The Relationship between Cytokines and Toxoplasma Infection in Heart Disease Patients
Toxoplasmosis is the general term for infection and disease in man and animal caused by a parasite called Toxoplasma gondii, this disease is prevalent among different categories of people, Heart disease are one of them. Because of the dormancy status of T. gondii, there is ambiguity and variation in...
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| Format: | Article |
| Language: | English |
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University of Thi-Qar
2019-04-01
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| Series: | مجلة علوم ذي قار |
| Subjects: | |
| Online Access: | http://jsci.utq.edu.iq/index.php/main/article/view/12 |
| _version_ | 1797404157610557440 |
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| author | Bassad A. Al-Aboody Haider S. Abdulhussein Ahmed H. Mohammed |
| author_facet | Bassad A. Al-Aboody Haider S. Abdulhussein Ahmed H. Mohammed |
| author_sort | Bassad A. Al-Aboody |
| collection | DOAJ |
| description | Toxoplasmosis is the general term for infection and disease in man and animal caused by a parasite called Toxoplasma gondii, this disease is prevalent among different categories of people, Heart disease are one of them. Because of the dormancy status of T. gondii, there is ambiguity and variation in the immunity of patients. This study aimed to investigate the immune status of heart disease patients infected with toxoplasmosis. Two hundred and fifty samples of both heart disease patients and controls had been tested by ELISA technique to detect anti-Toxoplasma Abs (IgG and IgM). The positive samples with toxoplasmosis were tested to detect the level of interleukins (IL-10, IL-12 and IL-17). The result of this study revealed the prevalence of toxoplasmosis among heart disease patient in about (43.33% IgG and 0.66% IgM). The results of interleukins appeared high level of IL-12 (82.85 pg./ml) in heart disease patients infected with toxoplasmosis when compared with control (60.97 pg./ml) with significant difference between them at p≤0.05, while there was no significant difference in IL-10 between patients and controls. The results also showed decreased level of IL-17 in patients with heart disease. The increased level of IL-12 in patient with heart disease infected with toxoplasmosis indicate to the activity of cell mediated immunity in those patients and may be lead to provoke an inflammatory status in the heart valves and muscle then worse heart disease to be sever and need complicated treatments |
| first_indexed | 2024-03-09T02:50:52Z |
| format | Article |
| id | doaj.art-1011c895e7a142eda6de53d524402af7 |
| institution | Directory Open Access Journal |
| issn | 1991-8690 2709-0256 |
| language | English |
| last_indexed | 2024-03-09T02:50:52Z |
| publishDate | 2019-04-01 |
| publisher | University of Thi-Qar |
| record_format | Article |
| series | مجلة علوم ذي قار |
| spelling | doaj.art-1011c895e7a142eda6de53d524402af72023-12-05T09:58:33ZengUniversity of Thi-Qarمجلة علوم ذي قار1991-86902709-02562019-04-0162The Relationship between Cytokines and Toxoplasma Infection in Heart Disease Patients Bassad A. Al-Aboody0Haider S. Abdulhussein1Ahmed H. Mohammed2Department of Biology / College of Science / Thi - Qar UniversityBiology Department / College Science / Thi Qar universityDepartment of Pathological Analysis / College of Science / Thi - Qar UniversityToxoplasmosis is the general term for infection and disease in man and animal caused by a parasite called Toxoplasma gondii, this disease is prevalent among different categories of people, Heart disease are one of them. Because of the dormancy status of T. gondii, there is ambiguity and variation in the immunity of patients. This study aimed to investigate the immune status of heart disease patients infected with toxoplasmosis. Two hundred and fifty samples of both heart disease patients and controls had been tested by ELISA technique to detect anti-Toxoplasma Abs (IgG and IgM). The positive samples with toxoplasmosis were tested to detect the level of interleukins (IL-10, IL-12 and IL-17). The result of this study revealed the prevalence of toxoplasmosis among heart disease patient in about (43.33% IgG and 0.66% IgM). The results of interleukins appeared high level of IL-12 (82.85 pg./ml) in heart disease patients infected with toxoplasmosis when compared with control (60.97 pg./ml) with significant difference between them at p≤0.05, while there was no significant difference in IL-10 between patients and controls. The results also showed decreased level of IL-17 in patients with heart disease. The increased level of IL-12 in patient with heart disease infected with toxoplasmosis indicate to the activity of cell mediated immunity in those patients and may be lead to provoke an inflammatory status in the heart valves and muscle then worse heart disease to be sever and need complicated treatmentshttp://jsci.utq.edu.iq/index.php/main/article/view/12ToxoplasmosisnterleukinHeart disease |
| spellingShingle | Bassad A. Al-Aboody Haider S. Abdulhussein Ahmed H. Mohammed The Relationship between Cytokines and Toxoplasma Infection in Heart Disease Patients مجلة علوم ذي قار Toxoplasmosis nterleukin Heart disease |
| title | The Relationship between Cytokines and Toxoplasma Infection in Heart Disease Patients |
| title_full | The Relationship between Cytokines and Toxoplasma Infection in Heart Disease Patients |
| title_fullStr | The Relationship between Cytokines and Toxoplasma Infection in Heart Disease Patients |
| title_full_unstemmed | The Relationship between Cytokines and Toxoplasma Infection in Heart Disease Patients |
| title_short | The Relationship between Cytokines and Toxoplasma Infection in Heart Disease Patients |
| title_sort | relationship between cytokines and toxoplasma infection in heart disease patients |
| topic | Toxoplasmosis nterleukin Heart disease |
| url | http://jsci.utq.edu.iq/index.php/main/article/view/12 |
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