Expression and activation of nuclear hormone receptors result in neuronal differentiation and favorable prognosis in neuroblastoma

Expression and activation of nuclear hormone receptors result in neuronal differentiation and favorable prognosis in neuroblastoma

Abstract Background Neuroblastoma (NB), a childhood tumor derived from the sympathetic nervous system, presents with heterogeneous clinical behavior. While some tumors regress spontaneously without medical intervention, others are resistant to therapy, associated with an aggressive phenotype. MYCN-a...

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Bibliographic Details
Main Authors: Lourdes Sainero-Alcolado, Muhammad Mushtaq, Judit Liaño-Pons, Aida Rodriguez-Garcia, Ye Yuan, Tong Liu, María Victoria Ruiz-Pérez, Susanne Schlisio, Oscar Bedoya-Reina, Marie Arsenian-Henriksson
Format: Article
Language:English
Published: BMC 2022-07-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Neuroblastoma
Nuclear hormone receptors
Neuronal differentiation
Metabolic reprogramming
Glucocorticoid receptor
Estrogen receptor α
Online Access:https://doi.org/10.1186/s13046-022-02399-x

Internet

https://doi.org/10.1186/s13046-022-02399-x

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