Zeping Gao Shunzhe Zheng Ken-ichiro Kamei Chutong Tian |
| author_sort | Zeping Gao |
| collection | DOAJ |
| description | Current anticancer treatments have many limitations to achieving high efficacy. Hence, novel strategies that broaden therapeutic prospects must urgently be developed. Ferroptosis is an iron-dependent form of non-apoptotic programmed cell death that is induced by cellular antioxidative system inhibition. Photodynamic therapy (PDT) uses photosensitizers to generate reactive oxygen species and aggravate oxidative stress in tumor cells. Combining ferroptosis with PDT cooperatively regulates intracellular redox homeostasis, thus increasing cancer cell susceptibility to oxidative stress and yielding synergistic anticancer effects. In this review, various strategies for combining ferroptosis with PDT are comprehensively summarized and discussed, including mono-PDT and PDT-induced ferroptosis, combining PDT with small-molecule ferroptosis inducers, and combining PDT with metal-ion-induced ferroptosis. Additionally, the possibility of combining ferroptosis and PDT with other anti-tumor therapies is discussed. Finally, the prospects and challenges of combining ferroptosis with PDT in clinical cancer treatment are addressed. With increased understanding of the superiority of combination PDT with ferroptosis for cancer treatment, we hope that drug delivery systems based on this strategy will be further developed to increase anticancer efficiency and achieve successful clinical translation. |
| first_indexed | 2024-03-11T21:51:06Z |
| format | Article |
| id | doaj.art-1011838ca1a444a38e774994c39a82d7 |
| institution | Directory Open Access Journal |
| issn | 2737-7946 |
| language | English |
| last_indexed | 2024-03-11T21:51:06Z |
| publishDate | 2022-10-01 |
| publisher | Compuscript Ltd |
| record_format | Article |
| series | Acta Materia Medica |
| spelling | doaj.art-1011838ca1a444a38e774994c39a82d72023-09-26T08:59:48ZengCompuscript LtdActa Materia Medica2737-79462022-10-011441142610.15212/AMM-2022-0025Recent progress in cancer therapy based on the combination of ferroptosis with photodynamic therapyZeping Gao0Shunzhe Zheng1Ken-ichiro Kamei2Chutong Tian3Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, ChinaWuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, ChinaWuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, ChinaWuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, ChinaCurrent anticancer treatments have many limitations to achieving high efficacy. Hence, novel strategies that broaden therapeutic prospects must urgently be developed. Ferroptosis is an iron-dependent form of non-apoptotic programmed cell death that is induced by cellular antioxidative system inhibition. Photodynamic therapy (PDT) uses photosensitizers to generate reactive oxygen species and aggravate oxidative stress in tumor cells. Combining ferroptosis with PDT cooperatively regulates intracellular redox homeostasis, thus increasing cancer cell susceptibility to oxidative stress and yielding synergistic anticancer effects. In this review, various strategies for combining ferroptosis with PDT are comprehensively summarized and discussed, including mono-PDT and PDT-induced ferroptosis, combining PDT with small-molecule ferroptosis inducers, and combining PDT with metal-ion-induced ferroptosis. Additionally, the possibility of combining ferroptosis and PDT with other anti-tumor therapies is discussed. Finally, the prospects and challenges of combining ferroptosis with PDT in clinical cancer treatment are addressed. With increased understanding of the superiority of combination PDT with ferroptosis for cancer treatment, we hope that drug delivery systems based on this strategy will be further developed to increase anticancer efficiency and achieve successful clinical translation.https://www.scienceopen.com/hosted-document?doi=10.15212/AMM-2022-0025antitumorferroptosisphotodynamic therapycombination therapyintracellular redox homeostasis |
| spellingShingle | Zeping Gao Shunzhe Zheng Ken-ichiro Kamei Chutong Tian Recent progress in cancer therapy based on the combination of ferroptosis with photodynamic therapy Acta Materia Medica antitumor ferroptosis photodynamic therapy combination therapy intracellular redox homeostasis |
| title | Recent progress in cancer therapy based on the combination of ferroptosis with photodynamic therapy |
| title_full | Recent progress in cancer therapy based on the combination of ferroptosis with photodynamic therapy |
| title_fullStr | Recent progress in cancer therapy based on the combination of ferroptosis with photodynamic therapy |
| title_full_unstemmed | Recent progress in cancer therapy based on the combination of ferroptosis with photodynamic therapy |
| title_short | Recent progress in cancer therapy based on the combination of ferroptosis with photodynamic therapy |
| title_sort | recent progress in cancer therapy based on the combination of ferroptosis with photodynamic therapy |
| topic | antitumor ferroptosis photodynamic therapy combination therapy intracellular redox homeostasis |
| url | https://www.scienceopen.com/hosted-document?doi=10.15212/AMM-2022-0025 |
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