ARV-771 Acts as an Inducer of Cell Cycle Arrest and Apoptosis to Suppress Hepatocellular Carcinoma Progression

ARV-771 Acts as an Inducer of Cell Cycle Arrest and Apoptosis to Suppress Hepatocellular Carcinoma Progression

Hepatocellular carcinoma (HCC) is the most commonly diagnosed liver cancer with limited treatment options and extremely poor prognosis worldwide. Recently, the proteolysis targeting chimeras (PROTACs), which aim to induce proteasome-mediated degradation of interesting proteins via recruiting E3 liga...

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Bibliographic Details
Main Authors: Yuanfei Deng, Cuifu Yu, Lushi Chen, Xin Zhang, Qiucheng Lei, Qing Liu, Gengxi Cai, Fang Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Pharmacology
Subjects:
hepatocellular carcinoma
PROTACs
ARV-771
deubiquitinases
MAPKs
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.858901/full

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