Dynamic neural representations of memory and space during human ambulatory navigation
Abstract Our ability to recall memories of personal experiences is an essential part of daily life. These episodic memories often involve movement through space and thus require continuous encoding of one’s position relative to the surrounding environment. The medial temporal lobe (MTL) is thought t...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-10-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-023-42231-4 |
| _version_ | 1797558355257982976 |
|---|---|
| author | Sabrina L. L. Maoz Matthias Stangl Uros Topalovic Daniel Batista Sonja Hiller Zahra M. Aghajan Barbara Knowlton John Stern Jean-Philippe Langevin Itzhak Fried Dawn Eliashiv Nanthia Suthana |
| author_facet | Sabrina L. L. Maoz Matthias Stangl Uros Topalovic Daniel Batista Sonja Hiller Zahra M. Aghajan Barbara Knowlton John Stern Jean-Philippe Langevin Itzhak Fried Dawn Eliashiv Nanthia Suthana |
| author_sort | Sabrina L. L. Maoz |
| collection | DOAJ |
| description | Abstract Our ability to recall memories of personal experiences is an essential part of daily life. These episodic memories often involve movement through space and thus require continuous encoding of one’s position relative to the surrounding environment. The medial temporal lobe (MTL) is thought to be critically involved, based on studies in freely moving rodents and stationary humans. However, it remains unclear if and how the MTL represents both space and memory especially during physical navigation, given challenges associated with deep brain recordings in humans during movement. We recorded intracranial electroencephalographic (iEEG) activity while participants completed an ambulatory spatial memory task within an immersive virtual reality environment. MTL theta activity was modulated by successful memory retrieval or spatial positions within the environment, depending on dynamically changing behavioral goals. Altogether, these results demonstrate how human MTL oscillations can represent both memory and space in a temporally flexible manner during freely moving navigation. |
| first_indexed | 2024-03-10T17:29:03Z |
| format | Article |
| id | doaj.art-101386c2d0f14a94af2723f129b8bff4 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-03-10T17:29:03Z |
| publishDate | 2023-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-101386c2d0f14a94af2723f129b8bff42023-11-20T10:03:51ZengNature PortfolioNature Communications2041-17232023-10-0114111210.1038/s41467-023-42231-4Dynamic neural representations of memory and space during human ambulatory navigationSabrina L. L. Maoz0Matthias Stangl1Uros Topalovic2Daniel Batista3Sonja Hiller4Zahra M. Aghajan5Barbara Knowlton6John Stern7Jean-Philippe Langevin8Itzhak Fried9Dawn Eliashiv10Nanthia Suthana11Department of Bioengineering, University of California, Los AngelesDepartment of Psychiatry and Biobehavioral Sciences, Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los AngelesDepartment of Psychiatry and Biobehavioral Sciences, Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los AngelesDepartment of Psychiatry and Biobehavioral Sciences, Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los AngelesDepartment of Psychiatry and Biobehavioral Sciences, Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los AngelesDepartment of Psychiatry and Biobehavioral Sciences, Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los AngelesDepartment of Psychology, University of California, Los AngelesDepartment of Neurology, David Geffen School of Medicine, University of California, Los AngelesNeurosurgery Service, Department of Veterans Affairs Greater Los Angeles Healthcare SystemDepartment of Psychiatry and Biobehavioral Sciences, Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los AngelesDepartment of Neurology, David Geffen School of Medicine, University of California, Los AngelesDepartment of Bioengineering, University of California, Los AngelesAbstract Our ability to recall memories of personal experiences is an essential part of daily life. These episodic memories often involve movement through space and thus require continuous encoding of one’s position relative to the surrounding environment. The medial temporal lobe (MTL) is thought to be critically involved, based on studies in freely moving rodents and stationary humans. However, it remains unclear if and how the MTL represents both space and memory especially during physical navigation, given challenges associated with deep brain recordings in humans during movement. We recorded intracranial electroencephalographic (iEEG) activity while participants completed an ambulatory spatial memory task within an immersive virtual reality environment. MTL theta activity was modulated by successful memory retrieval or spatial positions within the environment, depending on dynamically changing behavioral goals. Altogether, these results demonstrate how human MTL oscillations can represent both memory and space in a temporally flexible manner during freely moving navigation.https://doi.org/10.1038/s41467-023-42231-4 |
| spellingShingle | Sabrina L. L. Maoz Matthias Stangl Uros Topalovic Daniel Batista Sonja Hiller Zahra M. Aghajan Barbara Knowlton John Stern Jean-Philippe Langevin Itzhak Fried Dawn Eliashiv Nanthia Suthana Dynamic neural representations of memory and space during human ambulatory navigation Nature Communications |
| title | Dynamic neural representations of memory and space during human ambulatory navigation |
| title_full | Dynamic neural representations of memory and space during human ambulatory navigation |
| title_fullStr | Dynamic neural representations of memory and space during human ambulatory navigation |
| title_full_unstemmed | Dynamic neural representations of memory and space during human ambulatory navigation |
| title_short | Dynamic neural representations of memory and space during human ambulatory navigation |
| title_sort | dynamic neural representations of memory and space during human ambulatory navigation |
| url | https://doi.org/10.1038/s41467-023-42231-4 |
| work_keys_str_mv | AT sabrinallmaoz dynamicneuralrepresentationsofmemoryandspaceduringhumanambulatorynavigation AT matthiasstangl dynamicneuralrepresentationsofmemoryandspaceduringhumanambulatorynavigation AT urostopalovic dynamicneuralrepresentationsofmemoryandspaceduringhumanambulatorynavigation AT danielbatista dynamicneuralrepresentationsofmemoryandspaceduringhumanambulatorynavigation AT sonjahiller dynamicneuralrepresentationsofmemoryandspaceduringhumanambulatorynavigation AT zahramaghajan dynamicneuralrepresentationsofmemoryandspaceduringhumanambulatorynavigation AT barbaraknowlton dynamicneuralrepresentationsofmemoryandspaceduringhumanambulatorynavigation AT johnstern dynamicneuralrepresentationsofmemoryandspaceduringhumanambulatorynavigation AT jeanphilippelangevin dynamicneuralrepresentationsofmemoryandspaceduringhumanambulatorynavigation AT itzhakfried dynamicneuralrepresentationsofmemoryandspaceduringhumanambulatorynavigation AT dawneliashiv dynamicneuralrepresentationsofmemoryandspaceduringhumanambulatorynavigation AT nanthiasuthana dynamicneuralrepresentationsofmemoryandspaceduringhumanambulatorynavigation |