CYCLIN-DEPENDENT KINASE INHIBITOR, PALBOCICLIB – A NEW DRUG FOR THE TREATMENT OF METASTATIC BREAST CANCER
The sequential use of several lines of endocrine therapy is considered the standard for the treatment of metastatic breast cancer, expressing estrogen or progesterone receptors. PALOMA-1, -2 and -3 studies showed that the combination of the inhibitor of CDK4/6, palbociclib, with endocrine therapy si...
| Main Authors: | , |
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| Format: | Article |
| Language: | Russian |
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ABV-press
2017-12-01
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| Series: | Опухоли женской репродуктивной системы |
| Subjects: | |
| Online Access: | https://ojrs.abvpress.ru/ojrs/article/view/561 |
| _version_ | 1826557254936035328 |
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| author | E. N. Imyanitov T. Yu. Semiglazova |
| author_facet | E. N. Imyanitov T. Yu. Semiglazova |
| author_sort | E. N. Imyanitov |
| collection | DOAJ |
| description | The sequential use of several lines of endocrine therapy is considered the standard for the treatment of metastatic breast cancer, expressing estrogen or progesterone receptors. PALOMA-1, -2 and -3 studies showed that the combination of the inhibitor of CDK4/6, palbociclib, with endocrine therapy significantly increases the time to progression compared to the use of monotherapy with antagonists of the estrogen signaling cascade. |
| first_indexed | 2024-04-10T01:56:06Z |
| format | Article |
| id | doaj.art-10144e1462404eff8595e3c3949344de |
| institution | Directory Open Access Journal |
| issn | 1994-4098 1999-8627 |
| language | Russian |
| last_indexed | 2025-03-14T08:25:41Z |
| publishDate | 2017-12-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Опухоли женской репродуктивной системы |
| spelling | doaj.art-10144e1462404eff8595e3c3949344de2025-03-02T13:05:34ZrusABV-pressОпухоли женской репродуктивной системы1994-40981999-86272017-12-01134344310.17650/1994-4098-2017-13-4-34-43553CYCLIN-DEPENDENT KINASE INHIBITOR, PALBOCICLIB – A NEW DRUG FOR THE TREATMENT OF METASTATIC BREAST CANCERE. N. Imyanitov0T. Yu. Semiglazova1N.N. Petrov National Medical Research Center of Onclology, Ministry of Health of Russia; Saint Petersburg State Pediatric Medical University, Ministry of Health of RussiaN.N. Petrov National Medical Research Center of Onclology, Ministry of Health of Russia; I.I. Mechnikov North-Western State Medical University Ministry of Health of RussiaThe sequential use of several lines of endocrine therapy is considered the standard for the treatment of metastatic breast cancer, expressing estrogen or progesterone receptors. PALOMA-1, -2 and -3 studies showed that the combination of the inhibitor of CDK4/6, palbociclib, with endocrine therapy significantly increases the time to progression compared to the use of monotherapy with antagonists of the estrogen signaling cascade.https://ojrs.abvpress.ru/ojrs/article/view/561metastatic er-positive breast cancerfactors of poor prognosisresistancehormonal therapypalbociclib |
| spellingShingle | E. N. Imyanitov T. Yu. Semiglazova CYCLIN-DEPENDENT KINASE INHIBITOR, PALBOCICLIB – A NEW DRUG FOR THE TREATMENT OF METASTATIC BREAST CANCER Опухоли женской репродуктивной системы metastatic er-positive breast cancer factors of poor prognosis resistance hormonal therapy palbociclib |
| title | CYCLIN-DEPENDENT KINASE INHIBITOR, PALBOCICLIB – A NEW DRUG FOR THE TREATMENT OF METASTATIC BREAST CANCER |
| title_full | CYCLIN-DEPENDENT KINASE INHIBITOR, PALBOCICLIB – A NEW DRUG FOR THE TREATMENT OF METASTATIC BREAST CANCER |
| title_fullStr | CYCLIN-DEPENDENT KINASE INHIBITOR, PALBOCICLIB – A NEW DRUG FOR THE TREATMENT OF METASTATIC BREAST CANCER |
| title_full_unstemmed | CYCLIN-DEPENDENT KINASE INHIBITOR, PALBOCICLIB – A NEW DRUG FOR THE TREATMENT OF METASTATIC BREAST CANCER |
| title_short | CYCLIN-DEPENDENT KINASE INHIBITOR, PALBOCICLIB – A NEW DRUG FOR THE TREATMENT OF METASTATIC BREAST CANCER |
| title_sort | cyclin dependent kinase inhibitor palbociclib a new drug for the treatment of metastatic breast cancer |
| topic | metastatic er-positive breast cancer factors of poor prognosis resistance hormonal therapy palbociclib |
| url | https://ojrs.abvpress.ru/ojrs/article/view/561 |
| work_keys_str_mv | AT enimyanitov cyclindependentkinaseinhibitorpalbociclibanewdrugforthetreatmentofmetastaticbreastcancer AT tyusemiglazova cyclindependentkinaseinhibitorpalbociclibanewdrugforthetreatmentofmetastaticbreastcancer |