Doença de Whipple--um desafio diagnóstico.
Whipple's Disease is a rare multisystemic disease caused by Gram-positive bacillus, Tropheryma whippelii, family of Actinobacterias and group of Actinomycetes. Because the disease is rare and has different forms of presentation the diagnosis comes frequently late. The authors present the case o...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Ordem dos Médicos
2004-12-01
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| Series: | Acta Médica Portuguesa |
| Online Access: | https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/1117 |
| _version_ | 1798021048134795264 |
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| author | Ana C Carneiro Palmira Lima Isabel P Barbosa F Carneiro Chaves |
| author_facet | Ana C Carneiro Palmira Lima Isabel P Barbosa F Carneiro Chaves |
| author_sort | Ana C Carneiro |
| collection | DOAJ |
| description | Whipple's Disease is a rare multisystemic disease caused by Gram-positive bacillus, Tropheryma whippelii, family of Actinobacterias and group of Actinomycetes. Because the disease is rare and has different forms of presentation the diagnosis comes frequently late. The authors present the case of a white man, 50 years old, admitted with a clinical picture characterized by weight loss, abdominal pain, ascites, diarrhea. He suffered of arthralgias for four years. The diagnosis was made by biopsy of mesenteric adenopathies and liver, during the laparotomy. The biopsy specimens showed numerous aggregates of foamy macrophages containing granular periodic acid-shiff (PAS)--positive material, diastase resistant. Afterwards, the bacillus was identified by electronic microscopy. The patient was treated with trimethoprim-sulfamethoxazole. Symptoms disappeared and biological values returned to normal. The authors present the case and discuss auxiliary exams, differential diagnosis, follow-up, treatment and review the main characteristics of the disease. |
| first_indexed | 2024-04-11T17:07:41Z |
| format | Article |
| id | doaj.art-101594a829114883b0928c9b505c3987 |
| institution | Directory Open Access Journal |
| issn | 0870-399X 1646-0758 |
| language | English |
| last_indexed | 2024-04-11T17:07:41Z |
| publishDate | 2004-12-01 |
| publisher | Ordem dos Médicos |
| record_format | Article |
| series | Acta Médica Portuguesa |
| spelling | doaj.art-101594a829114883b0928c9b505c39872022-12-22T04:12:59ZengOrdem dos MédicosActa Médica Portuguesa0870-399X1646-07582004-12-0117610.20344/amp.1117Doença de Whipple--um desafio diagnóstico.Ana C Carneiro0Palmira LimaIsabel P BarbosaF Carneiro ChavesServiço de Medicina A, Hospital S. João, Porto.Whipple's Disease is a rare multisystemic disease caused by Gram-positive bacillus, Tropheryma whippelii, family of Actinobacterias and group of Actinomycetes. Because the disease is rare and has different forms of presentation the diagnosis comes frequently late. The authors present the case of a white man, 50 years old, admitted with a clinical picture characterized by weight loss, abdominal pain, ascites, diarrhea. He suffered of arthralgias for four years. The diagnosis was made by biopsy of mesenteric adenopathies and liver, during the laparotomy. The biopsy specimens showed numerous aggregates of foamy macrophages containing granular periodic acid-shiff (PAS)--positive material, diastase resistant. Afterwards, the bacillus was identified by electronic microscopy. The patient was treated with trimethoprim-sulfamethoxazole. Symptoms disappeared and biological values returned to normal. The authors present the case and discuss auxiliary exams, differential diagnosis, follow-up, treatment and review the main characteristics of the disease.https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/1117 |
| spellingShingle | Ana C Carneiro Palmira Lima Isabel P Barbosa F Carneiro Chaves Doença de Whipple--um desafio diagnóstico. Acta Médica Portuguesa |
| title | Doença de Whipple--um desafio diagnóstico. |
| title_full | Doença de Whipple--um desafio diagnóstico. |
| title_fullStr | Doença de Whipple--um desafio diagnóstico. |
| title_full_unstemmed | Doença de Whipple--um desafio diagnóstico. |
| title_short | Doença de Whipple--um desafio diagnóstico. |
| title_sort | doenca de whipple um desafio diagnostico |
| url | https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/1117 |
| work_keys_str_mv | AT anaccarneiro doencadewhippleumdesafiodiagnostico AT palmiralima doencadewhippleumdesafiodiagnostico AT isabelpbarbosa doencadewhippleumdesafiodiagnostico AT fcarneirochaves doencadewhippleumdesafiodiagnostico |